Facile preparation of amino acid-assisted Fe3O4 nanoparticles for low-density lipoprotein cholesterol removal

Othi, Nisar Ali; Hanan, Abdul; Solangi, Muhammad Yameen; AlSalhi, Mohamad S.; Devanesan, Sandhanasamy; Shar, Muhammad Ali; Bhutto, Muhammad Aqeel; Abro, Muhammad Ishaque; Aftab, Umair

doi:10.1007/s11696-023-03040-7

Cited by 6 publications

(1 citation statement)

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“…Presently, six prevalent LDL apheresis technologies are accessible, with four relying on the adsorption principle—dextran sulfate adsorption, dextran sulfate direct perfusion, polyacrylate-coated polyacrylamide direct perfusion and immune-adsorption [ 16 , 17 , 18 ]—which underscores the pivotal role of the adsorption material as a determining factor in the therapeutic efficacy of LDL-apheresis systems. Consequently, considerable focus has been directed towards exploring cost-effective and efficient adsorbents, resulting in the emergence of diverse LDL ligands, including antibodies [ 19 , 20 ], heparin [ 21 , 22 , 23 , 24 ], chondroitin sulfate [ 25 , 26 ], amino acid [ 27 ], phospholipids [ 28 , 29 ], chitosan derivatives [ 30 , 31 ] and others. Typically, a predominant feature of low-density lipoprotein (LDL) adsorption materials involves the incorporation of anionic characteristics.…”

Section: Introductionmentioning

confidence: 99%

Facile Preparation of β-Cyclodextrin-Modified Polysulfone Membrane for Low-Density Lipoprotein Adsorption via Dopamine Self-Assembly and Schiff Base Reaction

Fang,

Zhao,

Wang

et al. 2024

Materials

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A facile method for the immobilization of β-cyclodextrin on polysulfone membranes with the aim of selectively adsorbing low-density lipoprotein (LDL) was established, which is based on the self-assembly of dopamine on the membrane followed by the Schiff base reaction with mono-(6-ethanediamine-6-deoxy)-β-cyclodextrin. The surface modification processes were validated using X-ray photoelectron spectroscopy and attenuated total reflectance Fourier-transform infrared spectroscopy. Surface wettability and surface charge of the membranes were investigated through the water contact angle and zeta potential analysis. The cyclodextrin-modified polysulfone membrane (PSF-CD) showed good resistance to protein solutions, as shown by the measurement of BSA adsorption. The assessment of BSA adsorption revealed that the cyclodextrin-modified polysulfone membrane (PSF-CD) exhibited excellent resistance to protein solutions. To investigate the adsorption and desorption behaviors of the membranes in single-protein or binary-protein solutions, an enzyme-linked immunosorbent assay was employed. The results revealed that the PSF-CD possessed remarkable adsorption capacity and higher affinity for LDL in both single-protein and binary-protein solutions, rendering it a suitable material for LDL apheresis.

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