A genetic condition, termed as cystic fibrosis (CF) affecting numerous organs, including the lungs, pancreas, colon, liver, and reproductive system, is completely dormant and intrinsic. Better treatment and control of CF are facilitated by early diagnosis. With the advent of technological and healthcare developments, there have been tremendous advancements in detecting CF rapidly and administering therapeutics. Accordingly, these short communication overviews developments related to early diagnosis of CF with dermal stickers. Apart from this, the future perspectives are also appraised.