It is essential to design and exploit high-efficiency denitration catalysts at low temperatures (100−300 °C). In this article, we propose an effective strategy to fabricate a series of catalysts by loading MnO x onto TiO x nanorod arrays with the solimpregnation method (denoted as Mn/TiNR catalysts), which show promising lowtemperature denitration efficiency in the temperature range of 100−300 °C. By the characterizations of physical properties and chemical compositions, it is found that TiO x nanorod arrays provide a high surface area to load the active sites and improve the interaction between Ti and Mn elements. In comparison with its counterpart that is prepared with a similar approach using the sol that contains both Mn and Ti (Mn−Ti catalysts), the Mn/TiNR catalysts have apparent advantages on the content of surface chemical oxygen, promoting the "fast SCR" reaction. This work provides an effective designation strategy for developing low-temperature selective catalytic reduction (SCR) catalysts via optimizing the interaction of active ingredients.