Facile synthesis and fractal feature of pH-responsive poly(acrylic acid) hollow microspheres for ibuprofen delivery

Wang, Qian; Jin, Xiao; Sun, Jihong; Bai, Shi; Wu, Xia; Panezai, Hamida

doi:10.1080/00914037.2017.1393680

Cited by 6 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, nanocontainers can be used as special chambers for self-healing materials, catalysts, cancer chemotherapy medicines, metal corrosion inhibition, etc. Compared with organic carriers, including micelles, polymer nanospheres, liposomes, human ferritin, metal–organic frameworks, and 3D RNA pyramidal nanocages, which usually suffer from a poor mechanical stability, inorganic materials are more suitable for making stable and rigid carriers. In particular, nanocontainers based on silica materials are mostly desired because of their high porosity, controllable mesopore distribution, excellent chemical inertness, and mechanical properties, and hollow mesoporous silica (HMS) effectively improves the drug-loading ability, based on these advantages.…”

Section: Introductionmentioning

confidence: 99%

Hollow Mesoporous Silica Nanoparticles Decorated with Cyclodextrin for Inhibiting the Corrosion of Mg Alloys

Yang

Chen

et al. 2020

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Silica-based controlled-release materials show great potential for medical-therapy applications but have also been introduced into the area of metal anticorrosion. However, few silica-based controlled-release materials are multiresponsive based on their pseudorotaxane structure and are especially responsive to metal ions. In this work, we modified hollow mesoporous silica (HMS) with cysteine (Cys) and cyclodextrin (CD) to construct a pH/glutathione (GSH)/Mg(II)-responsive nanocontainer. The pH/GSH responsiveness takes advantage of the typical charged functional group of amino acids and the unique thiol group of Cys. Mg(II) can form complexes with CD ("cap" in pseudorotaxane), which has been proven to be correlated with the pH. Further studies have revealed that the release curve can be affected by the size of a drug or macrocycle molecule and the HMS thickness. In the end, we loaded an anticorrosion inhibitor into the carrier. The results and conclusion described in this paper can be used for the rational design of a pseudorotaxane-based delivery system and to alleviate the corrosion of Mg alloys (AZ31) in a neutral 3.5% NaCl solution.

show abstract

Section: Introductionmentioning

confidence: 99%

Hollow Mesoporous Silica Nanoparticles Decorated with Cyclodextrin for Inhibiting the Corrosion of Mg Alloys

Yang

Chen

et al. 2020

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…Among all the features that a suitable nanocarrier should have, biocompatibility and biodegradability are two more important aspects that always should be considered. − Until now, many biodegradable and biocompatible synthetic and natural polymers including polyesters, polyamides, polyethylene imines, , acrylic polymers, , polyglycerols, and polysaccharides, , have been used in the structure of smart nanocarriers. It seems that the application of natural polysaccharides in DDS is more attractive , because they are easy accessible (they are nonsynthetic) and exhibit renewability, high stability, nontoxicity, good hydrophilicity, and biodegradability in the human body. , Moreover, the unique structure of polysaccharides allows many noncovalent interactions with biological tissues, which resulted in higher cellular uptake for polysaccharide based carriers. , On the other hand, most of the natural polysaccharides contain only hydroxyl and carboxyl groups which cannot easily react with drug molecules .…”

Section: Introductionmentioning

confidence: 99%

“…7,9−11 Among all the features that a suitable nanocarrier should have, biocompatibility and biodegradability are two more important aspects that always should be considered. 12−14 Until now, many biodegradable and biocompatible synthetic and natural polymers including polyesters, 15 polyamides, 16 polyethylene imines, 17,18 acrylic polymers, 19,20 polyglycerols, 21 and polysaccharides, 22,23 have been used in the structure of smart nanocarriers. It seems that the application of natural polysaccharides in DDS is more attractive 24,25 because they are easy accessible (they are nonsynthetic) and exhibit renewability, high stability, nontoxicity, good hydrophilicity, and biodegradability in the human body.…”

Section: Introductionmentioning

confidence: 99%

Natural Salep/PEGylated Chitosan Double Layer toward a More Sustainable pH-Responsive Magnetite Nanocarrier for Targeted Delivery of DOX and Hyperthermia Application

Zohreh

Alipour

Hosseini

et al. 2019

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Two pH-responsive polysaccharide-based magnetite nanocarriers have been developed from modified salep and PEGylated chitosan decorated onto the surface of magnetite nanoparticles for active loading and targeted delivery of doxorubicin. The first nanocarrier was formed via imine bond formation and electrostatic hydrogen bonding interactions between dialdehyde salep-modified magnetite nanoparticles and DOX in a one-layered nanocarrier fashion. Subsequently, PEGylated chitosan was used as a second layer on the surface of the first nanocarrier, mainly by the same interactions, producing a double-layered polysaccharide-based nanocarrier. In vitro release studies indicated that the use of PEGylated chitosan as the second shell provides more control on the rate and amount of DOX release and makes double-layered nanocarrier more pH-sensitive. Magnetic heating capacity of double-layered nanocarrier was investigated and release profile under AMF (42 °C, magnetically induced) showed a good improvement in the time and amount of DOX release. In vitro MTT assays depicted that the DOX-loaded double-layered nanocarrier produces a large cytotoxic response to HeLa cells, which is comparable with free DOX in higher concentration. DOX-free double-layered nanocarrier also exhibited low cytotoxicity against normal cells, an indication of their excellent biocompatibility. Application of AMF also showed a large effect on the cytotoxicity of the nanocarrier rather than without AMF condition. Investigation on cellular uptake of nanocarrier revealed the high targeting ability of nanocarrier toward HeLa cells, especially in the presence of AMF. Blood compatibility investigations indicated that hemolysis of RBCs and coagulation times fall into the normal range for blood in the presence of DOX-free and DOX-loaded double-layered nanocarrier.

show abstract

Sustained‐release ibuprofen prodrug particle: Emulsifier and initiator regulate the diameter and distribution

Wang

Zhang

Qian

et al. 2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

Polymers have played a vital part in the development of drug delivery systems (DDS). For DDS, having a controllable diameter and distribution are conducive to reproducibility of drug release behavior and efficacy. In this work, an ibuprofen prodrug (Ibu@PMMA) was synthesized by methyl methacrylate (MMA), ibuprofen monomer (Ibu@HEMA), and ethylene glycol dimethacrylate (EGDMA) via emulsion polymerization. The Ibu@PMMA exhibits spherical shapes, and its structural properties were characterized by NMR, FTIR, and SEM techniques. In addition, the hydrodynamic diameter and polydispersity index (PDI) of Ibu@PMMA were reduced by increasing the proportion of emulsifier. Meanwhile, by increasing the amount of initiator, the hydrodynamic diameter and PDI of Ibu@PMMA were decreased. Moreover, Ibu@PMMA exhibits good sustainedrelease ability in vitro, which could be used as a potential delivery system for antiinflammatory agents.

show abstract

Facile synthesis and fractal feature of pH-responsive poly(acrylic acid) hollow microspheres for ibuprofen delivery

Cited by 6 publications

References 46 publications

Hollow Mesoporous Silica Nanoparticles Decorated with Cyclodextrin for Inhibiting the Corrosion of Mg Alloys

Hollow Mesoporous Silica Nanoparticles Decorated with Cyclodextrin for Inhibiting the Corrosion of Mg Alloys

Natural Salep/PEGylated Chitosan Double Layer toward a More Sustainable pH-Responsive Magnetite Nanocarrier for Targeted Delivery of DOX and Hyperthermia Application

Sustained‐release ibuprofen prodrug particle: Emulsifier and initiator regulate the diameter and distribution

Contact Info

Product

Resources

About