Facile N‐Formylation of Amines on Magnetic Fe₃O₄−CuO Nanocomposites

Abstract

A facile, eco-friendly, efficient, and recyclable heterogeneous catalyst is synthesized by immobilizing copper impregnated on mesoporous magnetic nanoparticles. The surface chemistry analysis of Fe 3 O 4 À CuO nanocomposites (NCs) by XRD and XPS demonstrates the synergistic effect between Fe 3 O 4 and CuO nanoparticles, providing mass-transfer channels for the catalytic reaction. TEM images clearly indicate the impregnation of CuO onto mesoporous Fe 3 O 4 . This hydrothermally synthesized ecofriendly and highly efficient Fe 3 O 4 À CuO NCs are applied as a magnetically retrievable heterogeneous catalyst for the Nformylation of wide range of aliphatic, aromatic, polyaromatic and heteroaromatic amines using formic acid as a formylating agent at room temperature. The catalytic activity of the NCs for N-formylation is attributable to the synergistic effect between Fe 3 O 4 and CuO nanoparticles. The N-formylated product is further employed for the synthesis of biologically active quinolone moieties.

Metal‐Free N‐Doped Carbon Catalyst Derived from Chitosan for Aqueous Formic Acid‐Mediated Selective Reductive Formylation of Quinoline and Nitroarenes

“…For the reductive formylation of N-arenes and nitroaromatics, the reducing and formylating agent choice is crucial as the process is not facile due to the delocalization of π-bonds. Various noble and transition metal-based catalysts such as Pd, Pt, Au, and Co have been employed along with HCOOH as an H 2 /CO source to carry out reductive Nformylation, [28][29][30][31] but the development of a metal-free catalyst remains an exciting but challenging task.…”

Hexamethyldisilazane‐Mediated Synthesis of N‐Formamides, Benzimidazoles and Quinazolinones Using N,N‐Dimethylformamide as a C1 Source

“…The authors have cited additional references within the Supporting Information. [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]…”

Recent Advancements in Strategies for the Synthesis of Imidazoles, Thiazoles, Oxazoles, and Benzimidazoles

“…[163] In 2021, Mishra and his colleagues coincidentally discussed the concept of "click chemistry" and the utilization of coppercatalyzed organic transformations (Scheme 139). [164] They emphasized the benefits of copper-based catalysts, such as their affordability, high yield, lack of significant by-products, and environmentally friendly qualities. To achieve this, they immobilized copper on mesoporous magnetic nanoparticles, creating a highly efficient and recyclable catalyst called CuO, a transition metal oxide.…”