FACILE ONE-POT SYNTHESIS OF 4-ARYL-3-METHYL-1-PHENYLPYRAZOLO[3,4-b]-[1,5]BENZOTHIAZEPINE DERIVATIVES VIA A REGIOSELECTIVE NUCLEOPHILIC ADDITION

Latif, Fawi M. Abd El; Rady, Eman A. El

doi:10.1080/10426500490274646

Cited by 8 publications

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“…Recently, the Biginelli reaction was developed for the synthesis of [1,2,4]triazolo[1,5‐ a ]pyrimidine and its derivatives because of their remarkable diverse therapeutic and pharmacological activities such as analgesic, anticonvulsant, anti‐inflammatory, antimalarials, antimicrobial, and antifungal effects . Owing to the demand for an environmentally benign, green methodologies and continuing the interest for the synthesis of heterocyclic compounds , the synthesis of [1,2,4]triazolo[1,5‐ a ]pyrimidine via a three‐component system under reflux without any catalyst have been reported herein (Scheme ).…”

Section: Introductionmentioning

confidence: 99%

Three‐Component Uncatalyzed Eco‐Friendly Reactions for One‐Pot Synthesis of 4,7‐Dihydro[1,2,4]triazolo[1,5‐a]pyrimidine Derivatives

Rady

2013

Journal of Heterocyclic Chem

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A three‐component system of one‐pot synthesis of [1,2,4]triazolo[1,5‐a]pyrimidine derivatives using condensation of 1,3‐dicarbonyl compounds, aldehydes, and 5‐amino[1,2,4]triazole in ethanol without any catalyst was reported in high yields via simple, efficient, and environmentally friendly process. The method reported herein considered a green process; this method has significant advantages of simple workup procedure, excellent yield, minimal environmental pollution, and short reaction time over classical reported methods.

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Section: Introductionmentioning

confidence: 99%