Facile synthesis of a hyperbranched polymer prodrug as unimolecular micelles for overcoming multidrug resistance

Abstract

Unimolecular micelles have attracted more interests as drug delivery systems (DDSs) owing to their superior stability. Here, hyperbranched polymer prodrug (HBPP) was designed with high drug content of 57.6% as...

GSH-triggered disintegrable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific chemotherapy

“…2a). 12,21 The inset in Fig. 2a reveals HBPP-DOX-3 micelles in PBS with a strong Tyndall effect, also confirming their excellent dispersibility.…”

“…2c), also indicating the formation of unimolecular micelles with superior stability. 12,21 The supernatant of the GSH-triggered disintegrable unimolecular micelles after treatment with pH 7.4 PBS + 10% BSA for 5 days was colorless and showed no absorbance of DOX (Fig. S12†).…”

“…There are two main approaches to fabricating a hyperbranched polymer prodrug as prodrug unimolecular micelles: conjugating drugs onto the reactive end groups in the hyperbranched or star-like polymers [8][9][10][11] and polymerization of the prodrug monomers. [12][13][14][15] Comparatively, the latter shows more application prospects, owing to its easy operation and high drug content.…”

Progress in synthesis, modification, characterization and applications of hyperbranched polyphosphate polyesters

“…[ 52 ] Copyright 2014, Polym Degrad Stabil. [ 63 ] Copyright 2022, Polym Chem. [ 70 ] Copyright 2010, Langmuir.…”

“…Figure 6 is the synthetic routes of CPMs with different pendant groups. The design of hyperbranched polymer can benefit from their unique core-shell structure, and hyperbranched multi-arm copolymers have been prepared as unimolecular micelles to overcome the disadvantages of classical micelles [ 63 , 64 ]. Furthermore, the HPPs would possess good biocompatibility, biodegradability, and structural similarity to nucleic and teichoic acids [ 65 , 66 ].…”