Facile synthesis and characterization of cross-linked chitosan quaternary ammonium salt membrane for antibacterial coating of piezoelectric sensors

Li, Jie; Xie, Bing; Xia, Kai; Zhao, Chunmao; Li, Yingchun; Liu, Dong; Han, Jing

doi:10.1016/j.ijbiomac.2018.08.153

Cited by 49 publications

(29 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quaternary ammonium chitosan salt also has better antibacterial, biocompatibility, biodegradability, non-toxicity, and biological effects, as well as innate mucoadhesiveness and the ability to penetrate mucus layers and bind to epithelial surfaces. Therefore, it is widely used in medicine [80][81][82]. Due to its antibacterial properties, quaternary ammonium chitosan can be used in anti-inflammatory drugs or as a filler fiber in materials for dressing wounds [82,83].…”

Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

“…Anti-cancer, anti-virus, anti-diabetes, enzyme inhibition and anti-tuberculosis [128] Trimethyl ammonium chitosan Aspergillus flavus Biodegradable fungicide [129] Glutaraldehyde cross-linked chitosan quaternary ammonium salt film Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa Antibacterial coating [81] Compared with chitosan, quaternized chitosan has a significantly increased antibacterial activity and can be used in anti-inflammatory drugs or as a filler fiber in materials for dressing wounds [82,83]. The antibacterial mechanism of chitosan and quaternized chitosan is still inconclusive.…”

Section: Antibacterial Species Applicationmentioning

confidence: 99%

“…The antibacterial mechanism of chitosan and quaternized chitosan is still inconclusive. There are only three speculations [15,81]: (1) Chitosan and chitosan derivatives are positively charged, while bacteria are negatively charged, causing them to attract and interact with each other due to electrostatic adsorption; (2) after adsorbing bacteria, chitosan and chitosan derivatives enter the inside of bacterial cells and bind to DNA, which interferes with the transcription of bacterial DNA, thereby inhibiting the growth of bacteria; (3) chitosan and chitosan derivatives inhibit the uptake of trace elements and nutrients that are necessary for cell growth. The antibacterial mechanism of TMC is to form a complex with the cell membrane or interfere with gene expression to achieve an antibacterial effect [130].…”

Section: Antibacterial Species Applicationmentioning

confidence: 99%

See 2 more Smart Citations

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

651

326

View full text Add to dashboard Cite

Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

show abstract

Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

Section: Antibacterial Species Applicationmentioning

confidence: 99%

Section: Antibacterial Species Applicationmentioning

confidence: 99%

See 1 more Smart Citation

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

651

326

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the production of cross-linked chitosan in neutral and alkaline conditions is limited for the poor solubility of chitosan. Compared with chitosan, chitosan quaternary ammonium salt (TMCS) has higher water solubility and biological activity due to its quaternary ammonium salt group [ 17 ]. Moreover, because TMCS can dissolve under physiological conditions, it is widely used as an antimicrobial agent, flocculant, drug carrier, and tissue engineering material [ 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Zhang

Xiao-rui

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.

show abstract

“…Presently used methods for the modification of chitosan mainly include quaternization, alkylation, acetylation, carboxylation, phosphorylation, and grafting [14]. Among the derived products, quaternary ammonium chitosan salt not only maintains the unique characteristics of chitosan but also possesses better solubility and biological activities, so it plays an important role in the development of new functional chitosan derivatives [15,16]. N,N,N-trimethyl chitosan is well-known as a kind of quaternary ammonium derivative of chitosan, which has attracted an increasing number of researchers to study its properties and explore different applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl Chitosan Derivatives with Antioxidant and Antifungal Activities

Zhang

Tan

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

Chitosan is an active biopolymer, and the combination of it with other active groups can be a valuable method to improve the potential application of the resultant derivatives in food, cosmetics, packaging materials, and other industries. In this paper, a series of N,N,N-trimethyl-O-(ureidopyridinium)acetyl chitosan derivatives were synthesized. The combination of chitosan with ureidopyridinium group and quaternary ammonium group made it achieve developed water solubility and biological properties. The structures of chitosan and chitosan derivatives were confirmed by FTIR, 1H NMR spectra, and elemental analysis. The prepared chitosan derivatives were evaluated for antioxidant property by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability, hydroxyl radical scavenging ability, and superoxide radical scavenging ability. The results revealed that the synthesized chitosan derivatives exhibited improved antioxidant activity compared with chitosan. The chitosan derivatives were also investigated for antifungal activity against Phomopsis asparagus as well as Botrytis cinerea, and they showed a significant inhibitory effect on the selected phytopathogen. Meanwhile, CCK-8 assay was used to test the cytotoxicity of chitosan derivatives, and the results showed that most derivatives had low toxicity. These data suggested to develop analogs of chitosan derivatives containing ureidopyridinium group and quaternary ammonium group, which will provide a new kind of promising biomaterials having decreased cytotoxicity as well as excellent antioxidant and antimicrobial activity.

show abstract

Facile synthesis and characterization of cross-linked chitosan quaternary ammonium salt membrane for antibacterial coating of piezoelectric sensors

Cited by 49 publications

References 28 publications

Chitosan Derivatives and Their Application in Biomedicine

Chitosan Derivatives and Their Application in Biomedicine

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Synthesis and Characterization of N,N,N-trimethyl-O-(ureidopyridinium)acetyl Chitosan Derivatives with Antioxidant and Antifungal Activities

Contact Info

Product

Resources

About