Facile synthesis of bifunctional silica-coated core–shell Y2O3:Eu3+,Co2+ composite particles for biomedical applications

Atabaev, Timur Sh.; Jin, Oh Seong; Lee, Jong Ho; Han, Dong‐Wook; Vu, Hong Ha Thi; Hwang, Yoon Hwae; Kim, Hyung Kook

doi:10.1039/c2ra21332j

Cited by 38 publications

(14 citation statements)

References 26 publications

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“…All samples were measured under identical conditions so that the emission ratio could be compared. Figure 2 shows the PL emission spectrum revealed several main groups of emission lines, which were assigned to the 5 D 1 → 7 F 1 and 5 D 0 → 7 F j (where j = 0, 1, 2, 3) transitions within the Eu 3+ [12,13,14]. Partial replacement of Y 3+ with Gd 3+ in the host matrix allows easier charge transfer from Gd 3+ to Eu 3+ [15].…”

Section: Resultsmentioning

confidence: 99%

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Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

et al. 2017

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Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y2O3 nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL). The cytotoxicity test showed that the prepared lanthanide-doped Y2O3 nanoprobes have good biocompatibility. The obvious contrast enhancement in the T1-weighted MR images suggested that these nanoprobes can be used as a positive contrast agent in MRI. In addition, the clear fluorescence images of the L-929 cells incubated with the nanoprobes highlight their potential for optical imaging. Overall, these results suggest that prepared lanthanide-doped Y2O3 nanoprobes can be used for simultaneous optical and MR imaging.

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Section: Resultsmentioning

confidence: 99%

“…For example, recent studies have suggested that a homogeneous yttria-lanthanides solid mixture can be obtained using the homogeneous urea precipitation method [11,12]. In addition, yttria-based nanostructures can potentially be used for optical biomaging purposes [13,14]. …”

Section: Introductionmentioning

confidence: 99%

Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

et al. 2017

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“…After the membrane is wrapped by NPs, some NPs are invaginated in the vesicle, which looks like agglomerates [36]. Although the further detailed study for the cellular uptake mechanism was not examined here, previous seminal studies have shown that larger NPs (100–200 nm) would be incorporated into cells more readily by endocytosis than smaller ones (~10 nm), which are generally taken up by cells via pinocytosis [37,38]. Smaller APTMS-coated MNPs are considered to easily permeate the cell membrane by pinocytosis.…”

Section: Resultsmentioning

confidence: 99%

Difference between Toxicities of Iron Oxide Magnetic Nanoparticles with Various Surface-Functional Groups against Human Normal Fibroblasts and Fibrosarcoma Cells

et al. 2013

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Recently, many nanomedical studies have been focused on magnetic nanoparticles (MNPs) because MNPs possess attractive properties for potential uses in imaging, drug delivery, and theranostics. MNPs must have optimized size as well as functionalized surface for such applications. However, careful cytotoxicity and genotoxicity assessments to ensure the biocompatibility and biosafety of MNPs are essential. In this study, Fe3O4 MNPs of different sizes (approximately 10 and 100–150 nm) were prepared with different functional groups, hydroxyl (–OH) and amine (–NH2) groups, by coating their surfaces with tetraethyl orthosilicate (TEOS), 3-aminopropyltrimethoxysilane (APTMS) or TEOS/APTMS. Differential cellular responses to those surface-functionalized MNPs were investigated in normal fibroblasts vs. fibrosarcoma cells. Following the characterization of MNP properties according to size, surface charge and functional groups, cellular responses to MNPs in normal fibroblasts and fibrosarcoma cells were determined by quantifying metabolic activity, membrane integrity, and DNA stability. While all MNPs induced just about 5% or less cytotoxicity and genotoxicity in fibrosarcoma cells at lower than 500 μg/mL, APTMS-coated MNPs resulted in greater than 10% toxicity against normal cells. Particularly, the genotoxicity of MNPs was dependent on their dose, size and surface charge, showing that positively charged (APTMS- or TEOS/APTMS-coated) MNPs induced appreciable DNA aberrations irrespective of cell type. Resultantly, smaller and positively charged (APTMS-coated) MNPs led to more severe toxicity in normal cells than their cancer counterparts. Although it was difficult to fully differentiate cellular responses to various MNPs between normal fibroblasts and their cancer counterparts, normal cells were shown to be more vulnerable to internalized MNPs than cancer cells. Our results suggest that functional groups and sizes of MNPs are critical determinants of degrees of cytotoxicity and genotoxicity, and potential mechanisms of toxicity.

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“…The number of viable cells was directly proportional to the metabolic reaction products obtained in the CCK-8 assay [33, 34]. Briefly, a concentration of 1 × 10 4 cells/ml was seeded on each mat, and incubated for 4 h (cell attachment) or 1, 3, 5 and 7 days (proliferation) at 37°C.…”

Section: Methodsmentioning

confidence: 99%

RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering

Shin¹,

Kim²,

Kim³

et al. 2017

Regenerative Biomaterials

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In recent years, much research has been suggested and examined for the development of tissue engineering scaffolds to promote cellular behaviors. In our study, RGD peptide and graphene oxide (GO) co-functionalized poly(lactide-co-glycolide, PLGA) (RGD-GO-PLGA) nanofiber mats were fabricated via electrospinning, and their physicochemical and thermal properties were characterized to explore their potential as biofunctional scaffolds for vascular tissue engineering. Scanning electron microscopy images revealed that the RGD-GO-PLGA nanofiber mats were readily fabricated and composed of random-oriented electrospun nanofibers with average diameter of 558 nm. The successful co-functionalization of RGD peptide and GO into the PLGA nanofibers was confirmed by Fourier-transform infrared spectroscopic analysis. Moreover, the surface hydrophilicity of the nanofiber mats was markedly increased by co-functionalizing with RGD peptide and GO. It was found that the mats were thermally stable under the cell culture condition. Furthermore, the initial attachment and proliferation of primarily cultured vascular smooth muscle cells (VSMCs) on the RGD-GO-PLGA nanofiber mats were evaluated. It was revealed that the RGD-GO-PLGA nanofiber mats can effectively promote the growth of VSMCs. In conclusion, our findings suggest that the RGD-GO-PLGA nanofiber mats can be promising candidates for tissue engineering scaffolds effective for the regeneration of vascular smooth muscle.

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Facile synthesis of bifunctional silica-coated core–shell Y2O3:Eu3+,Co2+ composite particles for biomedical applications

Cited by 38 publications

References 26 publications

Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

Difference between Toxicities of Iron Oxide Magnetic Nanoparticles with Various Surface-Functional Groups against Human Normal Fibroblasts and Fibrosarcoma Cells

RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering

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