Facile synthesis of curcumin-containing poly(amidoamine) dendrimers as pH-responsive delivery system for osteoporosis treatment

Yang, Xiaowei; Kuang, Zhihui; Yang, Xiaoguang; Hu, Xin; Luo, Pei; Lai, Qi; Zhang, Bin; Zhang, Xiaoyong; Wei, Yen

doi:10.1016/j.colsurfb.2022.113029

Cited by 8 publications

(3 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 35 Research on the use of curcumin for osteoporosis prevention or treatment has been conducted nationally and internationally. 36 , 37 , 38 For example, Heo’s study showed that cyclodextrin/curcumin complexes significantly improved bone density and prevented bone loss in an OVX mouse model. 39 Chen et al.…”

Section: Discussionmentioning

confidence: 99%

Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development

Wang,

Xie,

et al. 2024

iScience

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development

Wang,

Xie,

et al. 2024

iScience

View full text Add to dashboard Cite

“…Yang studied the use of hexachlorocyclotriphosphazene (HCCP) as a linker to couple CUR and PAMAM to make nanoparticles, and the loading capacity of CUR could reach 27.2%. This nanoparticle effectively inhibited the differentiation of osteoclasts in a dose-dependent manner and promoted osteogenesis [ 120 ].…”

Section: Polyphenolic Compoundsmentioning

confidence: 99%

Dendrimers as Nanocarriers for the Delivery of Drugs Obtained from Natural Products

Deng

Wang

et al. 2023

Polymers

View full text Add to dashboard Cite

Natural products have proven their value as drugs that can be therapeutically beneficial in the treatment of various diseases. However, most natural products have low solubility and poor bioavailability, which pose significant challenges. To solve these issues, several drug nanocarriers have been developed. Among these methods, dendrimers have emerged as vectors for natural products due to their superior advantages, such as a controlled molecular structure, narrow polydispersity index, and the availability of multiple functional groups. This review summarizes current knowledge on the structures of dendrimer-based nanocarriers for natural compounds, with a particular focus on applications in alkaloids and polyphenols. Additionally, it highlights the challenges and perspectives for future development in clinical therapy.

show abstract

“…The numerous functional groups on the surface of the PAMAM dendrimers can also be relatively easily converted into various different ones, thus allowing for additional tailoring of properties. Promising applications include drug delivery, imaging or nanotechnology [ 5 , 6 , 7 ]. Hyperbranched polyesters are an attractive polymer class with promising application potential.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Morphology Characteristics of New Highly Branched Polycaprolactone PCL

Zioło,

Mossety-Leszczak,

Walczak

et al. 2024

Molecules

View full text Add to dashboard Cite

A simple and efficient method for the synthesis of biodegradable, highly branched polycaprolactone (PCL) is presented. The solvent-free (bulk) reaction was carried out via ring opening polymerization (ROP), catalyzed by tin octanoate Sn(Oct)2, and it employed hyperbranched polyamide (HPPA) as a macro-initiator. The core–shell structure of the obtained products (PCL-HPPA), with the hyperbranched HPPA core and linear PCL chains as shell, was in the focus of the product characterization. 1H nuclear magnetic resonance (1H NMR) and elemental analysis confirmed the covalent incorporation of the HPPA in the products, as well as a high degree of grafting conversion of its amino functional groups. Confocal Raman Micro spectroscopy, and especially Time-of-Flight Secondary Ion Mass Spectrometry, further supported the existence of a core–shell structure in the products. Direct observation of macromolecules by means of cryogenic transmission electron microscopy, as well as gel permeation chromatography (GPC), suggested the existence of a minor ‘aggregated’ product fraction with multiple HPPA cores, which was attributed to transesterification reactions. Differential scanning calorimetry, as well as X-ray diffraction, demonstrated that the PCL-HPPA polymers displayed a similar degree of crystallinity to linear neat PCL, but that the branched products possessed smaller and less regular crystallites.

show abstract

Facile synthesis of curcumin-containing poly(amidoamine) dendrimers as pH-responsive delivery system for osteoporosis treatment

Cited by 8 publications

References 75 publications

Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development

Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development

Dendrimers as Nanocarriers for the Delivery of Drugs Obtained from Natural Products

Synthesis and Morphology Characteristics of New Highly Branched Polycaprolactone PCL

Contact Info

Product

Resources

About