Facile synthesis of bis(indol-3-yl)methane derivatives catalyzed by carboxylic acid functionalized ionic liquid at room temperature: Investigation of photophysical properties, DFT calculations and molecular docking with bovine serum albumin

Pasuparthy, Sai Deepak; Maiti, Barnali

doi:10.1016/j.tet.2024.133845

Tetrahedron

2024

DOI: 10.1016/j.tet.2024.133845

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Facile synthesis of bis(indol-3-yl)methane derivatives catalyzed by carboxylic acid functionalized ionic liquid at room temperature: Investigation of photophysical properties, DFT calculations and molecular docking with bovine serum albumin

Sai Deepak Pasuparthy,

Barnali Maiti

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Cited by 3 publications

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Brønsted Acid Saponin Combined Catalyst (BASapC) for the Synthesis of Diverse 1,1‐Dihomoarylmethane Scaffolds in Aqueous Solution

Nirmale,

Patil,

Kumbhar

et al. 2024

ChemistrySelect

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The present study describes the synthesis of various bioactive compounds, including bis‐coumarins, bis‐lawsones, bis‐dimedones, and bis‐indolylmethanes, using a novel catalytic system called “Brønsted acid saponin combined catalyst” (BASapC). The BASapC was formed by combining p‐toluenesulfonic acid (PTSA) and saponin in an aqueous medium. The prepared BASapC proved to be effective in facilitating cascade‐type Knoevenagel–Michael addition reactions between various aromatic aldehydes with 4‐hydroxycoumarin, lawsone, dimedone, or indole at 80 °C. In the BASapC system, PTSA acted as a powerful Brønsted acid, activating reactants, whereas saponin served as a natural surfactant, enhancing the solubility of organic compounds in water. This catalytic approach established a straightforwardness and robustness of diversity‐oriented synthesis (DoS), delivering the desired products with good to excellent yields. Additionally, the BASapC exhibited recyclability for at least four cycles without significant loss of activity.

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Brønsted Acid Saponin Combined Catalyst (BASapC) for the Synthesis of Diverse 1,1‐Dihomoarylmethane Scaffolds in Aqueous Solution

Nirmale,

Patil,

Kumbhar

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

Synthesis of dimeric indoles from Friedel–Crafts reaction of indoles with ketones catalysed by a Brønsted acid ionic liquid and their interactions with BSA and DNA

Pasuparthy,

Somkuwar,

Kali

et al. 2024

New J. Chem.

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Transition metal-free efficient synthesis of bis(indolyl)propynes (BIPs)

Chaturvedi,

Sharma,

Nafla CM

et al. 2024

Org. Biomol. Chem.

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Facile synthesis of bis(indol-3-yl)methane derivatives catalyzed by carboxylic acid functionalized ionic liquid at room temperature: Investigation of photophysical properties, DFT calculations and molecular docking with bovine serum albumin

Cited by 3 publications

References 65 publications

Brønsted Acid Saponin Combined Catalyst (BASapC) for the Synthesis of Diverse 1,1‐Dihomoarylmethane Scaffolds in Aqueous Solution

Brønsted Acid Saponin Combined Catalyst (BASapC) for the Synthesis of Diverse 1,1‐Dihomoarylmethane Scaffolds in Aqueous Solution

Synthesis of dimeric indoles from Friedel–Crafts reaction of indoles with ketones catalysed by a Brønsted acid ionic liquid and their interactions with BSA and DNA

Transition metal-free efficient synthesis of bis(indolyl)propynes (BIPs)

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