Facile Synthesis of Biocompatible Amine Oxide Grafted Fullerene and Its Antioxidant Performances without Metal Loading

Xia, Yuxuan; Ma, Jiaxin; Zheng, Jiangxia; Lü, Zhigang; Zhang, Qiong; Li, Baowei; Chen, Siyu; Li, Dongmei; Zhang, Qiang; Hong, Liu; Zhao, Bingtian; Yang, Cheng

doi:10.1134/s1070363222110238

Russ J Gen Chem

2022

DOI: 10.1134/s1070363222110238

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Facile Synthesis of Biocompatible Amine Oxide Grafted Fullerene and Its Antioxidant Performances without Metal Loading

Yuxuan Xia

Jiaxin Ma

Jiangxia Zheng

et al.

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2024

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Fullerene Nanorings as Nitric Oxide Radical Scavengers for Ultraviolet-Induced Cellular Injury

Zhang,

Hong

et al. 2024

ACS Appl. Nano Mater.

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Nitric oxide radical (NO • ) induced by UV irradiation would exacerbate cellular damage and apoptosis. Though fullerenes are known as excellent radical scavengers, severe aggregation and poor bioavailability often decrease their antioxidant capability in real bioapplications. Herein, a simple but effective method is introduced for the synthesis of a novel hollow fullerene nanostructure (f ullerene nanoring, FNR). C 60 aggregations produced in m-xylene/isopropyl alcohol (IPA) binary solvents by liquid− liquid interface precipitation strategy are chemically etched by the addition of ethylenediamine (EDA), while aminofullerenes subsequently nucleate at the interface of short-lived EDA-IPA droplets. Careful control of the nucleation kinetics via fine-tuning of the xylene/IPA ratio proved critical for the successful formation of ring-shaped FNR. Such hydrophilic and lowcytotoxic nanostructures possess surprisingly outstanding scavenging performance toward NO • (IC 50 = 80 μg/mL). Prominent cytoprotection of FNR against UV-induced DNA oxidation and cellular injury is further confirmed by laser confocal microscopy and flow cytometry. Our results may benefit the upgradation of nanocarbon materials for bioapplications.

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Fullerene Nanorings as Nitric Oxide Radical Scavengers for Ultraviolet-Induced Cellular Injury

Zhang,

Hong

et al. 2024

ACS Appl. Nano Mater.

Self Cite

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show abstract

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Facile Synthesis of Biocompatible Amine Oxide Grafted Fullerene and Its Antioxidant Performances without Metal Loading

Cited by 1 publication

References 57 publications

Fullerene Nanorings as Nitric Oxide Radical Scavengers for Ultraviolet-Induced Cellular Injury

Fullerene Nanorings as Nitric Oxide Radical Scavengers for Ultraviolet-Induced Cellular Injury

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