Facile Synthesis of new 7-morpholino-6-(Aryl-1,3,4-oxadiazol)-1,8-naphthyridines and, evaluation of Antimicrobial and molecular Docking studies

Abstract

The new series of biologically potential antibacterial and anti-fungal agents of 7-morpholino-6-(5-ary-1,3,4-oxadiazol)-1,8-naphthyridine-2-carbonitrile scaffolds successfully synthesised by using the mild catalyst (FeCl3.6H2O) obtained good yields. The structures of the newly synthesized final target molecules established by various techniques IR, 1H NMR, 13C NMR, and Mass data. Activity of In vitro Antimicrobial studies of the new products were investigated against bacterial and fungal strains in compare with the clinical drugs Ampicillin, Grieseofulvin, compounds 7c and 7g demonstrated highest activity against pathogenic strains. Moreover, products were docked against target protein receptor (PDB ID: 8g4d), Docking results displayed that 7c and 7g are excellent binding interactions with the protein.