Facile Synthesis of Novel Indeno[1,2‐b]indol‐10‐one Derivatives by the Oxidation with DDQ.

Abstract

Fused pyrrole derivatives R 0160Facile Synthesis of Novel Indeno[1,2-b]indol-10-one Derivatives by the Oxidation with DDQ. -A quite convenient method for the synthesis of the biologically active title compounds (V), important intermediates in the synthesis of some selective estrogen receptor modulators, based on the intramolecular cyclization of readily available hydrazones (III) according to the Fischer indole synthesis followed by DDQ oxidation, is described. -(WANG, J.-B.; JI, Q.-G.; XU, J.; WU*, X.-H.; XIE, Y.-Y.; Synth.