Facile synthesis of substituted 2-aroylbenzo[b]thiophen-3-ols to form novel triazole hybrids using click chemistry

Abstract

In the presence of triethylamine, 2-mercaptobenzoic acid (6) reacts with aryl bromomethyl ketones (8) to produce benzothiophenes (5), which can be subjected to a click reaction to construct benzothiophene-triazole hybrids (14).