Facile Synthesis of Hollow Fe3O4-rGO Nanocomposites for the Electrochemical Detection of Acetaminophen

Abstract

Acetaminophen (AC) is one of the most popular pharmacologically active substances used as an analgesic and antipyretic drug. Herein, a new type of hollow Fe3O4-rGO/GCE electrode was prepared for electrochemical detection of AC through a three-step approach involving a solvothermal method for the synthesis of hollow Fe3O4 and the chemical reduction of graphene oxide (GO) for reduced graphene oxide (rGO) and Fe3O4-rGO nanocomposites modified on the glassy carbon electrode (GCE) surface. The as-prepared Fe3O4-rGO nanocomposites were characterized using a transmission electron microscope (TEM), X-ray diffraction (XRD), and a magnetic measurement system (SQUID-VSM). The magnetic Fe3O4-rGO/GCE electrodes were employed for the electrochemical detection of AC using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and square wave voltammetry (SWV) and exhibited an ultra-high selectivity and accuracy, a low detection limit of 0.11 µmol/L with a wider linear range from 5 × 10−7 to 10−4 mol/L, and high recovery between 100.52% and 101.43%. The obtained Fe3O4-rGO-modified GCE displays great practical significance for the detection of AC in drug analysis.

Layered Yttrium Oxide Reinforced Graphene Oxide Electrode Surface for Voltammetric Determination of Paracetamol

“…In Table 1, the analytical outputs for the PCM sensor studies were compared with those of other PCM sensors [38][39][40][41][42]. While selecting the studies, sensors containing GO or reduced GO were preferred.…”

Electrochemical Detection of Flutamide by the Composite of Complex Based on Thiacalix[4]arene Derivatives and Reduced Graphene Oxide

“…Dispersing carbon materials on the surface of MOFs can make the materials have a larger specific surface area and a higher conductivity, which is conducive to the enhancement of electrocatalytic signals. − The MOFs constructed by thiacalix[4]arene derivatives have attracted much attention due to their abundant active sites and large cavity structure. − However, it also has its shortcomings, such as poor electrical conductivity and low performance in the electrochemical detection of drugs. To improve electrical conductivity, carbon-based materials with good conductivity, high porosity, and large specific surface area are introduced into MOFs to form composite materials, which can effectively solve this problem. − The structure of reduced graphene oxide (RGO) is relatively stable, and it has a large specific surface area, good electrical conductivity, and some residual carboxyl, hydroxyl, and epoxy groups on the surface. , Mesoporous carbon (MC) has a large surface area, good conductivity, and high porosity so it has good adsorption capacity . Although the specific surface area of multi-walled carbon nanotubes (MWCNTs) is not as large as MC and RGO, it has better chemical stability and electrical conductivity .…”

“…35−38 The structure of reduced graphene oxide (RGO) is relatively stable, and it has a large specific surface area, good electrical conductivity, and some residual carboxyl, hydroxyl, and epoxy groups on the surface. 39,40 Mesoporous carbon (MC) has a large surface area, good conductivity, and high porosity so it has good adsorption capacity. 41 Although the specific surface area of multi-walled carbon nanotubes (MWCNTs) is not as large as MC and RGO, it has better chemical stability and electrical conductivity.…”

A Facile Glycerol-Assisted Synthesis of Low-Cu2+-Doped CoFe2O4 for Electrochemical Sensing of Acetaminophen

“…Several procedures have been developed to obtain ferrite nanoparticles [18][19][20][21]. The influence of cosolvents or chelating agents and preparation times have been studied, giving interesting results, where it has been sought to minimize the agglomeration of particles and control their size and morphologies [22][23][24][25][26][27][28][29][30][31][32].…”