Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents

Le, Wenjun; Cui, Shaobin; Chen, Xin; Zhu, Huanhuan; Chen, Bingdi; Cui, Zheng

doi:10.3390/nano6040065

Cited by 30 publications

(30 citation statements)

References 31 publications

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“…This is indicative that R1 signal increase is as a result of the formation of Gd-based nanoparticles. The boost occurred as a result of the shortening of the longitudinal relaxation time (T1) [ 40 , 41 ] due higher surface area to volume ratio of AuNPs coated on the surface of the nanoparticles, which improves water solubility [ 41 ] and molecule movement, and proton exchange within the

/LDH lattice [ 42 , 43 ]. The phenomenon is suspected to be connected with the change in structure of the nanohybrid after AuNPs surface coating, as observed in the GAGZAu TEM and FESEM micrographs.…”

Section: Resultsmentioning

confidence: 99%

Gadolinium-Doped Gallic Acid-Zinc/Aluminium-Layered Double Hydroxide/Gold Theranostic Nanoparticles for a Bimodal Magnetic Resonance Imaging and Drug Delivery System

Usman¹,

Hussein²,

Fakurazi

et al. 2017

Nanomaterials

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We have developed gadolinium-based theranostic nanoparticles for co-delivery of drug and magnetic resonance imaging (MRI) contrast agent using Zn/Al-layered double hydroxide as the nanocarrier platform, a naturally occurring phenolic compound, gallic acid (GA) as therapeutic agent, and Gd(NO3)3 as diagnostic agent. Gold nanoparticles (AuNPs) were grown on the system to support the contrast for MRI imaging. The nanoparticles were characterized using techniques such as Hi-TEM, XRD, ICP-ES. Kinetic release study of the GA from the nanoparticles showed about 70% of GA was released over a period of 72 h. The in vitro cell viability test for the nanoparticles showed relatively low toxicity to human cell lines (3T3) and improved toxicity on cancerous cell lines (HepG2). A preliminary contrast property test of the nanoparticles, tested on a 3 Tesla MRI machine at various concentrations of GAGZAu and water (as a reference) indicates that the nanoparticles have a promising dual diagnostic and therapeutic features to further develop a better future for clinical remedy for cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Gadolinium-Doped Gallic Acid-Zinc/Aluminium-Layered Double Hydroxide/Gold Theranostic Nanoparticles for a Bimodal Magnetic Resonance Imaging and Drug Delivery System

Usman¹,

Hussein²,

Fakurazi

et al. 2017

Nanomaterials

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“…Results indicated that there was no significant cytotoxicity (cell viability .80%) for Gd-Au NCs against both COLO-357 ( Figure 3A) and 293T cells ( Figure 3B) at all the concentrations tested, which was consistent with our previously published results. 28 For Gd-Au-NC-GPC-1, no significant cytotoxicity was observed in 293T cells at all concentrations tested, which was similar to Gd-Au NCs ( Figure 3B). However, Gd-Au-NC-GPC-1 showed dose-dependent cytotoxicity (cell viability: from 75.7% to 37.4%) against COLO-357 cells at relatively high concentrations (concentrations: from 30 to 150 mg/L; Figure 3A), which may be associated with complement-dependent cytotoxicity.…”

Section: Cell Toxicity Of Gd-au-nc-gpc-1mentioning

confidence: 55%

“…Gd-Au NCs were prepared according to the methods previously reported by our group. 28 BSA, commonly employed as a substrate for biomineralization, was selected as the model protein for this study. Upon adding HAuCl 4 and GdCl 3 to the aqueous BSA solution, the protein molecules sequestered and entrapped Au and Gd ions.…”

Section: Resultsmentioning

confidence: 99%

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Glypican-1-antibody-conjugated Gd-Au nanoclusters for FI/MRI dual-modal targeted detection of pancreatic cancer

Huang¹,

Fan²,

Zhu³

et al. 2018

IJN

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IntroductionPancreatic cancer (PC) has a poor prognosis with high mortality, due to the lack of effective early diagnostic and prognostic tools.Materials and methodsIn order to target and diagnose PC, we developed a dual-modal imaging probe using Glypican-1 (GPC-1) antibody conjugated with Gd–Au nanoclusters (NCs; Gd-Au-NC-GPC-1). GPC-1 is a type of cell surface heparan sulfate proteoglycan, which is often highly expressed in PC. The probe was successfully prepared with a hydrodynamic diameter ranging from 13.5 to 24.4 nm.ResultsSpectral characteristics showed absorption at 280 nm and prominent emission at 650 nm. Confocal microscopic imaging showed effective detection of GPC-1 highly expressed PC cells by Gd-Au-NC-GPC-1, which was consistent with flow cytometry results. In vitro relaxivity characterization demonstrated that the r1 value of the probe was 17.722 s−1 mM−1 Gd, which was almost 4 times higher compared with that of Gd-diethylenetriaminepentacetate (DTPA; r1 value =4.6 s−1 mM−1 Gd). Gd-Au-NC-GPC-1 exhibited similar magnetic resonance (MR) signals when compared to Gd-DTPA even at lower Gd concentrations. Much higher MR signals were registered in PC cells (COLO-357) compared with normal cells (293T). Furthermore, Gd-Au-NC-GPC-1 could effectively detect PC cells in vivo by dual-modal fluorescence imaging/magnetic resonance imaging (FI/MRI) at 30 minutes postinjection. In addition, Gd-Au-NC-GPC-1 did not show significant biotoxicity to normal cells at tested concentrations both in vitro and in vivo.ConclusionGd-Au-NC-GPC-1 has demonstrated to be a promising dual-modal FI/MRI contrast agent for targeted diagnosis of PC.

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“…Over the past decades, gold (Au) nanostructures have received widespread research interests, due to their fascinating size- and shape-dependent physicochemical properties [ 1 , 2 , 3 , 4 , 5 , 6 ], and their various promising applications in catalysis [ 7 , 8 ], chemical sensing [ 9 , 10 , 11 , 12 ], plasmonics [ 13 ], and surface-enhanced Raman scattering (SERS) [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. In order to tune their unique properties and further improve their performance, Au nanostructures with diverse geometric features, including plate [ 23 ], cube [ 24 ], cage [ 25 ], wire [ 26 ], sphere [ 27 ], decahedron [ 28 ], and branched nanostructures [ 29 ] have been synthesized through a rich variety of chemical methods.…”

Section: Introductionmentioning

confidence: 99%

Galvanic-Cell-Reaction-Driven Deposition of Large-Area Au Nanourchin Arrays for Surface-Enhanced Raman Scattering

Sun

et al. 2018

Nanomaterials

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Here we report a low-cost synthetic approach for the direct fabrication of large-area Au nanourchin arrays on indium tin oxide (ITO) via a facile galvanic-cell-reaction-driven deposition in an aqueous solution of chloroauric acid and poly(vinyl pyrrolidone) (PVP). The homogeneous Au nanourchins are composed of abundant sharp nanotips, which can served as nanoantennas and increase the local electromagnetic field enhancement dramatically. Finite element theoretical calculations confirm the strong electromagnetic field can be created around the sharp nanotips and located in the nanogaps between adjacent tips of the Au nanourchins. In addition, the interparticle nanogaps between the neighboring Au nanourchins may create additional hotspots, which can induce the higher electromagnetic field intensity. By using rhodamine 6G as a test molecule, the large-area Au nanourchin arrays on ITO exhibit active, uniform, and reproducible surface-enhanced Raman scattering (SERS) effect. To trial their practical application, the Au nanourchin arrays are utilized as SERS substrates to detect 3,3’,4,4’-tetrachlorobiphenyl (PCB-77) one congener of polychlorinated biphenyls (PCBs) as a notorious class of persistent organic pollutants. The characteristic Raman peaks can be still identified when the concentration of PCB-77 is down to 5 × 10−6 M.

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Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents

Cited by 30 publications

References 31 publications

Gadolinium-Doped Gallic Acid-Zinc/Aluminium-Layered Double Hydroxide/Gold Theranostic Nanoparticles for a Bimodal Magnetic Resonance Imaging and Drug Delivery System

Gadolinium-Doped Gallic Acid-Zinc/Aluminium-Layered Double Hydroxide/Gold Theranostic Nanoparticles for a Bimodal Magnetic Resonance Imaging and Drug Delivery System

Glypican-1-antibody-conjugated Gd-Au nanoclusters for FI/MRI dual-modal targeted detection of pancreatic cancer

Galvanic-Cell-Reaction-Driven Deposition of Large-Area Au Nanourchin Arrays for Surface-Enhanced Raman Scattering

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