Facile synthesis of bentonite/biopolymer composites as low-cost carriers for 5-fluorouracil drug; equilibrium studies and pharmacokinetic behavior

Abukhadra, Mostafa R.; Refay, Nermen M.; El-Sherbeeny, Ahmed M.; Mostafa, Almetwally M.; El-Meligy, Mohammed A.

doi:10.1016/j.ijbiomac.2019.09.057

Cited by 52 publications

(103 citation statements)

References 56 publications

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“… 1 , 8 This is related to its low selectivity, limited solubility, high diffusion rate, and toxic properties of 5-Fu overdosage. 7 , 9 This resulted in an increment in the required dosage during the treatment periods which might cause damage to the uninfected cells. Additionally, such high dosages exert toxic effects on the gastrointestinal tract, nervous system, hematological system, cardiac system, and cause dermatological reactions.…”

Section: Introductionmentioning

confidence: 99%

“… 12 , 13 Besides the previous requirements, the selection of the appropriate carrier depends mainly on the fabrication cost, biocompatibility, availability, loading capacity, release rate, and cytotoxicity of the material. 7 , 14 , 15 Therefore, numerous materials were introduced as effective carriers for 5-Fu drugs including natural zeolite; 4 , 16 biopolymers such as cellulose, alginate, and chitosan; 5 , 15 montmorillonite; 9 kaolinite; 8 and layered double hydroxide. 17 …”

Section: Introductionmentioning

confidence: 99%

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Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

et al. 2022

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Herein, natural zeolite (clinoptilolite) was functionalized by Na + ions (G.Na + /Clino) utilizing a green tea extract prepared by a green production method as a potential carrier for the 5-fluorouracil (5-Fu) drug with enhanced physicochemical behaviors. The G.Na + /Clino-modified product showed enhanced surface area (312 m 2 /g) and ion-exchange capacity (387 mequiv/100 g). The loading studies reflect high and controlled loading properties of G.Na + /Clino with an actual loading capacity of 291 and 462 mg/g, respectively. The loading reactions of 5-Fu into G.Na + /Clino were of pseudo-second-order kinetics and exhibited Langmuir isotherm properties. This suggested a monolayer and homogeneous loading process by chemical complexation and ion-exchange mechanisms with a Gaussian energy value of 10.47 kJ/mol. Additionally, these reactions were of endothermic and spontaneous nature based on the determined thermodynamic parameters. The release studies demonstrated the 5-Fu release profile for about 150 h at pH 1.2 and for 80 h at pH 7.4. The release reactions had non-Fickian transport properties and were controlled by both erosion and diffusion mechanisms, considering the release kinetic findings and the values of the diffusion exponent (0.42 at pH 1.2 and 0.37 at pH 7.4). The composite showed remarkable biocompatibility based on the measured cell viability and a cytotoxic effect on normal colorectal cells (CCD-18Co). Additionally, the application of G.Na + /Clino as an inorganic carrier for the 5-Fu drug prompted the cytotoxic effect of the drug on colon cancer cell treatment (HCT-116).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

et al. 2022

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“…Such behavior was because of the continuous occupation of the essential active loading sites in the EXK/CF composite with OL molecules with time, making the loading process limited by the remaining sites until reaching the full occupation. 8 …”

Section: Resultsmentioning

confidence: 99%

“…Generally, this model suggests controlling the releasing behavior by the erosion mechanism. 8 The Korsmeyer–Peppas kinetic model was categorized as the best kinetic model that can explain the release profiles of polymer-based drug carriers either by the diffusion mechanism or by the erosion mechanism and sometimes a combination of them. 20 …”

Section: Resultsmentioning

confidence: 99%

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

et al. 2020

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Kaolinite layers were exfoliated as single sheets and admixed with cellulose fibers, forming an advanced exfoliated kaolinite/cellulose fiber (EXK/CF) composite, which was characterized as a promising carrier for the oxaliplatin (OL) drug to induce safety as well as the therapeutic effect. The EXK/CF composite exhibited promising loading capacity and achieved an experimental value of 670 mg/g and an expected theoretical value of 704.4 mg/g. The loading behavior of OL using the EXK/CF composite followed the pseudo-first-order kinetic model and the Langmuir equilibrium model, achieving an adsorption energy of 7.7 kJ/mol. This suggested physisorption and homogeneous loading behavior of the OL molecules in a monolayer form. The release profile of OL from EXK/CF continued for about 100 h with maximum release percentages of 86.4 and 95.2% in the phosphate and acetate buffers, respectively. The determined diffusion exponent from the Korsmeyer–Peppas kinetic model suggested non-Fickian transport behavior of the OL molecules and releasing behavior controlled by erosion as well as diffusion mechanisms. Regarding the cytotoxic effect, the EXK/CF composite has a high safety impact on the normal colorectal cells (CCD-18Co) and higher toxic impacts on the colorectal cancer cell (HCT116) than the free oxaliplatin drug.

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“…Bentonite (Bt) is an important natural clay material; widely used in many industries, which is made of hydrous aluminosilicates, consisting mostly of montmorillonite, and contains fewer amounts of other clay minerals [6,7]. Bt appears as a promising support material due to its mechanical strength and chemical stability, low cost, and availability [8].…”

Section: Introductionmentioning

confidence: 99%

Characterization of surface properties of chitosan/bentonite composites beads by inverse gas chromatography

Bensalem

Hamdi

Confetto

et al. 2021

International Journal of Biological Macromolecules

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Chitosan/bentonite (CSBt) composites beads were prepared by dropwise of a solution containing chitosan and bentonite to an alkaline NaOH solution. Fourier Transform Infrared Spectroscopy, X-ray diffraction analysis, Xray photoelectron spectroscopy, XPS and Brunauer-Emmett-Teller BET analysis have been used to provide new insights on the composition and morphology of CSBt composites beads surface. In this study, inverse gas chromatography (IGC) was implemented to characterize physico-chemical properties of CSBt composites surface. IGC at infinite dilution (IGC-ID) was used to understand the effect of CS on dispersive component of the surface energy of the bentonite. The increasing amount of CS leads to significantly decrease of Bt γ s d emphasizing the Bt coating with CS. The IGC at finite concentration (IGC-FC) was also implemented allowing us to reach several parameters such as: specific surface area with organic probes and the distribution functions of the adsorption energy sites on the solid surface. In this case, the most significant decreases were observed in the specific surface area obtained with the octane and isopropanol probes. The distribution function of the adsorption energy sites obtained with isopropanol revealed the decrease in the number of the high energy sites with increase of CS/Bt mass ratio.

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Facile synthesis of bentonite/biopolymer composites as low-cost carriers for 5-fluorouracil drug; equilibrium studies and pharmacokinetic behavior

Cited by 52 publications

References 56 publications

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

Characterization of surface properties of chitosan/bentonite composites beads by inverse gas chromatography

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Facile synthesis of bentonite/biopolymer composites as low-cost carriers for 5-fluorouracil drug; equilibrium studies and pharmacokinetic behavior

Cited by 52 publications

References 56 publications

Insight into the Loading Properties of Na+ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Insight into the Loading Properties of Na+ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

Characterization of surface properties of chitosan/bentonite composites beads by inverse gas chromatography

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Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity