Facile separation of enantiomers via covalent organic framework bonded stationary phase

Enhanced Chiral Recognition Abilities of Cyclodextrin Covalent Organic Frameworks via Chiral/Achiral Functional Modification

“…Furthermore, the transmission electron microscopy (TEM) images depict the overlapping cubic slice morphology for the modified β-CD COFs (Figure 3). The morphology is consistent with that of β-CD COF BPDA , 24 further demonstrating that the crystallinity and morphology of β-CD COF BPDA was well preserved during the modification.…”

“…β-CD COF BPDA was synthesized according to the reported procedures (Figure S1). 24 Equal volume of BPDA (100 mmol L −1 , dissolved in THF) and Am7CD (40 mmol L −1 , dissolved in deionized water) solutions were mixed as a homogeneous solution, with acetic acid (180 mmol L −1 ) as the catalyst. The mixture was reacted at room temperature for 48 h. After the reaction, the precipitate was collected by centrifugation.…”

“…The massive hydroxyl and amino groups on the skeleton are amenable to carry out modification. It has been reported that β-CD COFs have excellent enantioseparation performance as CSP in high-performance liquid chromatography (HPLC), gas chromatography, and capillary electrochromatography (CEC). , To further broaden the versatility of the separated drugs and improve the separation efficiency, we propose two functional post-modification schemes to construct novel β-CD COFs in this work.…”

Beta‐cyclodextrin covalent organic framework coated silica composite as chiral stationary phase for high‐performance liquid chromatographic separation

“…Indeed, the design and construction of chiral COF materials is a current research hotspot [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. It has been demonstrated that chiral COFs can be used as effective chiral stationary phases for enantioselective separations in HPLC [26][27][28][29][30][31], GC [32][33][34], and CEC [35][36][37].…”