Facile synthesis of a hydrazone-based zinc(<scp>ii</scp>) complex for ferroptosis-augmented sonodynamic therapy

Li, Dan; Fan, Minghui; Wang, Haobing; Zhu, Yongjie; Yu, Bole; Zhang, Pingyu; Huang, Huaiyi

doi:10.1039/d4sc02102a

Cited by 2 publications

References 53 publications

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Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies

Das

2024

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Transition metal complex‐loaded nanosystems (TMCNs) represent a cutting‐edge platform for stimuli (light, ultrasound)‐responsive cancer therapies. These nanosystems, incorporating metals such as manganese(II), zinc(II), ruthenium(II), rhenium(I), iridium(III), and platinum(IV), significantly enhance the efficacy of light‐activated therapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), as well as ultrasound‐activated treatments like sonodynamic therapy (SDT). TMCNs based on ruthenium(II), rhenium(I), and iridium(III) improve PDT, while manganese(II) and iridium(III) demonstrate exceptional sonosensitizing properties. In PTT, ruthenium(II) and iridium(III)‐based TMCNs efficiently absorb light and generate heat. Emerging synergistic approaches that combine SDT, PTT, PDT, chemotherapy, and immunotherapy are demonstrated to be powerful strategies for precision cancer treatment. Zinc(II), ruthenium(II), iridium(III), and platinum(IV)‐based TMCNs play a critical role in optimizing these therapies, enhancing tumor targeting, and reducing side effects. Furthermore, TMCNs can amplify immunotherapy by inducing immunogenic cell death, thus strengthening the immune response. These advances address key challenges such as tumor hypoxia and therapeutic resistance, opening new possibilities for innovative photosensitizer‐based cancer treatments. This review highlights the latest progress in TMCNs design and applications, demonstrating their potential to revolutionize stimuli‐responsive cancer therapies.

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Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies

Das

2024

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Novel Cu-II Complexes of 2-Hydroxy 4-Methoxy Benzylidene 2-Hydroxy Benzhydrazide: Synthesis, Spectral Characterization, Thermal, Antimicrobial, Antioxidant and Catalytic activity Study

Korane,

Bhosale,

Jadhav

2024

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The novel hydrazone ligand 2-hydroxy 4-methoxy benzylidene 2-hydroxy benzhydrazide [HL] was prepared by condensing 2-hydroxy benzhydrazide and 2-hydroxy 4-methoxy benzaldehyde in methanol solvent. The Cu-II complexes [Cu(HL)(NO3)].1/3H2O (1a), [{Cu (HL)}2 (μ-SO4)].12/3H2O(2a), [Cu(HL)(H2O) Cl](3a) were synthesized by refluxing Cu-II salts CuNO3.3H2O CuSO4.5H2O and CuCl2.2H2O with methanol solution of [HL] and characterized by spectral techniques (FT-IR,1H-NMR,13C–NMR,UV-Visible, PXRD study).The complexes are further characterized by thermo gravimetric(TG)analysis, molar conductivity, elemental analysis and magnetic susceptibility measurement study. FT-IR spectra provides valuable information about different coordination sites. UV-Visible spectroscopy reflect LMCT bands from 242718- 261780 cm-1 and d-d bands in the range of 143884-156250 cm-1 in addition to n-π*and π -π*transition in all complexes. Square planar to square pyramidal geometry was proposed for all complexes as illustrated in magnetic, electronic and spectroscopic data. X-ray powder diffraction analysis reveals crystalline nature for all complexes. The experimental results of TGA analysis are in good agreement with spectroscopic data of complexes. A comparison of spectroscopic and physicochemical data are very useful in creating correct assignments and understanding of structure of complex. The ligand act as tribasic tridentate chelating through the phenolate oxygen, azomethine nitrogen and oxygen of enolate donar functionality with copper-II ion. The antibacterial potential of synthesized complex catalysts was evaluated against human pathogenic bacteria such as Bacillus subtilties, Bacillus cereus, Escherichia coli, Pseudomonas velgaris,and Staphylococcus aureus etc. Also, the Cu (II) complexes demonstrate significant antioxidant activity. The catalytic performance in alcohol oxidation using hydrogen peroxide as a green oxidant is also investigated.

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Facile synthesis of a hydrazone-based zinc(ii) complex for ferroptosis-augmented sonodynamic therapy

Abstract: Sonodynamic therapy (SDT), as a novel non-invasive cancer treatment modality derived from photodynamic therapy (PDT), has drawn much attention due to its unique advantages for the treatment of deep tumors....

Cited by 2 publications

References 53 publications

Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies

Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies

Novel Cu-II Complexes of 2-Hydroxy 4-Methoxy Benzylidene 2-Hydroxy Benzhydrazide: Synthesis, Spectral Characterization, Thermal, Antimicrobial, Antioxidant and Catalytic activity Study

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