Facile Preparation of Biocompatible and Robust Fluorescent Polymeric Nanoparticles via PEGylation and Cross-Linking

Li, Haiyin; Zhang, Xiqi; Zhang, Xiaoyong; Wang, Ke; Liu, Hongliang; Wei, Yen

doi:10.1021/am5085308

Cited by 18 publications

(17 citation statements)

References 36 publications

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“…Moreover, a passive exploitation of this characteristic leaky vasculature has allowed an increased delivery and accumulation of nanomedicines through sub-endothelial space. Additionally, targeting moieties on nanoparticles’ surface may allow an active accumulation and a controlled drug release into the diseased cells and tissues, reducing toxicity and side-effects [ [23] , [24] , [25] ]. Therefore, many nanomedicines were developed with the aim to treat diseases with an inflammatory background, including cancer [ 26 , 27 ], cardiovascular pathologies [ [28] , [29] , [30] ], autoimmune diseases [ 31 ], metabolic syndrome [ 32 ], neurodegenerative diseases [ 22 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Advanced nanomedicines for the treatment of inflammatory diseases

Brusini

Varna

Couvreur

2020

Advanced Drug Delivery Reviews

148

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Inflammation, a common feature of many diseases, is an essential immune response that enables survival and maintains tissue homeostasis. However, in some conditions, the inflammatory process becomes detrimental, contributing to the pathogenesis of a disease. Targeting inflammation by using nanomedicines (i.e. nanoparticles loaded with a therapeutic active principle), either through the recognition of molecules overexpressed onto the surface of activated macrophages or endothelial cells, or through enhanced vasculature permeability, or even through biomimicry, offers a promising solution for the treatment of inflammatory diseases. After providing a brief insight on the pathophysiology of inflammation and current therapeutic strategies, the review will discuss, at a pre-clinical stage, the main innovative nanomedicine approaches that have been proposed in the past five years for the resolution of inflammatory disorders, finally focusing on those currently in clinical trials.

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Section: Introductionmentioning

confidence: 99%

Advanced nanomedicines for the treatment of inflammatory diseases

Brusini

Varna

Couvreur

2020

Advanced Drug Delivery Reviews

148

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“…Poly(ethylene glycol) (PEG) is a hydrophilic polymer with a flexible nature that is often selected as the shell-forming segments and can endow the nanoparticles with a stealth character in the blood compartment, thereby achieving long circulation times. [36][37][38][39][40][41][42] More importantly, the PEGylation of nanoparticles guarantees a superb biocompatibility. 43 In this case, the PEGylation of GCC NPs should produce a promising candidate for tracing and biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging

et al. 2015

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PEGylated red fluorescent nanoparticles with excellent biocompatibility and photostablity were facilely prepared from nonluminous materials: first red fluorescent nanoparticles (GCC NPs) were robustly prepared from chitosan and glutaraldehyde; then the amino groups and hydroxyl groups on GCC NPs surface were modified with 2-bromoisobutyryl bromide to get the GCC-Br, which was employed as the nanoparticles initiator in ATRP system to finally obtain the GCC-poly(PEGMA) conjugates. The resulted GCC-poly(PEGMA) can emit biofavorable deep red luminescence, which was quite stable and anti-photobleaching. Furthermore, GCC-poly(PEGMA) demonstrated excellent biocompatibility and water dispersibility due to the PEGMA chains conjugated on the surface; and the abundant hydroxyl groups on the surface can be further functionalized with diverse other groups or large biomolecules. This construction method demonstrated huge superiorities in its simple strategy and economic value, and their successful cellular imaging applications made them highly potential for various biomedical applications. Abstract Biocompatible and photostable PEGylated red fluorescent nanoparticles were prepared via surface-initiated ATRP and their cellular imaging application was successfully demonstrated.

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“…Among the organic nanomaterials, nanogels constructed by covalently crosslinked polymeric network incorporating fluorophore groups are reasonably supposed to have higher chemical and mechanical stability [12,15] than those constructed through van der Waals forces [1]. For nanogel synthesis, several methods have been developed, including crosslinking the pre-synthesized linear block copolymers by coupling their functional side groups [16,17,18,19], initiating difunctional monomer by using a polymeric macroinitiator, and polymerizing difunctional monomers in a nano-sized emulsion [20,21,22], etc. Recently, the utility of core–shell star-shaped block copolymers as precursors has emerged as a powerful strategy to construct nanoobjects with high controllability over the size and uniformity [23,24].…”

Section: Introductionmentioning

confidence: 99%

A Facile Approach towards Fluorescent Nanogels with AIE-Active Spacers

Feng¹,

Fang²,

Guan³

et al. 2018

Polymers

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A facile and efficient approach for design and synthesis of organic fluorescent nanogels has been developed by using a pre-synthesized polymeric precursor. This strategy is achieved by two key steps: (i) precise synthesis of core–shell star-shaped block copolymers with crosslinkable AIEgen-precursor (AIEgen: aggregation induced emission luminogen) as pending groups on the inner blocks; (ii) gelation of the inner blocks by coupling the AIEgen-precursor moieties to generate AIE-active spacers, and thus, fluorescent nanogel. By using this strategy, a series of star-shaped block copolymers with benzophenone groups pending on the inner blocks were synthesized by grafting from a hexafunctional initiator through atom transfer radical copolymerization (ATRP) of 4-benzoylphenyl methacrylate (BPMA) or 2-(4-benzoylphenoxy)ethyl methacrylate (BPOEMA) with methyl methacrylate (MMA) and tert -butyldimethylsilyl-protected 2-hydroxyethyl methacrylate (ProHEMA) followed by a sequential ATRP to grow PMMA or PProHEMA. The pendent benzophenone groups were coupled by McMurry reaction to generate tetraphenylethylene (TPE) groups which served as AIE-active spacers, affording a fluorescent nanogel. The nanogel showed strong emission not only at aggregated state but also in dilute solution due to the strongly restricted inter- and intramolecular movement of TPE moiety in the crosslinked polymeric network. The nanogel has been used as a fluorescent macromolecular additive to fabricate fluorescent film.

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Facile Preparation of Biocompatible and Robust Fluorescent Polymeric Nanoparticles via PEGylation and Cross-Linking

Cited by 18 publications

References 36 publications

Advanced nanomedicines for the treatment of inflammatory diseases

Advanced nanomedicines for the treatment of inflammatory diseases

Preparation of biocompatible and photostable PEGylated red fluorescent nanoparticles for cellular imaging

A Facile Approach towards Fluorescent Nanogels with AIE-Active Spacers

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