Facile In Situ Photochemical Synthesis of Silver Nanoaggregates for Surface-Enhanced Raman Scattering Applications

Yin, Zhang; He, Huilin; Wang, Zhenming; Fang, Xiaoguo; Xu, Chunxiang; Luo, Dan; Jiang, Shouzhen; Liu, Yan Jun

doi:10.3390/nano10040685

Cited by 12 publications

(9 citation statements)

References 39 publications

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“…Dispersion of size in plasmonic particles produces a broad plasmonic spectrum that could be useful for performing SERS at different wavelengths (Mao et al, 2020). A similar effect could be also obtained with dendrites (Lu et al, 2020) or particles with a dispersion of forms (Yin et al, 2020).…”

Section: Characterization Of Si-agnps Substratesmentioning

confidence: 76%

Indirect Quantification of Glyphosate by SERS Using an Incubation Process With Hemin as the Reporter Molecule: A Contribution to Signal Amplification Mechanism

et al. 2020

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The indirect determination of the most used herbicide worldwide, glyphosate, was achieved by the SERS technique using hemin chloride as the reporter molecule. An incubation process between hemin and glyphosate solutions was required to obtain a reproducible Raman signal on SERS substrates consisting of silicon decorated with Ag nanoparticles (Si-AgNPs). At 780 nm of excitation wavelength, SERS spectra from hemin solutions do not show extra bands in the presence of glyphosate. However, the hemin bands increase in intensity as a function of glyphosate concentration. This allows the quantification of the herbicide using as marker band the signal associated with the ring breathing mode of pyridine at 745 cm−1. The linear range was from 1 × 10−10 to 1 × 10−5 M and the limit of detection (LOD) was 9.59 × 10−12 M. This methodology was successfully applied to the quantification of the herbicide in honey. From Raman experiments with and without silver nanoparticles, it was possible to state that the hemin is the species responsible for the absorption in the absence or the presence of the herbicide via vinyl groups. Likewise, when the glyphosate concentration increases, a subtle increase occurs in the planar orientation of the vinyl group at position 2 in the porphyrin ring of hemin over the silver surface, favoring the reduction of the molecule. The total Raman signal of the hemin-glyphosate incubated solutions includes a maximized electromagnetic contribution by the use of the appropriate laser excitation, and chemical contributions related to charge transfer between silver and hemin, and from resonance properties of Raman scattering of hemin. Incubation of the reporter molecule with the analyte before the conjugation with the SERS substrate has not been explored before and could be extrapolated to other reporter-analyte systems that depend on a binding equilibrium process.

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Section: Characterization Of Si-agnps Substratesmentioning

confidence: 76%

Indirect Quantification of Glyphosate by SERS Using an Incubation Process With Hemin as the Reporter Molecule: A Contribution to Signal Amplification Mechanism

et al. 2020

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“…Therefore, GO-coated plasmonic SERS substrates could have much higher sensitivity and lower detection limits due to a combination of chemical enhancement of GO and the number of hot spots of plasmonic nanostructures. Various methods have been proposed to form thin GO films on structures, such as dip coating, spin coating, and electric-field-assisted coating [ 67 , 68 , 69 , 70 ]. For electric-field-assisted coating, the Ag oxidation could be accelerated with the exposure to plasma or chemical solution with electric charges.…”

Section: Resultsmentioning

confidence: 99%

“…We can see that with the GO-coating, the Raman signals can be greatly enhanced. The analytical enhancement factor (AEF) [ 70 ] is calculated using the equation below to further quantify the enhanced distribution of the SERS substrate: AEF = (I SERS × C REF )/(I REF × C SERS ) where I SERS and I REF represent the peak intensity of the Raman signal from the GO/Ag/SiO 2 /Au/Si substrate and the Raman signal obtained from the Si substrate, respectively. C SERS and C REF are the concentrations of melamine solutions dropped on the SERS and reference substrates, respectively.…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide-Coated Metal–Insulator–Metal SERS Substrates for Trace Melamine Detection

et al. 2022

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Surface-enhanced Raman spectroscopy (SERS) has long been an ultrasensitive technique for trace molecule detection. However, the development of a sensitive, stable, and reproducible SERS substrate is still a challenge for practical applications. Here, we demonstrate a cost-effective, centimeter-sized, and highly reproducible SERS substrate using the nanosphere lithography technique. It consists of a hexagonally packed Ag metasurface on a SiO2/Au/Si substrate. A seconds-lasting etching process of a self-assembled nanosphere mask manipulates the geometry of the deposited Ag metasurface on the SiO2/Au/Si substrate, which attains the wavelength matching between the optical absorbance of the Ag/SiO2/Au/Si substrate and the excitation laser wavelength as well as the enhancement of Raman signals. By spin-coating a thin layer of graphene oxide on the substrate, a SERS performance with 1.1 × 105 analytical enhancement factor and a limit of detection of 10−9 M for melamine is achieved. Experimental results reveal that our proposed strategy could provide a promising platform for SERS-based rapid trace detection in food safety control and environmental monitoring.

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“…We summarize the most recent work on SERS microfluidic systems into four main categories based on the method to pattern silver nanoparticles on channel surfaces: deposition, photoreduction, − electrochemical reduction, − and chemical reduction. − Most of the microfluidic systems did not give much consideration toward channel geometry. However, it is well known that mixing is an inherited problem in most microchannels due to laminar flows at a low Reynolds number .…”

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confidence: 99%

“…Without a rational design toward microchannel geometry, these SERS microfluidic systems generally lack a good control over the size and uniformity of silver nanoparticles patterned on channel surfaces. For example, silver materials fabricated in photoreduction-based microfluidic platforms usually turn out to be aggregates with random size and morphology, resulting in low resolution and poor reproducibility for Raman measurements. − Meanwhile, insufficient mixing of reagents reduces reaction efficacy, which has to be compensated at the expense of ease of fabrication. − Such cases are usually seen in most of the deposition- or electrochemical reduction-based systems that require either templates or prepatterned copper electrodes. − Another issue with inefficient mixing is the introduction of unfavorable reagent residues or by-products such as the case with most existing patterning techniques based on chemical reduction. − …”

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confidence: 99%

Microfluidic In Situ Patterning of Silver Nanoparticles for Surface-Enhanced Raman Spectroscopic Sensing of Biomolecules

2021

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This work integrates the advantages of microfluidic devices, nanoparticle synthesis, and on-chip sensing of biomolecules. The concept of microreactors brings new opportunities in chemical synthesis, especially for metallic nanoparticles favorable in surface-enhanced Raman spectroscopy (SERS) for high-resolution and low-limit detection of biomolecules. However, still missing is our understanding of reactions at the microscale and how microsystems can be exploited in biosensing applications via precise control of nanomaterial synthesis. We investigate how microfluidic geometry affects nanoparticle patterning for high-resolution SERS-based sensing and propose a spiral-shaped microchannel that can achieve enhanced mixing, rapid reaction at room temperature, and uniform in situ patterning. The roles of channel geometry as the key parameter on patterning have been studied systematically to provide insight into the rational design of continuous microfluidic systems for SERS applications. We also demonstrate potential applications of this integrated system in label-free on-chip detection of 1 pM rhodamine B (enhancement factor, ∼4.3 × 1011) and a 1 nM 41-base single-stranded deoxyribonucleic acid (DNA) sequence (enhancement factor, ∼1.5 × 108). Our ready-to-use multifunctional system provides an alternative strategy for the facile fabrication of SERS-active substrates and promotes system integration, miniaturization, and on-site biological applications.

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Facile In Situ Photochemical Synthesis of Silver Nanoaggregates for Surface-Enhanced Raman Scattering Applications

Cited by 12 publications

References 39 publications

Indirect Quantification of Glyphosate by SERS Using an Incubation Process With Hemin as the Reporter Molecule: A Contribution to Signal Amplification Mechanism

Indirect Quantification of Glyphosate by SERS Using an Incubation Process With Hemin as the Reporter Molecule: A Contribution to Signal Amplification Mechanism

Graphene Oxide-Coated Metal–Insulator–Metal SERS Substrates for Trace Melamine Detection

Microfluidic In Situ Patterning of Silver Nanoparticles for Surface-Enhanced Raman Spectroscopic Sensing of Biomolecules

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