Facile preparation of magnetic molecularly imprinted polymers for the selective extraction and determination of dexamethasone in skincare cosmetics using HPLC

Abstract

Dexamethasone-imprinted polymers were fabricated by reversible addition-fragmentation chain transfer polymerization on the surface of magnetic nanoparticles under mild polymerization conditions, which exhibited a narrow polydispersity and high selectivity for dexamethasone extraction. The dexamethasone-imprinted polymers were characterized by scanning electron microscopy, transmission electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction, energy dispersive spectrometry, and vibrating sample magnetometry. The adsorption performance was evaluated by static adsorption, kinetic adsorption and selectivity tests. The results confirmed the successful construction of an imprinted polymer layer on the surface of the magnetic nanoparticles, which benefits the characteristics of high adsorption capacity, fast mass transfer, specific molecular recognition, and simple magnetic separation. Combined with high-performance liquid chromatography, molecularly imprinted polymers as magnetic extraction sorbents were used for the rapid and selective extraction and determination of dexamethasone in skincare cosmetic samples, with the accuracies of the spiked samples ranging from 93.8 to 97.6%. The relative standard deviations were less than 2.7%. The limit of detection and limit of quantification were 0.05 and 0.20 μg/mL, respectively. The developed method was simple, fast and highly selective and could be a promising method for dexamethasone monitoring in cosmetic products.

Solid Dosage Forms of Dexamethasone Sodium Phosphate Intended for Pediatric Use: Formulation and Stability Studies

“…On surveying the literature, there are numerous analytical approaches to determine DSP in various samples of biological, animal-derived foodstuffs, etc., in which liquid chromatography (LC), coupled with spectrophotometric (UV) [8] or mass spectrometric detection (MS), is the predominant analytical technique [9][10][11]. Concerning the sample preparation, several efforts have been made to isolate DSP from complicated matrices involving solid phase extraction [12,13], matrix solid phase dispersion [9,14], liquid phase microextraction (LPME) [15], QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) [16,17] and simple protein precipitation [18]. Most of them are laborious, time-consuming and require large amounts of consumables.…”

“…A set of foods, such as different types of chocolate, hazelnut praline and strawberry/cherry syrup, are used to produce DSP formulations without losing their potency or stability. An analytical method was applied to estimate the dissolution profile and to support the in vitro simulation of gastrointestinal digestion Pharmaceutics 2020, 12,354 3 of 18 experiments. The proposed analytical scheme has been validated according to International Conference on Harmonization's (ICH) guidelines.…”

Preparation and evaluation of temperature and magnetic dual‐responsive molecularly imprinted polymers for the specific enrichment of formononetin

“…Meanwhile, stimuli‐responsive MIPs, also known as environmental responsive polymers or intelligent polymers, have attracted considerable attention due to their molecular recognition specificity responding to specific external stimuli . Stimuli‐responsive‐MIPs can be controlled by changing the magnetic field, temperature and they are based on a considerable change in their properties, including molecular chain structure, solubility, surface structure, swelling or dissociation behavior .…”

“…Stimuli‐responsive‐MIPs can be controlled by changing the magnetic field, temperature and they are based on a considerable change in their properties, including molecular chain structure, solubility, surface structure, swelling or dissociation behavior . In particular, magnetic‐sensing and thermo‐responsive MIPs have been developed and displayed broad application prospects in drug delivery systems, sensors, and separation technology . Magnetic molecularly imprinted polymers (MMIPs) are prepared by coating MIP film on the surface of magnetic nanoparticles, such as Fe 3 O 4 and γ‐Fe 3 O 4 , resulting in MMIPs combining the advantages of molecular recognition and fast magnetic separation .…”

Cellulose membrane modified with polypyrrole as an extraction device for the determination of emerging contaminants in river water with gas chromatography–mass spectrometry

“…These compounds are typically persistent in the Article Related Abbreviations: APS, ammonium persulfate; CM-PPy, cellulose membrane modified with polypyrrole; EC, emerging contaminant; PPy, polypyrrole environment and may be prone to bioaccumulation in organisms in the trophic chain [4]. This can lead to adverse effects on exposed organisms even at very low concentrations (μg/L and ng/L), for instance, the feminization of fish [5] and amphibians [6], inhibition of the growth of human embryonic cells [7], and antibiotic resistance [8,9]. Wastewater effluent is a major source of ECs in the environment, in addition to surface and agricultural run-off.…”