Facile synthesis of novel dithioacetal–naphthalene derivatives as potential activators for plant resistance induction

Ji, Rui-Ru; Shi, Wang-Ming; Tian, Da-Yu; Zhang, G. P.; Wang, H.

doi:10.1039/c9ra06843k

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…The former was synthesized by the esterification of phenylpyruvic acid using methyl chloride and DBU [ 37 ]. The latter was afforded by a substitution reaction between 4-hydroxybenzaldehyde and 1-(chloromethyl)naphthalene, in the presence of oven-dried K 2 CO 3 [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition

et al. 2023

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PPARγ represents a key target for the treatment of type 2 diabetes and metabolic syndrome. To avoid serious adverse effects related to the PPARγ agonism profile of traditional antidiabetic drugs, a new opportunity is represented by the development of molecules acting as inhibitors of PPARγ phosphorylation by the cyclin-dependent kinase 5 (CDK5). Their mechanism of action is mediated by the stabilization of the PPARγ β-sheet containing Ser273 (Ser245 in PPARγ isoform 1 nomenclature). In this paper, we report the identification of new γ-hydroxy-lactone-based PPARγ binders from the screening of an in-house library. These compounds exhibit a non-agonist profile towards PPARγ, and one of them prevents Ser245 PPARγ phosphorylation by acting mainly on PPARγ stabilization and exerting a weak CDK5 inhibitory effect.

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Section: Methodsmentioning

confidence: 99%

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition

et al. 2023

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“…Phytotoxic activities against tobacco and anti-TMV activity were assessed according to the aforementioned method (Ji et al, 2019;Wang et al, 2012). Tobacco mosaic virus (TMV) was purified.…”

Section: Evaluation Of Phytotoxic Activities Against Tobacco and Anti...mentioning

confidence: 99%

Discovery of Novel α-Aminophosphonates with Hydrazone as Potential Antiviral Agents Combined With Active Fragment and Molecular Docking

Tian

Wang

et al. 2022

Front. Chem.

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A series of novel α-aminophosphonate derivatives containing hydrazone were designed and synthesized based on active fragments. Bioassay results demonstrated that title compounds possessed good activities against tobacco mosaic virus. Among them, compounds 6a, 6g, 6i, and 6j were equivalent to the commercial antiviral agents like dufulin. On structure optimization-based molecular docking, compound 6k was synthesized and displayed excellent activity with values of 65.1% curative activity, 74.3% protective activity, and 94.3% inactivation activity, which were significantly superior to the commercial antiviral agents dufulin and ningnanmycin. Therefore, this study indicated that new lead compounds could be developed by adopting a joint strategy with active fragments and molecular docking.

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“…The results indicated that compound 116 (Figure 35) exhibited the best activity against PVY in vivo, with the EC 50 value of protection activity of 122 μg/mL, which was distinctively better than Ribavirin and Ningnanmycin. Ji et al [118] reported a series of novel dithioacetalnaphthalenes and evaluated for their in vivo antiviral activities against TMV and CMV. The results indicated that most compounds exhibited better activity against CMV than against TMV.…”

Section: Antiviral Activitymentioning

confidence: 99%

Recent achievements on the agricultural applications of thioether derivatives: A 2010–2020 decade in review

Yang²,

Wang

et al. 2021

Journal of Heterocyclic Chem

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Thioether derivatives, an important synthetic strategy in drug discovery, are acquiring more importance in plant protection field in recent years because of their broad spectrum of agricultural activities, such as antifungal, antibacterial, insecticidal, acaricidal, nematocidal, antiviral, herbicidal, and plant growthregulating activity. Thioethers and their analogues have been an area of great interest in recent years. This review summarizes the structure and agricultural activities of the thioether derivatives as reported in the literature that mainly covers the past 10 years from 2010 to 2020 as well as may contribute to a better understanding of thioether derivatives as efficient agricultural agents and provide some ideas on the development of novel pesticides.

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Facile synthesis of novel dithioacetal–naphthalene derivatives as potential activators for plant resistance induction

Abstract: In this paper, a series of novel dithioacetal–naphthalenes were designed and synthesized for plant immunity.

Cited by 7 publications

References 28 publications

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition

Discovery of Novel α-Aminophosphonates with Hydrazone as Potential Antiviral Agents Combined With Active Fragment and Molecular Docking

Recent achievements on the agricultural applications of thioether derivatives: A 2010–2020 decade in review

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