Facile synthesis of heterobimetallic [FeII(µ-diphosphine)RuII] and homobimetallic [FeII(µ-diphosphine)FeII] complexes and their in vitro cytotoxic activity on cisplatin-resistant cancer cells

BenYosef, Danya; Romano, Dario; Hadiji, Mouna; Dyson, Paul J.; Blom, Burgert

doi:10.1016/j.ica.2020.119731

Cited by 9 publications

(1 citation statement)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Structures of cyclopentadienyl iron complexes that show anticancer activity (plus year of publication). I ) L=PPh 2 (alkyl), Y=C(O)Me (2020); [10a] L=CO, Y=Cl, Br, I, NCS, SCN (2016); [10b] L=PPh 3 or related ring‐substituted molecule, Y=I (2017) [10c] . II ) R=Ph, 4‐C 6 H 4 CO 2 H or 4‐C 6 H 4 F, R′=4‐C 6 H 4 NH 2 , X=PF 6 (2017); [10c] R=Ph, R′=aryl or vinyl, X=CF 3 SO 3 (2020) [11c] .…”

Section: Introductionmentioning

confidence: 99%

Easily Available, Amphiphilic Diiron Cyclopentadienyl Complexes Exhibit in Vitro Anticancer Activity in 2D and 3D Human Cancer Cells through Redox Modulation Triggered by CO Release

Biancalana

Franco

Ciancaleoni

et al. 2021

Chemistry A European J

View full text Add to dashboard Cite

A straightforward two‐step procedure via single CO removal allows the conversion of commercial [Fe2Cp2(CO)4] into a range of amphiphilic and robust ionic complexes based on a hybrid aminocarbyne/iminium ligand, [Fe2Cp2(CO)3{CN(R)(R’)}]X (R, R’=alkyl or aryl; X=CF3SO3 or BF4), on up to multigram scales. Their physicochemical properties can be modulated by an appropriate choice of N‐substituents and counteranion. Tested against a panel of human cancer cell lines, the complexes were shown to possess promising antiproliferative activity and to circumvent multidrug resistance. Interestingly, most derivatives also retained a significant cytotoxic activity against human cancer 3D cell cultures. Among them, the complex with R=4‐C6H4OMe and R’=Me emerged as the best performer of the series, being on average about six times more active against cancer cells than a noncancerous cell line, and displayed IC50 values comparable to those of cisplatin in 3D cell cultures. Mechanistic studies revealed the ability of the complexes to release carbon monoxide and to act as oxidative stress inducers in cancer cells.

show abstract