Facile synthesis and characterization of polyaniline (PANI) – Aluminium oxide (Al2O3) nanocomposites by using chemical oxidative polymerization

Development of eco-friendly and biodegradable package materials is an important goal of modern science and international industry. Poly(lactic)-co-glycolic acid (PLGA) is suitable for this purpose. However, biocompatible materials may be contaminated with bacteria. This problem may be solved by the addition of metal oxides nanoparticles (NPs) with antibacterial properties. Although metal oxides NPs often show cytotoxicity against plant and mammalian cells, a new nanocomposite based on PLGA and aluminum oxide (Al2O3) NPs has been developed. The PLGA/Al2O3 NP composite has pronounced antibacterial properties. The addition of Al2O3 NPs 0.01% inhibited growth of E. coli for >50%. The antimicrobial effect of Al2O3 NPs is implemented through the generation of reactive oxygen species and damage of bacterial proteins and DNA. The biocompatibility of the nanocomposite with plant and mammalian cells was studied. The PLGA/Al2O3 NP composite did not influence the growth and development of tomatoes and cucumbers. PLGA and its composite with Al2O3 NPs 0.001–0.1% did not influence viability and proliferation of mammalian cells, on their density or substrate colonization rate. The developed nanocomposite has controlled mechanical properties, high antibacterial activity and high biocompatibility, which makes it an attractive candidate for building and food package material manufacture and agriculture.

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A Mini Review of Antibacterial Properties of Al2O3 Nanoparticles

Gudkov

Burmistrov

Smirnova

et al. 2022

Nanomaterials

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Bacterial antibiotic resistance is one of the most serious modern biomedical problems that prioritizes the search for new agents to combat bacterial pathogens. It is known that nanoparticles of many metals and metal oxides can have an antibacterial effect. However, the antibacterial efficacy of aluminum oxide nanoparticles has been studied little compared to the well-known antimicrobial properties of nanoparticles of oxides of metals such as zinc, silver, iron, and copper. In this review, we have focused on the experimental studies accumulated to date demonstrating the antibacterial effect of aluminum oxide nanoparticles. The review discusses the main ways of synthesis and modification of these nanoparticles, provides the proposed mechanisms of their antibacterial action against gram-positive and gram-negative bacteria, and also compares the antibacterial efficacy depending on morphological characteristics. We have also partially considered the activity of aluminum oxide nanoparticles against water microalgae and fungi. In general, a more detailed study of the antibacterial properties of aluminum oxide nanoparticles is of great interest due to their low toxicity to eukaryotic cells.

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Facile synthesis and characterization of polyaniline (PANI) – Aluminium oxide (Al2O3) nanocomposites by using chemical oxidative polymerization

Cited by 3 publications

References 9 publications

A review on metal oxide-doped polyaniline nanocomposites

A review on metal oxide-doped polyaniline nanocomposites

New Structural Nanocomposite Based on PLGA and Al2O3 NPs as a Balance between Antibacterial Activity and Biocompatibility with Eukaryotic Cells

A Mini Review of Antibacterial Properties of Al2O3 Nanoparticles

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