Facile Synthesis of Ultrasmall, Highly Stable, and Biocompatible Gold Nanoparticles Stabilized with Lipoic Acid: Cytotoxicity and Structural Characterization

Cornejo-Monroy, Delfino; Sánchez-Santamaría, Betania; Martínez-Gómez, Erwin Adán; Olivas–Armendáriz, I.; Villanueva-Montellano, Alfredo; Arias-Cerón, J.S.; Castaño, V. M.

doi:10.1134/s199507801906003x

Cited by 2 publications

(5 citation statements)

References 26 publications

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“…To obtain degradation data of GNPs@LA under a CSADT, several samples were synthesized following the methodology reported by Cornejo et al [19] and using NaCl as an acceleration factor. The stress test levels were based on an exploratory study, leaving three different levels of effort for three different populations.…”

Section: Methodology and Analysis Of Degradation Data Under The Wiene...mentioning

confidence: 99%

“…Based on the bottom-up approach, particularly the colloidal method; gold nanoparticles with an average size of 2.5 nm were synthesized and stabilized using gold chloride as a precursor, sodium borohydride as a reducer, and lipoic acid as a stabilizer, following the methodology reported by Cornejo-Monroy et al [19].…”

Section: Synthesis Of Gnps@lamentioning

confidence: 99%

“…GNPs@LA analyzed in this study are spherical at 2.5 nm, highly stable in colloid as well as a powder; they are stabilized with lipoic acid which prevents agglomeration and creates functional groups for bio-conjugation, and also do not present toxic effects at the cellular level based on ISO 10993-5 [19]. However, there are no studies that allow us to determine the lifetime of the nanomaterial.…”

Section: Introductionmentioning

confidence: 99%

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Estimation of the lifespan distribution of gold nanoparticles stabilized with lipoic acid by accelerated degradation tests and wiener process

Sánchez-Santamaría¹,

Mederos²,

Cornejo-Monroy³

et al. 2022

Nano Ex.

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Accelerated degradation tests (ADT) are widely used in the manufacturing industry to obtain information on the reliability of components and materials, by degrading the lifespan of the product by applying an acceleration factor that damage to the material. The main objective is to obtain fast information which is modeled to estimate the characteristics of the material life under normal conditions of use and to save time and expenses. The purpose of this work is to estimate the lifespan distribution of gold nanoparticles stabilized with lipoic acid (GNPs@LA) through accelerated degradation tests applying sodium chloride (NaCl) as an acceleration factor. For this, the synthesis of GNPs@LA was carried out, a constant stress ADT (CSADT) was applied, and the non-linear Wiener process was proposed with random effects, error measures, and different co-variability for the adjustment of the degradation signals. The information obtained with the test and analysis allows us to obtain the life distribution in GNPs@LA, the results make it possible to determine the guaranteed time for possible commercialization and successful application based on the stability of the material. In addition, for the evaluation and selection of the model, the Akaike and Bootstrapping criteria were used.

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Section: Methodology and Analysis Of Degradation Data Under The Wiene...mentioning

confidence: 99%

Section: Synthesis Of Gnps@lamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Estimation of the lifespan distribution of gold nanoparticles stabilized with lipoic acid by accelerated degradation tests and wiener process

Sánchez-Santamaría¹,

Mederos²,

Cornejo-Monroy³

et al. 2022

Nano Ex.

Self Cite

View full text Add to dashboard Cite

show abstract

“…GNPs@LA analyzed in this study are spherical of 2.5 nm, highly stable in colloid as well as powder; they are stabilized with lipoic acid which prevents agglomeration and creates functional groups for bio-conjugation, and also do not present toxic effects at the cellular level based on ISO 10993-5 [19]. However, there are no studies that allow us to determine the lifetime of the nanomaterial.…”

Section: Introductionmentioning

confidence: 99%

“…Finally, section 4 gives the conclusions of our work. Based on the bottom-up approach, particularly the colloidal method; gold nanoparticles with an average size of 2.5 nm were synthetized and stabilized using gold chloride as a precursor, sodium borohydride as a reducer and lipoic acid as a stabilizer, following the methodology reported by Cornejo-Monroy et al [19].…”

Section: Introductionmentioning

confidence: 99%

Estimation of the Lifespan Distribution of Gold Nanoparticles Stabilized with Lipoic Acid by Accelerated Degradation Tests and Wiener Process

Sánchez-Santamaría¹,

Mederos²,

Cornejo-Monroy³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Accelerated degradation tests (ADT) are widely used in the manufacturing industry to obtain information on the reliability of components and materials, through degrading the lifespan of the product by applying an acceleration factor which causes damage to the material. The main objective is to obtain fast information which is modeled to estimate the characteristics of the material life under normal conditions of use and to save time and expenses. The purpose of this work is to estimate the lifespan distribution of gold nanoparticles stabilized with lipoic acid (GNPs@LA) through accelerated degradation tests applying sodium chloride (NaCl) as an acceleration factor. For this, the synthesis of GNPs@LA was carried out, a constant stress ADT (CSADT) was applied, and the non-linear Wiener process was proposed with random effects, error measures and different covariability for the adjustment of the degradation signals. The information obtained with the test and analysis allows us to obtain the life distribution in GNPs@LA, the results make possible to determine the guaranteed time for a possible commercialization and successful application based on the stability of the material. In addition, for the evaluation and selection of the model, the Akaike and Bootstraping criteria were used.

show abstract

Facile Synthesis of Ultrasmall, Highly Stable, and Biocompatible Gold Nanoparticles Stabilized with Lipoic Acid: Cytotoxicity and Structural Characterization

Cited by 2 publications

References 26 publications

Estimation of the lifespan distribution of gold nanoparticles stabilized with lipoic acid by accelerated degradation tests and wiener process

Estimation of the lifespan distribution of gold nanoparticles stabilized with lipoic acid by accelerated degradation tests and wiener process

Estimation of the Lifespan Distribution of Gold Nanoparticles Stabilized with Lipoic Acid by Accelerated Degradation Tests and Wiener Process

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