Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine

Alkahtani, Saad A.; Mahmoud, Ashraf M.; Mahnashi, Mater H.; Alqarni, Ali O.; Alqahtani, Yahya S.; El-Wekil, Mohamed M.

doi:10.1016/j.microc.2021.105972

Cited by 40 publications

(14 citation statements)

References 66 publications

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“…Accordingly, it was determined that 1.96 electrons were contributed during the oxidation of hydroxychloroquine molecules when for irreversible processes α = 0.5. This result is very similar to the work done by the groups reported in the following published articles [ 34 , 48 , 51 , 54 , 55 ].…”

Section: Resultssupporting

confidence: 92%

Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine

et al. 2023

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In December 2019, the world experienced a new coronavirus, SARS-CoV-2, causing coronavirus disease 2019 originating from Wuhan.The virus has crossed national borders and now affects more than 200 countries and territories. Hydroxychloroquine has been considered as a drug capable of treating COVID-19. The objective of this work is to establish a simple platform for electrocatalytic detection of hydroxychloroquine in human urine samples and pharmaceutical samples (tablets) using a ZnO@CPE sensor constructed by simple and inexpensive hydrothermal methods using a square wave voltammetry method. The best results are obtained in a PBS electrolyte with irreversible behavior of the hydroxychloroquine complement and controlled by diffusion coupled with absorption phenomena. The ZnO@CPE shifts the oxidation potential of hydroxychloroquine with the formation of a single very intense peak at the position of Epa = 0.5 V/(vs Ag/AgCl) with a shift is ΔEp = 0.1 V(vs Ag/AgCl) compared to the unmodified electrode. The obtained ZnO@CPE hybrid nanocomposite was characterized by different techniques and showed excellent electrocatalytic activity and higher active surface area compared to the bare carbon paste electrode. Under the optimized experimental conditions, the ZnO@CPE sensor showed good analytical performance for the determination of trace amounts of hydroxychloroquine, a wide linearity range from 10 –3 M to 0.8 × 10 –6 M with a very low detection limit in the range of 1.33 × 10 –7 M, satisfactory selectivity, acceptable repeatability and reproducibility. The calculated recovery and coefficient of variation for the two samples analyzed are very satisfactory, ranging from 97.6 to 102% and 1.2 to 2.3% respectively. The proposed applied method and the fabricated sensor offer the possibility to analyze traces of hydroxychloroquine in real human urine and water samples. Graphical abstract Strategy for the electro-oxidation reaction of hydroxychloroquine on the electro-catalytic surface of the ZnO@Carbon graphite electrode and real-time detection of hydroxychloroquine.

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Section: Resultssupporting

confidence: 92%

Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine

et al. 2023

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“…The literature does not clearly report the nature of the two oxidation peaks presented. Several studies [8,13,17,18,38,39] show that the oxidation reaction of HCQ is pH-dependent. This fact makes possible some assumptions about the process from what is informed, based on the pKa values of the functional groups of the HCQ molecule.…”

Section: Electrochemical Performance Of Cnns/ementioning

confidence: 99%

“…Electrochemical sensors can be manufactured by using several materials, and in some cases, taking many steps through the synthesis of modifiers [17,18]. However, carbon paste stands out due to its ease of production, modification, and assembly on the electrode.…”

Section: Introductionmentioning

confidence: 99%

A Novel Carbon Nitride Nanosheets‐based Electrochemical Sensor for Determination of Hydroxychloroquine in Pharmaceutical Formulation and Synthetic Urine Samples

Silva

Sant’Anna

Gevaerd³

et al. 2021

Electroanalysis

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This study introduces modified carbon paste electrodes with carbon nitride nanosheets (CNNS) and outlines their application for the determination of hydroxychloroquine sulfate (HCQ) in tablets and synthetic urine samples. CNNS were synthesized by hydrothermal route (200°C, 10 h) using melamine and citric acid as their precursors. The carbon nitride nanosheets-based electrode (CNNS/E) presented a linear dynamic range for HCQ (LDR), ranging from 10.0 nmol l À 1 to 6.92 μmol l À 1 , and detection (LOD) and quantification limits (LOQ) of 0.16 nmol l À 1 and 0.52 nmol l À 1 , respectively. LOD and LOQ were calculated by the equations: LOD = 3(S d /b), and LOQ = 10(S d /b). The modified sensor presented excellent relative standard deviations for parameters such as repeatability (2.39 % and 1.87 %) and reproducibility (3.22 % and 2.32 %) in HCQ oxidation peaks (1 and 2). The CNNS/E has not shown significant variations in its anodic signal intensity in the presence of some organic and inorganic substances. It is worth bearing in mind that CNNS/E can be easily manufactured and the sensor has the lowest HCQ detection limits reported so far. The proposed sensor was successfully applied for HCQ determination in tablets and synthetic urine, showing good recovery values and an error of 0.60 % about comparative method in tablet samples, assuring the quality of the method.

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“…Compared to other sensors reported in the literature for DB, PA, AM, and DAC determination, low DLs are obtained for simultaneous determination of the four drugs in their mixture using a TU-SAMs sensor as illustrated in Table 3. 10,11,19,20,78–82 Also, the TU-SAMs sensor exhibits low DLs for DB, PA, AM, and DAC determination compared to other reported methods in the literature, Table S2 (ESI†). 8,9,29,30,35,36,43,44…”

Section: Resultsmentioning

confidence: 92%

“…3 Administration of the DAC (BMS 790052) drug results in decreased levels of serum HCV RNA by about two orders of magnitude within 6 h. 4 Quantitative determination of DAC was reported by some methods including UV spectrophotometry, 5 chromatography, [6][7][8][9] and electrochemistry. 10,11 Effective assays without sample pretreatment, that are cost effective, time-saving, sensitive, and a simple approach are the advantages of the electrochemical methods compared to other cited methods. In human serum the concentration of anti-hepatitis C drugs changes over time, thus it is better to use the electrochemical method for analysis to continuously monitor its variation.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical sensing of dobutamine, paracetamol, amlodipine, and daclatasvir in serum based on thiourea SAMs over nano-gold particles–CNTs composite

2022

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Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine

Cited by 40 publications

References 66 publications

Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine

Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine

A Novel Carbon Nitride Nanosheets‐based Electrochemical Sensor for Determination of Hydroxychloroquine in Pharmaceutical Formulation and Synthetic Urine Samples

Electrochemical sensing of dobutamine, paracetamol, amlodipine, and daclatasvir in serum based on thiourea SAMs over nano-gold particles–CNTs composite

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