Facilitated physical activity as a treatment for depressed adults: randomised controlled trial

Chalder, Melanie; Wiles, Nicola; Campbell, John; Hollinghurst, Sandra; Haase, Anne M.; Taylor, Adrian; Fox, Keith R.; Costelloe, Céire; Searle, Aidan; Baxter, Helen; Winder, Rachel; Wright, Christine; Turner, Katrina; Calnan, Michael; Lawlor, Debbie A.; Peters, Tim J.; Sharp, Deborah; Montgomery, Alan; Lewis, Glyn

doi:10.1136/bmj.e2758

Cited by 185 publications

(177 citation statements)

References 24 publications

Supporting

Mentioning

168

Contrasting

Unclassified

Order By: Relevance

“…43 Researchers have conducted several randomized controlled trials (RCTs) to further elucidate the effect that PA and its optimal prescription (i.e., frequency, intensity, and duration) may have in the treatment of depression. [44][45][46][47] A recent Cochrane review summarized the findings of 30 RCTs to determine the effectiveness of exercise in the treatment of depression. For 28 RCTs, exercise had a moderate clinical effect on depression symptoms.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity Patterns among U.S. Adults with and without Serious Psychological Distress

et al. 2014

View full text Add to dashboard Cite

Objective. A physically active lifestyle is recommended for overall healthboth physical and mental. Serious psychological distress (SPD) is associated with adverse health behaviors. We compared patterns of physical activity (PA) among adults with and without SPD using current public health guidelines for PA and examined whether adults with SPD were physically active at recommended levels.Methods. We used data from the 2009 Behavioral Risk Factor Surveillance System (BRFSS) to assess SPD using the Kessler 6 (K6) scale of nonspecific psychological distress and PA categories based on the 2008 U.S. Department of Health and Human Services guidelines. Complete data were available for 78,886 adults in 16 states that used an optional BRFSS mental illness and stigma module containing the K6 scale. We performed multiple logistic regression analyses to estimate prevalence ratios (PRs) and 95% confidence intervals (CIs).results. The unadjusted prevalence of SPD was 3.9% (95% CI 3.6, 4.2), and the age-adjusted prevalence of SPD was 3.8% (95% CI 3.5, 4.1). After adjusting for age, sex, race/ethnicity, education, employment, body mass index, smoking status, and heavy drinking, adults with SPD were significantly less likely to be physically active at recommended levels than adults without SPD. PRs were attenuated but remained significant after further adjustment for limitations to PA.conclusion. Adults with SPD are less likely to meet current PA recommendations than adults without SPD, highlighting the need for targeted interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

Physical Activity Patterns among U.S. Adults with and without Serious Psychological Distress

et al. 2014

View full text Add to dashboard Cite

show abstract

“…It is of note, however, that baseline severity in CoBalT was similar to other RCTs of depression in the UK. 109,185,186 The CoBalT sample was nevertheless more ill in terms of chronicity, number of previous episodes, comorbidities and non-response to medication. This suggests that to capture the extent of illness that we see clinically then we need to account for both severity and chronicity, especially in those whose symptoms are resistant to antidepressants.…”

Section: Demographic and Life Factorsmentioning

confidence: 99%

Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: the CoBalT randomised controlled trial

Wiles

Thomas

Abel

et al. 2014

Health Technology Assessment

View full text Add to dashboard Cite

“…For example, a recent community-based trial in the UK involving 361 adults aged 18-69 years found that the addition of a facilitated physical activity intervention to usual care did not improve depression outcomes. 26 However, an important 418 feature of our trial was the inclusion of structured, supervised exercise sessions for the duration of the study. This particular feature has been linked to better outcomes in previous exercise treatment studies.…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

Exercise and internet-based cognitive–behavioural therapy for depression: multicentre randomised controlled trial with 12-month follow-up

et al. 2016

View full text Add to dashboard Cite

BackgroundEvidence-based treatment of depression continues to grow, but successful treatment and maintenance of treatment response remains limited.AimsTo compare the effectiveness of exercise, internet-based cognitive–behavioural therapy (ICBT) and usual care for depression.MethodA multicentre, three-group parallel, randomised controlled trial was conducted with assessment at 3 months (post-treatment) and 12 months (primary end-point). Outcome assessors were masked to group allocation. Computer-generated allocation was performed externally in blocks of 36 and the ratio of participants per group was 1:1:1. In total, 945 adults with mild to moderate depression aged 18–71 years were recruited from primary healthcare centres located throughout Sweden. Participants were randomly assigned to one of three 12-week interventions: supervised group exercise, clinician-supported ICBT or usual care by a physician. The primary outcome was depression severity assessed by the Montgomery–Åsberg Depression Rating Scale (MADRS).ResultsThe response rate at 12-month follow-up was 84%. Depression severity reduced significantly in all three treatment groups in a quadratic trend over time. Mean differences in MADRS score at 12 months were 12.1 (ICBT), 11.4 (exercise) and 9.7 (usual care). At the primary end-point the group × time interaction was significant for both exercise and ICBT. Effect sizes for both interventions were small to moderate.ConclusionsThe long-term treatment effects reported here suggest that prescribed exercise and clinician-supported ICBT should be considered for the treatment of mild to moderate depression in adults.

show abstract

Facilitated physical activity as a treatment for depressed adults: randomised controlled trial

Abstract: Objective To investigate the effectiveness of facilitated physical activity as an adjunctive treatment for adults with depression presenting in primary care.Design Pragmatic, multicentre, two arm parallel randomised controlled trial.Setting General practices in Bristol and Exeter.

Cited by 185 publications

References 24 publications

Physical Activity Patterns among U.S. Adults with and without Serious Psychological Distress

Physical Activity Patterns among U.S. Adults with and without Serious Psychological Distress

Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: the CoBalT randomised controlled trial

Exercise and internet-based cognitive–behavioural therapy for depression: multicentre randomised controlled trial with 12-month follow-up

Contact Info

Product

Resources

About