Facile One-Pot Synthesis of N-acyl-1H-1,2,3-benzotriazoles from Internal and Terminal Olefinic Fatty Acids and Their Antimicrobial Screening

Benzotriazole: An overview on its versatile biological behavior

“…Potential antibacterial activity was also reported for N-acyl-1H-benzotriazoles substituted with olefinic fatty acids (3aed) ( Fig. 4) [39].…”

“…All prepared compounds showed no cytotoxicity and were tested against M. tb and some other microorganisms, such as bacteria and fungi. As result, compound (39), emerged, showing a promising activity against M. tb (MIC ¼ 3.125 mg/ml). Moreover, it resulted active against some bacteria (MIC ¼ 0.1 mg/ml on Escherichia coli) and fungi (MIC ¼ 0.5 mg/ml on Aspergillus niger), (Fig.…”

An updated review of fatty acid residue-tethered heterocyclic compounds: synthetic strategies and biological significance

“…Furthermore, Abdul Rauf and co-workers reported one pot synthesis of fatty –N-acyl-1 H -1,2,3 benzotriazoles 126a–d by stirring benzotriazoles 123, thionylchloride 124 and fatty acids 125a–d in methylene chloride at room temperature 54 ( Scheme 26 ).…”

Recent Development of Benzotriazole-based Medicinal Drugs

“…Heterocyclic molecules usually containing N, O or S heteroatom in their cyclic structures as one of the most active classes of compounds possess a wide spectrum of biological activities, and have showed large potentiality in pharmaceutical science (Figure 3). The introduction of benzotriazole ring into other heterocyclic scaffolds to form some new structural compounds with improved antifungal ability has attracted increasing attention in medicinal chemistry, and this field is worthy of further investigations [71].…”