Facile synthesis of NaYF4:Ln/NaYF4:Eu composite with up-conversion and down-shifting luminescence

Qin, Xiaohong; Zhang, Xiaoxiong; Zhang, Wenjun; Li, Cuiliu; Zhu, Chengyu

doi:10.1016/j.jphotochem.2020.112388

Cited by 5 publications

(1 citation statement)

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“…Among the lanthanide-based platforms for fluorescence imaging (FI), a special attention is paid to fluorides, because they have lower vibrational energy than oxides, and consequently, the quenching of the exited state of Ln cations is minimized, which results in high quantum efficiency of the luminescence [ 5 ]. In recent years, a lot of research has been focused on application of down- (DC) and up-conversion (UC) lanthanide fluorides [ 3 , 4 , 6 , 7 ]. Compared to traditionally used fluorescent organic dyes and quantum dots, lanthanide-based fluorides have a number of advantages, such as sharp emission bandwidth, long lifetime, tunable emission, high photostability, low cytotoxicity, and low background autofluorescence for DC and UC fluorescence.…”

Section: Introductionmentioning

confidence: 99%

Colloidally Stable P(DMA-AGME)-Ale-Coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ Nanoparticles as a Multimodal Contrast Agent for Down- and Upconversion Luminescence, Magnetic Resonance Imaging, and Computed Tomography

et al. 2021

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Multimodal imaging, integrating several modalities including down- and up-conversion luminescence, T1- and T2(T2*)-weighted MRI, and CT contrasting in one system, is very promising for improved diagnosis of severe medical disorders. To reach the goal, it is necessary to develop suitable nanoparticles that are highly colloidally stable in biologically relevant media. Here, hydrophilic poly(N,N-dimethylacrylamide-N-acryloylglycine methyl ester)-alendronate-[P(DMA-AGME)-Ale]-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) followed by coating with the polymer. The particles were tho-roughly characterized by a dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray energy dispersive spectroscopy (EDAX), selected area electron diffraction (SAED), elemental ana-lysis and fluorescence spectroscopy. Aqueous particle dispersions exhibited excellent colloidal stability in water and physiological buffers. In vitro toxicity assessments suggested no or only mild toxicity of the surface-engineered Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ particles in a wide range of concentrations. Internalization of the particles by several types of cells, including HeLa, HF, HepG2, and INS, was confirmed by a down- and up-conversion confocal microscopy. Newly developed particles thus proved to be an efficient contrast agent for fluorescence imaging, T1- and T2(T2*)-weighted magnetic resonance imaging (MRI), and computed tomography (CT).

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Section: Introductionmentioning

confidence: 99%