Facile synthesis of Au@Ag–hemin decorated reduced graphene oxide sheets: a novel peroxidase mimetic for ultrasensitive colorimetric detection of hydrogen peroxide and glucose

Kumar, Sanjay; Bhushan, Pulak; Bhattacharya, Shantanu

doi:10.1039/c7ra06973a

Cited by 52 publications

(25 citation statements)

References 40 publications

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“…Since H 2 O 2 is ap roduct of glucose oxidized by O 2 in the presence of glucose oxidase (GOx), the CNM-catalyzed reaction can be readily adapted to detect glucose (Table S2). [35,[39][40][41]44,47,50,57,61,64,67,68,75,79,80,82,91,95,96,99,111,114,120,143,149,150,154,157,170] According to the above working principle, afast, simple,sensitive,and selective colorimetric method for glucose detection with alimit of detection as low as 1 mm has been presented ( Figure 4). [35] Theprotocol is reliable enough and has been used for analysis of glucose in actual samples, such as diluted blood and commercial fruit juices.…”

Section: Biosensors For Biomolecules That Canproduce H 2 Omentioning

confidence: 99%

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Carbon Nanozymes: Enzymatic Properties, Catalytic Mechanism, and Applications

et al. 2018

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Nanozymes have advantages over natural enzymes, such as facile production on large scale, long storage time, low costs, and high stability in harsh environments. Carbon nanomaterials (CNMs), including fullerenes, carbon nanotubes, graphene, carbon quantum dots, and graphene quantum dots, have become a star family in materials science. As a new class of nanozymes, the catalytic activity of CNMs and their hybrids has been extensively reported. In this Minireview, recent progress of CNMs based artificial enzymes, focusing on those with peroxidase-like activity, has been summarized. The enzymatic properties, catalytic mechanisms, and novel applications of CNM nanozymes in sensing, therapy, and environmental engineering are discussed in detail. Additionally, we also highlight the remaining challenges and unsolved problems. With the fast development of bionanotechnology, the unique enzymatic properties and advantages of CNM nanozymes have received much attention and will continue to be an active and challenging field for the years to come.

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Section: Biosensors For Biomolecules That Canproduce H 2 Omentioning

confidence: 99%

“…144,145,149,154,157,170] Them ain results of CNM-based artificial peroxidases used for detection of H 2 O 2 were summarized in…”

mentioning

confidence: 99%

Carbon Nanozymes: Enzymatic Properties, Catalytic Mechanism, and Applications

et al. 2018

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“…Except for above‐mentioned nanocomposites, other novel nanocomposites are also designed to possess enhanced peroxidase‐like activity. Those nanocomposites including TiO 2 @CeO x core–shell nanoparticles, MnSe loaded g‐C 3 N 4 nanocomposite, Au@Ag–hemin modified reduced graphene oxide sheets, Cu–Ag bimetallic nanoparticles decorated reduced graphene oxide sheets, graphene supported Au–Pd bimetallic nanoparticles, graphene quantum dots–copper oxide nanocomposites (GQDs/CuO), TiO 2 ‐encapsulated Au (Au@TiO 2 ) yolk–shell nanostructure, CoSe 2 /reduced graphene oxide (CoSe 2 /rGO) hybrid, and montmorillonite‐supported ZnS, and CuS and Ag 2 S nanocomposites. The enhanced peroxidase‐like activity of those nanocomposites are attributed to synergistic interaction of two components as well.…”

Section: Peroxidase‐like Activity Of Nanomaterialsmentioning

confidence: 99%

“…Other nanocomposites with enhanced peroxidase‐like activity for colorimetric biosensing of glucose were reported by many groups as well. Such as, TiO 2 @CeO x core–shell nanoparticles, MnSe loaded g‐C 3 N 4 nanocomposite, Au@Ag–hemin decorated reduced graphene oxide sheets, Cu–Ag bimetallic nanoparticles decorated reduced graphene oxide sheets, graphene quantum dots–copper oxide nanocomposites (GQDs/CuO), TiO 2 ‐encapsulated Au (Au@TiO 2 ) yolk–shell nanostructure, and CoSe 2 /reduced graphene oxide (CoSe 2 /rGO) hybrid (see Table ). Those enhanced peroxidase‐like activity of nanocomposites fabricated colorimetric glucose biosensors usually exhibits low detection limit.…”

Section: Glucose Biosensormentioning

confidence: 99%

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Liu

Huang

Qin

et al. 2019

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Diabetes is a dominating health issue with 425 million people suffering from the disease worldwide and 4 million deaths each year. To avoid further complications, the diabetic patient blood glucose level should be strictly monitored despite there being no cure for diabetes. Colorimetric biosensing has attracted significant attention because of its low cost, simplicity, and practicality. Recently, some nanomaterials have been found that possess unexpected peroxidase‐like activity, and great advances have been made in fabricating colorimetric glucose biosensors based on the peroxidase‐like activity of these nanomaterials using glucose oxidase. Compared with natural horseradish peroxidase, the nanomaterials exhibit flexibility in structure design and composition, and have easy separation and storage, high stability, simple preparation, and tunable catalytic activity. To highlight the significant progress in the field of nanomaterial‐based peroxidase‐like activity, this work discusses the various smart nanomaterials that mimic horseradish peroxidase and its mechanism and development history, and the applications in colorimetric glucose biosensors. Different approaches for tunable peroxidase‐like activity of nanomaterials are summarized, such as size, morphology, and shape; surface modification and coating; and metal doping and alloy. Finally, the conclusion and challenges facing peroxidase‐like activity of nanomaterials and future directions are discussed.

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“…Nanozymes refer to nanomaterials with enzyme mimicking activities . It has become a hot topic in recent years due to the facile synthesis, tunable catalytic activities, high stability, low cost, and ease of treatment . Nanozymes are promising alternatives for natural enzymes in various applications.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanozyme Research

2018

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inflammatory response to combat infections and can also react with many important biomolecules including proteins, lipids, and nucleic acid polymers (RNA and DNA). [7] Low dosage of ROS plays important roles in signal transduction, cell proliferation/migration/differentiation, and body defense against pathogen invasion. However, abnormally elevated ROS level can destroy redox homeostasis and cause oxidative stress and serious damage of structure and function of macromolecules in the cell. Research during the last decade has shown that oxidative stress could lead to diseases such as chronic inflammation and eventually diabetes, cancer, as well as cardiovascular, neurological, and pulmonary diseases. [8] Enzyme systems (e.g., superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase) are responsible for protecting cells from the detrimental effects of ROS by modulating the intracellular ROS level.Nanozyme can also modulate the ROS level in cells (Figure 2). [9] The ROS scavenging abilities of nanozymes largely originate from the SOD mimicking activities, which convert superoxide into H 2 O 2 and subsequently to O 2 and H 2 O, and thus reduce the intracellular ROS level and enhance cell viability. The generation of ROS originates from their peroxidases (POD) activities, which convert H 2 O 2 to OH· radicals, and oxidase activities, which convert O 2 to H 2 O 2 . Outside the cell, ROS can react with biologically active molecules (such as glucose, dopamine, glutathione, and adenosine triphosphate), organic compound (such as phenol and dyes), and pollutants from aqueous solutions. Thus the nanozymes could play important roles in in vitro test and environmental protection. [10] Earlier reports on nanozymes mainly focused on the aspect of experimental study and rarely focused on the theoretical work and mechanism clarification. In this progress report, we first introduce various nanozymes and highlight recent experimental development of new nanozymes that have been investigated to mimic various enzymes. Then we review their applications in various fields including biosensing, bioimaging, therapeutics, and environmental protection. At last, we summarize the catalytic mechanisms and address the challenges of experimental and computational research in this field. The Structure of NanozymesIssues of material design for high catalytical activity, selectivity, and durability are recently accentuated. Among them As a new generation of artificial enzymes, nanozymes have the advantages of high catalytic activity, good stability, low cost, and other unique properties of nanomaterials. Due to their wide range of potential applications, they have become an emerging field bridging nanotechnology and biology, attracting researchers in various fields to design and synthesize highly catalytically active nanozymes. However, the thorough understanding of experimental phenomena and the mechanisms beneath practical applications of nanozymes limits their rapid development. Herein, the progress of experimental and computational...

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Facile synthesis of Au@Ag–hemin decorated reduced graphene oxide sheets: a novel peroxidase mimetic for ultrasensitive colorimetric detection of hydrogen peroxide and glucose

Abstract: Hemin–Au@Ag–graphene oxide, a quaternary nanocomposite employed as an efficient peroxidase mimetic for ultrasensitive detection of hydrogen peroxide and glucose.

Cited by 52 publications

References 40 publications

Carbon Nanozymes: Enzymatic Properties, Catalytic Mechanism, and Applications

Carbon Nanozymes: Enzymatic Properties, Catalytic Mechanism, and Applications

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Recent Advances in Nanozyme Research

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