Facile method for large scale synthesis of magnetic inorganic–organic hybrid anisotropic Janus particles

Liu, Bin; Zhang, Wei; Zhang, Dongwei; Yang, Xinlin

doi:10.1016/j.jcis.2012.06.032

Cited by 22 publications

(10 citation statements)

References 30 publications

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“…The desire for drug delivery systems with tunable properties and multiple functionalities has spawned a new generation of particulate carriers, including Janus particles. 1–7 Current approaches to nanoparticle-based combination therapy include administering a cocktail of single-drug nanoparticles, coencapsulating multiple drugs into a single nanoparticle core, 8,9 conjugating one drug to the particle surface while encapsulating the other inside of the core, 2 and covalently conjugating multiple drugs to the same polymer backbone. 10 While innovative, these strategies fail to provide co-delivery of two drugs with strongly dissimilar aqueous solubility (i.e.…”

Section: Introductionmentioning

confidence: 99%

Dual drug-loaded biodegradable Janus particles for simultaneous co-delivery of hydrophobic and hydrophilic compounds

Winkler

Barai

Tomassone

2019

Exp Biol Med (Maywood)

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Bicompartmental Janus particles have many advantages in drug delivery, including co-delivery of two compounds with varying solubilities, differential release kinetics, and two surfaces available for targeting ligands. We present a novel strategy using the double emulsion method for the coencapsulation and staggered release of a hydrophobic and hydrophilic drug from anisotropic PLGA/PCL Janus particles, as well as a UV detection method to measure the release of two different compounds from Janus particles. Curcumin and quercetin were chosen as the model hydrophobic compounds for drug loading studies, while acetaminophen (APAP) and naproxen were chosen as the model hydrophilic–hydrophobic drug pair for encapsulation methods and drug loading. Also, a similar double emulsion method was also applied for PLGA/Preicrol® Janus particles containing Doxorubicin and Curcumin. Hydrophobic drugs were encapsulated by the single O/W emulsion technique. Hydrophilic compounds required special modifications due to their poor oil solubility and tendency to escape to the outer aqueous phase during the emulsification and solvent evaporation steps. In total, three different strategies for incorporating hydrophilic drugs were employed: (1) O/W emulsion with partially water miscible solvent, (2) O/W emulsion with co-solvent (i.e. acetone, methanol, ethanol), or (3) W/O/W double emulsion. The encapsulation efficiencies and drug loading percentages were measured using UV/Vis spectroscopy and compared for the different synthesis methods. It was found that the double emulsion method resulted in the highest encapsulation efficiency and drug loading of the hydrophilic drug.

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Section: Introductionmentioning

confidence: 99%

Dual drug-loaded biodegradable Janus particles for simultaneous co-delivery of hydrophobic and hydrophilic compounds

Winkler

Barai

Tomassone

2019

Exp Biol Med (Maywood)

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“…All the particle size and size distribution reflected the average result of about 200 nm each, which were calculated according to the following formula [18]:…”

Section: Characterizationmentioning

confidence: 99%

Novel Janus magnetic micro particle synthesis and its applications as a demulsifier for breaking heavy crude oil and water emulsion

Ali

Zhang

et al. 2015

Fuel

114

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“…The performance of Fe 3 O 4 NSs is pertinently affected by their morphology, size, structure, and surface properties. For example, as carriers for targeted drug delivery, porous Fe 3 O 4 nanoparticles (NPs) are excellent due to their efficient delivery of theranostic agents and magnetic targeting ability . Moreover, porous Fe 3 O 4 NPs could improve both the drug loading ratio and the therapeutic efficiency .…”

Section: Introductionmentioning

confidence: 99%

“…For example, as carriers for targeted drug delivery, porous Fe 3 O 4 nanoparticles (NPs) are excellent due to their efficient delivery of theranostic agents and magnetic targeting ability. 12 Moreover, porous Fe 3 O 4 NPs could improve both the drug loading ratio and the therapeutic efficiency. 13 On the other hand, Fe 3 O 4 NPs doped with carbon significantly increased the conductivity when Fe 3 O 4 NPs were used for capacitor electrodes.…”

Section: ■ Introductionmentioning

confidence: 99%

Facile Fabrication of Composite Ag/Fe₃O₄ and Porous Fe₃O₄ Nanorods Based on Oblique Angle Codeposition

Huang

et al. 2021

J. Phys. Chem. C

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Composite Ag/Fe 3 O 4 and porous Fe 3 O 4 nanorods with controlled shape, size, composition, and porosity were fabricated by oblique angle codeposition as well as subsequent annealing and chemical etching. The codeposition supplies a way to evaporate two materials simultaneously to form composites, which would lead to a greater variety of nanorods. The composite Ag/Fe 3 O 4 and porous Fe 3 O 4 nanorods showed ferromagnetism, tunable optical properties, and strong carrier capability, which are believed to benefit the applications of biosensing, bioimaging, catalysis, targeted drug delivery, and therapeutic agent.

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Facile method for large scale synthesis of magnetic inorganic–organic hybrid anisotropic Janus particles

Cited by 22 publications

References 30 publications

Dual drug-loaded biodegradable Janus particles for simultaneous co-delivery of hydrophobic and hydrophilic compounds

Dual drug-loaded biodegradable Janus particles for simultaneous co-delivery of hydrophobic and hydrophilic compounds

Novel Janus magnetic micro particle synthesis and its applications as a demulsifier for breaking heavy crude oil and water emulsion

Facile Fabrication of Composite Ag/Fe₃O₄ and Porous Fe₃O₄ Nanorods Based on Oblique Angle Codeposition

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Facile method for large scale synthesis of magnetic inorganic–organic hybrid anisotropic Janus particles

Cited by 22 publications

References 30 publications

Dual drug-loaded biodegradable Janus particles for simultaneous co-delivery of hydrophobic and hydrophilic compounds

Dual drug-loaded biodegradable Janus particles for simultaneous co-delivery of hydrophobic and hydrophilic compounds

Novel Janus magnetic micro particle synthesis and its applications as a demulsifier for breaking heavy crude oil and water emulsion

Facile Fabrication of Composite Ag/Fe3O4 and Porous Fe3O4 Nanorods Based on Oblique Angle Codeposition

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Product

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Facile Fabrication of Composite Ag/Fe₃O₄ and Porous Fe₃O₄ Nanorods Based on Oblique Angle Codeposition