Facile method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by SiO2–H3PW12O40 in water

Reusable Nano Catalysed Synthesis of Heterocycles: An Overview

“…This methodology can be used to examine both aldehydes and ketones (aromatic and aliphatic). [43] Mirjalili et al [44] prepared 2,3-disubstituted quinoxalines 98 using the condensation of -diketones and 1,2-phenylenediamines. Nano-BF 3 SiO 2 was utilised as a catalyst in the synthesis of quinoxalines because it is a "green" and reusable solid acid.…”

Sulfonated magnetic spirulina nanobiomaterial as a novel and environmentally friendly catalyst for the synthesis of dihydroquinazolin-4(1H)-ones in aqueous medium

“…In recent years, there have been numerous reports on the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using diverse catalysts, such as Fe 3 O 4 @SiO 2 @TiO 2 -OSO 3 H 22 , 5,5'-Indigodisulfonic acid 23 , MCM-41-SO 3 H 24 , SCMNPs-Pr-HMTA-SO 3 H 25 , Al(H 2 PO 4 ) 3 26 , CoAl 2 O 4 Nanoparticles 27 , SnCl 2 .2H 2 O 28 , Fe 3 O 4 @EDTA/CuI 29 , SiO 2 –H 3 PW 12 O 40 30 , Co aminobenzamid@Al SBA 15 31 , Boric Acid Supported on Montmorillonites 32 . However, most of these procedures have certain limitations, such as lengthy procedures, harsh reaction conditions, hazardous and volatile organic solvents, application of expensive and unavailable reagents, and non-reusability of the catalyst.…”

An Efficient Green Protocol for Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones Using SBA‐16/GPTMS‐TSC‐CuIunder Solvent‐Free Conditions

“…There are a variety of methods in the literature for the synthesis of 2,3‐dihydroquinazolin‐4(1 H )‐one derivatives with their own merits and demerits: (a) condensation of anthranilamide with an aldehyde or ketone; (b) desulfurization of 2‐thioxo‐4(3 H )‐ quinazolinones; (c) reaction of isatoic anhydride with Schiff bases; (d) one‐step conversion of 2‐nitrobenzamides to 2,3‐dihydro‐4(1 H )‐quinazolinones; (e) condensation of anthranilamide with benzyl; (f) two‐step synthesis starting from isatoic anhydride and amines, then was annulated with ketones; (g) a one‐pot three‐component condensation of isatoic anhydride, aldehydes and amines . Of these, condensation of anthranilamide with an aldehyde or ketone is one of the simplest and direct methods of 2,3‐dihydroquinazolin‐4(1 H )‐onse preparation using a variety of homogeneous or heterogeneous catalysts such as molecular iodine (I 2 ), cyanuric chloride, morpholinoethanesulfonic acid NH 4 Cl, tetrabutylammonium bromide (TBAB), p‐sulfonic acid calix arene, [Al(H 2 PO 4 ) 3 ], [bmim]HSO 4 , Sc(OTf) 3 , ZrCl 4 , Y(OTf) 3 , BiBr 3 , NaHSO 4 , lactic acid, heteropoly acids, β‐cyclodextrin‐SO 3 H, SiO 2 ‐PPA, [PYC 4 SO 3 H][HSO 4 ]/A300SiO 2 , Fe 3 O 4 nanoparticles, cellulose‐SO 3 H, β‐cyclodextrin, Cu(NO 3 ) 2 /F 3 O 4 ‐DETA, amberlyst‐15, Fe 3 O 4 ‐chiff base of Cu(II), Sc(OTf) 3 fluorous bis(oxazolines), chiral SPINOL‐phosphoric acids, 3 A°MS, SiO 2 ‐H 3 PW 12 O 40 , TBAHS or by electrochemical reactions . Although, the reported synthetic protocols produce good results in many instances, some of them associated with at least one of the following imperfections: harsh reaction conditions, prolonged‐time period, unsatisfactory yields, and use of environmentally harmful solvent, expensive moisture‐sensitive catalysts, hazardous acid catalysts, high catalyst loading, expensive reagent, and tedious workup conditions.…”