Facile preparation of a strong chitosan-silk biocomposite film

Huang, Jiwei; Qin, Jianzhong; Zhang, Peng; Chen, Xuanmo; You, Xinran; Zhang, Feng; Zuo, Baoqi; Mu, Yao

doi:10.1016/j.carbpol.2019.115515

Cited by 58 publications

(28 citation statements)

References 45 publications

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“…These range from modifications of deacetylation degree, pH, and solvent type, to forming composites with plasticizers, proteins, and polysaccharides such as cellulose and starch. [21][22][23][24][25] Another strategy involves modification to improve surface chemistry, while maintaining bulk properties, leading to enhanced functionality, performance, and increased stability. Plasma treatment (N 2 /Ar) of chitosan membranes increases the surface roughness and improves cell adhesion and proliferation, while ozone or UV irradiation can be used for surface modification leading to depolymerization of chitosan.…”

Section: Introductionmentioning

confidence: 99%

Facile fabrication and nanoscale assembly of polydopamine-functionalized, flexible chitosan films

Brooks

Imran

Pradhan

et al. 2021

Journal of Bioactive and Compatible Polymers

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Substrates that are simultaneously thin, strong, optically transparent, and biocompatible have diverse applications in a range of fundamental and applied fields. While nature-derived materials offer advantages of sustainability and inherent biocompatibility compared to synthetic polymers, their brittleness and swelling, as well as surface charge and chemical functionalization non-conducive to cell growth, can hinder widespread application. In this work, we discuss the fabrication and systematic characterization of polydopamine-coated chitosan thin films. Chitosan is a widely used, partially deacetylated form of chitin, derived from crustaceans and arthropods. Polydopamine (PDA) is derived from chemistries mimicking mussel foot adhesive proteins. A facile dip-coating process of thin and flexible, uncrosslinked chitosan films in aqueous dopamine solutions leads to dramatic changes in physical and chemical properties. We show how the PDA forms time-dependent assemblies on the film surfaces, affecting surface roughness, hydrophilicity, and mechanical strength. Coating the surface for even a few seconds provides functional changes to the films. Our results shows that the optimal coating time is on the order of few hours, whereby the films are optically transparent with excellent extensibility and Young’s modulus, while further coating reduces the benefits of this surface coating. These materials are biocompatible, serving as substrates for cell adhesion and growth while maintaining good viability. Overall, these findings give insight to the effects of PDA assembly on surfaces, and illustrate how a simple, quick, and robust bioinspired coating process can prime substrates for biomedical applications such as tissue engineering, biosensing, and wound healing.

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Section: Introductionmentioning

confidence: 99%

Facile fabrication and nanoscale assembly of polydopamine-functionalized, flexible chitosan films

Brooks

Imran

Pradhan

et al. 2021

Journal of Bioactive and Compatible Polymers

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“…Moreover, chitosan demonstrates film-forming properties and is primarily utilized in food packing and biomedical applications [5]. Chitosan films exhibit good biocompatibility and antimicrobial property [25,26]. Upon adding conductive elements, chitosan films can be designed to possess an electrical conductivity near native tissues and regulate the differentiation of stem cells [2,8,27].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive and Conductive Chitosan-Polyurethane Biocompatible Thin Films with Potential Coating Application

Tsai

et al. 2021

Polymers

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Conductive thin films have great potential for application in the biomedical field. Herein, we designed thermoresponsive and conductive thin films with hydrophilicity, strain sensing, and biocompatibility. The crosslinked dense thin films were synthesized and prepared through a Schiff base reaction and ionic interaction from dialdehyde polyurethane, N-carboxyethyl chitosan, and double-bonded chitosan grafted polypyrrole. The thin films were air-dried under room temperature. These thin films showed hydrophilicity and conductivity (above 2.50 mS/cm) as well as responsiveness to the deformation. The tensile break strength (9.72 MPa to 15.07 MPa) and tensile elongation (5.76% to 12.77%) of conductive thin films were enhanced by heating them from 25 °C to 50 °C. In addition, neural stem cells cultured on the conductive thin films showed cell clustering, proliferation, and differentiation. The application of the materials as a conductive surface coating was verified by different coating strategies. The conductive thin films are potential candidates for surface modification and biocompatible polymer coating.

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“…Additionally, it can improve water solubility, control delivery, facilitate absorption, and reduce toxicity and cost [18]. Chitosan (CS) is a natural cationic polysaccharide with good biocompatibility, low toxicity, and excellent biodegradability, and is considered an ideal option for food packaging [19][20][21][22]. It has been reported that CS, as a nanoparticle (NP) carrier, can encapsulate EOs and improve their stability.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Cinnamomum Essential Oil–Chitosan Nanocomposites: Physical, Structural, and Antioxidant Activities

Huang

Liu

et al. 2020

Processes

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In this study, different amounts of cinnamomum essential oil (CEO) were encapsulated in chitosan nanoparticles (NPs) (CS-NPs) through oil-in-water emulsification and ionic gelation. An ultraviolet-visible spectrophotometer, Fourier-transform infrared spectroscopy, synchronous thermal analysis, and X-ray diffraction were employed to analyze the CEO encapsulation. As observed by field-emission scanning electron microscopy, NP size analysis and zeta potential, the prepared CS-NPs, containing CEO (CS-CEO), were spherical with uniformly distributed sizes (diameters: 190–340 nm). The ranges of encapsulation efficiency (EE) and loading capacity (LC) were 4.6–32.9% and 0.9–10.4%, with variations in the starting weight ratio of CEO to CS from 0.11 to 0.53 (w/w). It was also found that the antioxidant activity of the CS-NPs loaded with CEO increased as the EE increased. The active ingredients of the CEO were prevented from being volatilized, significantly improving the chemical stability. The antioxidant activity of CS-CEO was higher than that of the free CEO. These results indicate the promising potential of CS-CEO as an antioxidant for food processing, and packaging applications.

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Facile preparation of a strong chitosan-silk biocomposite film

Cited by 58 publications

References 45 publications

Facile fabrication and nanoscale assembly of polydopamine-functionalized, flexible chitosan films

Facile fabrication and nanoscale assembly of polydopamine-functionalized, flexible chitosan films

Thermoresponsive and Conductive Chitosan-Polyurethane Biocompatible Thin Films with Potential Coating Application

Preparation and Characterization of Cinnamomum Essential Oil–Chitosan Nanocomposites: Physical, Structural, and Antioxidant Activities

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