Facile isolation and analysis of sporopollenin exine from bee pollen

Hegedüs, Kristóf; Fehér, Csaba; Jalsovszky, István; Kristóf, Zoltán; Rohonczy, János; Vass, Elemér; Farkas, Attila; Csizmadia, Tamás; Friedbacher, Gernot; Hantz, Péter

doi:10.1038/s41598-021-87619-8

Cited by 14 publications

(3 citation statements)

References 63 publications

(58 reference statements)

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“…Hegedu ¨s et al studied the chemical structure of sporopollenin from sunflower and oilseed rape by solid-state NMR spectroscopy, whose results were similar to that of pine sporopollenin. 42 Through heteronuclear single quantum coherence (HSQC) NMR spectroscopy, Xue et al further revealed that, in addition to aliphatic compounds, sporopollenin from lily also contains phenolic compounds and phenylpropane derivatives, including lignin guaiac G units, paracoumarate (p-CA), paraben (p-BA) and ferulate (FA) (Fig. 2d).…”

Section: Yuetong Wangmentioning

confidence: 99%

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Extraordinary microcarriers derived from spores and pollens

Zhao

Zhang

et al. 2023

Mater. Horiz.

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Section: Yuetong Wangmentioning

confidence: 99%

“…5d). 42 4.1.2 Enzyme extraction. Because the exine of multicellular pollen is thin and easy to break, the enzymatic method based on the digestion of enzymes is well suited.…”

Section: Extracting Sporopollenin Exine Shellsmentioning

confidence: 99%

Extraordinary microcarriers derived from spores and pollens

Zhao

Zhang

et al. 2023

Mater. Horiz.

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“…It is obtained as a result of lactic acid fermentation of pollens by some bacteria and fungi (4)(5)(6). In addition, corbiculate bees add regurgitated fluid with the grains to facilitate pollen adherence to the OPEN ACCESS EDITED BY pollen baskets and pollen grains (8)(9)(10). BP is collected by adult forager bees and transported to the hive.…”

Section: Introductionmentioning

confidence: 99%

Bee pollen as a food and feed supplement and a therapeutic remedy: recent trends in nanotechnology

Anjum,

Ullah,

Gohar

et al. 2024

Front. Nutr.

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Pollen grains are the male reproductive part of the flowering plants. It is collected by forager honey bees and mixed with their salivary secretions, enzymes, and nectar, which form fermented pollen or “bee bread” which is stored in cells of wax honeycombs. Bee pollen (BP) is a valuable apitherapeutic product and is considered a nutritional healthy food appreciated by natural medicine from ancient times. Recently, BP has been considered a beneficial food supplement and a value-added product that contains approximately 250 different bioactive components. It contains numerous beneficial elements such as Mg, Ca, Mn, K, and phenolic compounds. BP possesses strong antioxidant, anti-inflammatory, antimicrobial, antiviral, analgesic, immunostimulant, neuroprotective, anti-cancer, and hepatoprotective properties. It is used for different purposes for the welfare of mankind. Additionally, there is a growing interest in honey bee products harvesting and utilizing for many purposes as a natural remedy and nutritive function. In this review, the impacts of BP on different organisms in different ways by highlighting its apitherapeutic efficacy are described.

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Harnessing Natural Pollen as Sustained‐Release, Mucoadhesive, and Biosafe Drug Microcapsules for Intravesical Instillation in Bladder Cancer Treatment

Hu,

Zhou,

Zou

et al. 2024

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Intravesical instillation is essential for bladder cancer treatment, but current therapy suffers from brief drug retention and insufficient contact bladder contact. Nano‐ and micro‐sized capsules‐based drug delivery systems are expected to solve these problems, which, however, face challenges such as weak mucoadhesion, low biosafety, and processing complexity, limiting their scalable application. In this study, the power of plant pollen‐derived microcapsules, sporopollenin exine capsules (SECs) is harnessed that are produced by sequentially defatting and acidolysis sunflower pollen, to passive load with pirarubicin and achieve biosafe and high‐efficiency intravesical chemotherapy. SECs exhibit no significant toxic effects in vitro or in vivo. Taking advantage of its intrinsic microscale core–shell structure and spiny surface topography, convenient encapsulation is achieved with an efficiency of 45.3±1.43% and sustained release of the simulate drug, and strong adhesion to the bladder mucosa even after multiple urination, which reduces the instillation‐maintenance time to just 20 min. Drugs encapsulated in SECs maintained higher concentrations in the bladder for up to 5 h compared to those without SECs. In a murine orthotopic bladder cancer model, SECs enhance the intravesical chemotherapy effect of pirorubicin (increased by 38%). The study introduces an innovative, naturally occurring drug carrier for advancing future intravesical instillation therapies.

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Facile isolation and analysis of sporopollenin exine from bee pollen

Cited by 14 publications

References 63 publications

Extraordinary microcarriers derived from spores and pollens

Extraordinary microcarriers derived from spores and pollens

Bee pollen as a food and feed supplement and a therapeutic remedy: recent trends in nanotechnology

Harnessing Natural Pollen as Sustained‐Release, Mucoadhesive, and Biosafe Drug Microcapsules for Intravesical Instillation in Bladder Cancer Treatment

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