Facile preparation of open-cellular porous poly (l-lactic acid) scaffold by supercritical carbon dioxide foaming for potential tissue engineering applications

Kuang, Tairong; Chen, Feng; Chang, Lingqian; Zhao, Yanan; Fu, Dajiong; Gong, Xiao; Peng, Xiangfang

doi:10.1016/j.cej.2016.09.023

Cited by 200 publications

(112 citation statements)

References 35 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…The promising candidates for small diameter vascular grafts belong to PCUs, because of their superior biostability and their mechanical compliance similar to natural arteries . In comparison, biodegradable scaffolds usually suffer from the mismatch between the tissue ingrowth and the material degradation, and thus are less mechanically reliable. The functional PCUs we developed in this study cannot serve as bulk materials for small‐diameter grafts either, because the relatively high water uptake due to their hydrophilic PEG segments can weaken the materials.…”

Section: Discussionmentioning

confidence: 99%

Toward endothelialization via vascular endothelial growth factor immobilization on cell‐repelling functional polyurethanes

Liao

Yang

et al. 2018

J Biomed Mater Res

View full text Add to dashboard Cite

We screened a family of nonspecific cell-repelling polyurethanes (PUs) whose backbones are attached with epoxy group-terminated polyethylene glycol (PEG) side chains. Water incubation of the PU films (with 9.2-31.1 wt % PEG) caused a surface enrichment of PEG chains where vascular endothelial growth factor (VEGF) was grafted by forming secondary amine linkages between VEGF molecules and the PEG spacer. These linkages are still ionizable similar to original primary amines in VEGF, thereby retaining the original charge distribution on VEGF macromolecules. This charge conservation together with PEG steric repulsion helped to preserve VEGF conformation and bioactivity. The PU substrates with suitable hard segments contents and VEGF surface densities can selectively induce endothelial cells (ECs) adhesion and proliferation toward endothelialization. Moreover, the PU substrates, even grafted with fibrinogen (Fg), cannot trigger platelet adhesion and deformation, suggesting an inactive conformation of the grafted Fg. Thus enough antithrombogenicity of the PU substrates could be expected before full endothelialization. These PU materials might be applied onto the lumens of vascular grafts, potentially stimulating luminal endothelialization in vivo.

show abstract

Section: Discussionmentioning

confidence: 99%

Toward endothelialization via vascular endothelial growth factor immobilization on cell‐repelling functional polyurethanes

Liao

Yang

et al. 2018

J Biomed Mater Res

View full text Add to dashboard Cite

show abstract

“…Although both enantiomers are used for biomedical applications, PLLA is preferred as it has excellent mechanical strength and it is naturally present in human muscle; therefore, it has better compatibility to the human body (Kuang et al, 2017). Although both enantiomers are used for biomedical applications, PLLA is preferred as it has excellent mechanical strength and it is naturally present in human muscle; therefore, it has better compatibility to the human body (Kuang et al, 2017).…”

Section: Polylactic Acidmentioning

confidence: 99%

“…Lactic acid is a simple chiral molecule existing in two enantiomers as Llactic acid (PLLA) and DL-lactic acid (PDLLA). Although both enantiomers are used for biomedical applications, PLLA is preferred as it has excellent mechanical strength and it is naturally present in human muscle; therefore, it has better compatibility to the human body (Kuang et al, 2017). PLA degrades by nonenzymatic hydrolysis, and its by-products are metabolically innocuous (Gupta, Revagade, & Hilborn, 2007).…”

Section: Polylactic Acidmentioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

View full text Add to dashboard Cite

The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.biocompatibility, biocomposites, biopolymers, nanodiamond, scaffold

show abstract

“…Several methods have proven to be effective at increasing the open‐cell content during the PLA foaming process, such as adding additives that can be leached out after foaming, [ 17 ] using pulsed ultrasound to rupture the cell wall after foaming, [ 18 ] applying a pressure‐induced flow method to the samples before foaming to enhance the crystallization and heterogenous nucleation of the PLA in scCO 2 foaming, [ 19 ] and the blending of two semicrystalline polymers with different crystallization temperatures ( T c ) to achieve a structural inhomogeneity in a polymer matrix consisting of hard and soft regions. [ 20,21 ] Yu et al prepared PLA/poly(butylene succinate) (PBS) blended foams with an open‐cell content of up to 97% because the interface of PLA/PBS is good for cell nucleation, and the viscosity of PBS is low, which is conducive to the formation of channels with connecting cells and the formation of an open‐cell structure.…”

Section: Introductionmentioning

confidence: 99%

Solvent‐Free Generation of Foamed Microcapillary Films with a Dual Network of Interconnected Pores and Internal Channels

Zhao

Zheng

et al. 2020

Macro Materials & Eng

View full text Add to dashboard Cite

A dual‐pore network is favored in applications such as tissue engineering scaffolds. In this paper, foamed microcapillary films (FMCFs) are prepared based on a poly(lactic acid)/poly(butylene succinate) blend using melt extrusion and batch foaming with supercritical carbon dioxide. Such films are characterized by multiple hollow microcapillaries (diameter of 100–360 µm) connected with cells (size of 3–194 µm, open‐cell content of over 80%) within the scaffold. By plugging the ends of the MCF before foaming, the formation of a solid skin layer is successfully avoided. Furthermore, the diameter of the microcapillaries of an FMCF can be adjusted using the designed foaming strategy. The effects of the foaming condition on the FMCF foaming behavior are also investigated. When other conditions are fixed, the foaming behavior changes dramatically when the foaming temperature changes within the range of 120–123 °C.

show abstract

Facile preparation of open-cellular porous poly (l-lactic acid) scaffold by supercritical carbon dioxide foaming for potential tissue engineering applications

Cited by 200 publications

References 35 publications

Toward endothelialization via vascular endothelial growth factor immobilization on cell‐repelling functional polyurethanes

Toward endothelialization via vascular endothelial growth factor immobilization on cell‐repelling functional polyurethanes

Nanodiamond in composite: Biomedical application

Solvent‐Free Generation of Foamed Microcapillary Films with a Dual Network of Interconnected Pores and Internal Channels

Contact Info

Product

Resources

About