Facile in situ PEGylation of polyamide thin film composite membranes for improving fouling resistance

Gol, Ravindra M.; Jewrajka, Suresh K.

doi:10.1016/j.memsci.2013.12.058

Cited by 54 publications

(35 citation statements)

References 31 publications

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“…Elemental analysis was carried out according to a reported method. 19) PLO and mPEG-SH were dissolved in distilled water and mixed completely at each ratio, and then these mixtures were freeze-dried. The dried samples were measured with a micro element analyzer (MT-6 CHN Corder, Yanaco, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer

Kamiya

Yamaki

Uchida

et al. 2017

Biological & Pharmaceutical Bulletin

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Polycationic compounds, such as poly-L-arginine and poly-L-ornithine (PLO), enhance the nasal absorption of hydrophilic macromolecular drugs. However, the bio availability corresponding to the dose of these enhancers has not been obtained in an open system study, where an administered solution is transferred to the pharynx because they do not exhibit mucoadhesion/retention in the nasal cavity. In this study, we prepared PEGylated-poly-L-ornithine (PEG-PLO) and investigated the effects of PEGylation on in vitro adhesion/retention properties, permeation enhancement efficiency, and cytotoxicity. PEG-PLO bearing 3-4 polyethylene glycol (PEG) chains per PLO molecule was more retentive than unmodified PLO on an inclined plate. The permeability of a model drug, FD-4, across Caco-2 cell sheets was enhanced by PEG-PLO as well as by PLO. PLO showed cytotoxicity at high concentrations, whereas PEG-PLO did not decrease cell viability, even above the concentration giving a sufficient enhancement effect. These findings suggest that PEGylation of polycationic absorption enhancers improves their adhesion/retention and decreases their cytotoxicity, which may lead to enhancers with greater utility.Key words poly-L-ornithine (PLO); polyethylene glycol (PEG); permeation enhancer Bioactive peptides, such as insulin, teriparatide, liraglutide, and somatropin, have been used widely as therapeutic drugs because of their intrinsic and effective activities, however, they have poor permeability across the epithelium because they are hydrophilic macromolecules. Orally administered peptides are often inactivated in the gastrointestinal tract, and thus peptides are usually administered as injectable formulations. However, injection can result in poor compliance because it is painful and burdensome. 1) Therefore, alternative routes of administration are required.The nasal mucosa has a large surface area for absorption because of its villus structure. Drugs absorbed across the nasal mucosa avoid the hepatic first pass effect because of the abundant vasculature under the nasal mucosa.2) The intranasal route is effective for absorbing high molecular weight drugs 3) and is usually not painful. Therefore, intranasal administration is an important alternative route to injection for peptides and proteins.Polycationic compounds, such as poly-L-arginine (PLA), poly-L-lysine, and poly-L-ornithine (PLO), enhance the transmucosal absorption of hydrophilic macromolecules.4,5) PLA enhances the paracellular permeability of rabbit nasal mucosa and Caco-2 cell sheets reversibly.6,7) The absorption of hydrophilic macromolecules across the nasal mucosa in rats is also increased by co-administration with PLA. 8) PLA enhances the permeability by altering the localization of tight junction proteins from the cell-cell junction to the intracellular space without causing cytotoxicity. 9) Therefore, polycationic absorption enhancers are useful in developing efficient transmucosal drug delivery systems.Nevertheless, it is difficult to increase the bioavailability of dr...

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Section: Methodsmentioning

confidence: 99%

Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer

Kamiya

Yamaki

Uchida

et al. 2017

Biological & Pharmaceutical Bulletin

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“…Gol and Jewrajka [21] reported a novel approach for in-situ PEGylation on TFC membranes, which could effectively enhance antifouling capability of membranes. Meanwhile, salt rejection and water flux were almost unaffected.…”

Section: Introductionmentioning

confidence: 99%

Preparation of thin-film composite nanofiltration membranes with improved antifouling property and flux using 2,2′-oxybis-ethylamine

et al. 2015

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“…100 kD) was prepared as described earlier [17,28]. Polyamide active layer on the top of PSf support was prepared by in situ IFP between TMC taken in hexane at room temperature with (i) MPD, (ii) melamine, and (iii) mixture of MPD + melamine taken in water at temperature~60°C separately.…”

Section: Preparation Of Non-pegylated Tfc Membranesmentioning

confidence: 99%

“…10. The detail of the preparation of MPD + MeO-PEG-MPD mixture for PEGylation of TFC membrane was reported earlier by us [28]. PEGylated TFC membranes were prepared using MPD + melamine + MeO-PEG-MPD mixtures as amine source and same procedure was followed as described for the preparation of non-PEGylated TFC membranes.…”

Section: Preparation Of Pegylated Tfc Membranes Containing Triazing Ringmentioning

confidence: 99%

“…Our previous publications reported in situ hydrophilic modification (PEGylation) of TFC membranes for the improvement of antifouling property. The PEGylated membranes exhibited good anti-protein (bovine serum albumin) fouling property during desalination of water [28,29]. It is desirable to prepare TFC membranes with both organic and bio-antifouling properties for smooth RO application.…”

Section: Introductionmentioning

confidence: 99%

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PEGylation and incorporation of triazine ring into thin film composite reverse osmosis membranes for enhancement of anti-organic and anti-biofouling properties

et al. 2015

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Facile in situ PEGylation of polyamide thin film composite membranes for improving fouling resistance

Cited by 54 publications

References 31 publications

Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer

Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer

Preparation of thin-film composite nanofiltration membranes with improved antifouling property and flux using 2,2′-oxybis-ethylamine

PEGylation and incorporation of triazine ring into thin film composite reverse osmosis membranes for enhancement of anti-organic and anti-biofouling properties

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