Facilitating wound bed preparation: properties and clinical efficacy of octenidine and octenidine-based products in modern wound management

Assadian, Dtmh Ojan; Hämmerle, Gilbert; Lahnsteiner, Elisabeth; Simon, Deborah; Antunes, José Neves Paulos; Hallern, Bernd von; Pilcher, Matthew; Price, Juliet; Boulton, Zoe; Hunt, Sharon; Jeffery, Steven

doi:10.12968/jowc.2016.25.sup3.s1

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…On the other hand, OCT is a cationic, surface active antimicrobial compound (its molecular weight is approximately 624 Da), whose mode of action is based on integration with enzymatic systems. As a result, polysaccharides in the cell wall of microorganisms induce leakages in the cytoplasmic membrane and lead to cell death [7,8,35]. It has two non-interacting cation-active centers in its molecule, which are separated by a long aliphatic hydrocarbon chain [8,35].…”

Section: Discussionmentioning

confidence: 99%

“…As a result, polysaccharides in the cell wall of microorganisms induce leakages in the cytoplasmic membrane and lead to cell death [7,8,35]. It has two non-interacting cation-active centers in its molecule, which are separated by a long aliphatic hydrocarbon chain [8,35]. Like other cationic antiseptics, OCT's main target appears to be glycerol phosphates in the bacterial cell membrane.…”

Section: Discussionmentioning

confidence: 99%

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The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains

et al. 2019

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In the post-antibiotic era the issue of bacterial resistance refers not only to antibiotics themselves but also to common antiseptics like octenidine dihydrochloride (OCT). This appears as an emerging challenge in terms of preventing staphylococcal infections, which are both potentially severe and easy to transfer horizontally. Essential oils have shown synergisms both with antibiotics and antiseptics. Therefore the aim of this study was to investigate the impact of lavender essential oil (LEO) on OCT efficiency towards methicillin-resistant S. aureus strains (MRSA). The LEO analyzed in this study increased the OCT’s susceptibility against MRSA strains. Subsequent FTIR analysis revealed cellular wall modifications in MRSA strain cultured in media supplemented with OCT or LEO/OCT. In conclusion, LEO appears to be a promising candidate for an efficient enhancer of conventional antiseptics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains

et al. 2019

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“…Octenidine is a cationic surfactant effective against Gram-positive and Gram-negative bacteria. It features two non-interacting cationic active centres separated by a lengthy aliphatic hydrocarbon chain ( Figure 1 A), which facilitate its linkage with negatively charged surfaces of the microorganisms [ 31 ]. 2-Phenoxyethanol ( Figure 1 B) is an aromatic ether with a 2-hydroxyethyl group substituting on oxygen.…”

Section: Introductionmentioning

confidence: 99%

Antiseptic-Loaded Casein Hydrogels for Wound Dressings

et al. 2023

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Chronic wound treatment accounts for a substantial percentage of the medical expenses worldwide. Improving and developing novel wound care systems can potentially help to handle this problem. Wound dressings loaded with antiseptics may be an important tool for wound care, as they inhibit bacterial growth at the wound site. The goal of the present work was to investigate the potential of using casein hydrogel dressings loaded with two antiseptic drugs, Octiset® or polyhexanide, to treat chronic wounds. Casein-based hydrogels are inexpensive and have several properties that make them suitable for biomedical applications. Two types of casein were used: casein sodium salt and acid casein, with the formulations being labelled CS and C, respectively. The hydrogels were characterised with respect to their physical properties (swelling capacity, water content, morphology, mechanical resistance, and stability), before and after sterilisation, and they showed adequate values for the intended application. The hydrogels of both formulations were able to sustain controlled drug-release for, at least, 48 h. They were demonstrated to be non-irritant, highly haemocompatible, and non-cytotoxic, and revealed good antimicrobial properties against Staphylococcus aureus and Pseudomonas aeruginosa. Steam-heat sterilisation did not compromise the material’s properties. The in vivo performance of C hydrogel loaded with Octiset® was evaluated in a case study with a dog. The efficient recovery of the wounds confirms its potential as an alternative for wound treatment. To our knowledge, this is the first time that wound dressings loaded with Octiset®, one of the most efficient drugs for wound treatment, were prepared and tested.

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“…53,54 PHMB has also been shown to show antibiofilm activity on biofilms, 31,47,48,[55][56][57][58] including wound biofilms. 59,60 Octenidine has also been demonstrated to have antibiofilm activity in in vitro biofilm model assays, 61 and a number of studies have shown HOCl to exhibit antibiofilm activity. 62 Biofilms provide protection to microorganisms and blocks access of bacterial communities resident in the biofilm from antimicrobial agents, 63 which can lead to the emergence of drug-resistant infections.…”

Section: Experimental Assessment Of Anti-biofilm Activitymentioning

confidence: 99%

“…111 Kramer al (2019) 104 comparing an extensive number of antiseptics for the antibacterial activity against test organisms and assessing the cytotoxicity on cultured cells found that PHMB was one of the most suitable antimicrobial agents for use wound antisepsis. PHMB 104 and octenidine 61 balanced the level of antimicrobial activity with the level of in vitro cytotoxicity.…”

Section: Broad-spectrum Efficacy Of Phmbmentioning

confidence: 99%

Effectiveness of a polyhexamethylene biguanide-containing wound cleansing solution using experimental biofilm models

Rippon

Rogers

Westgate³

et al. 2023

J Wound Care

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Objective: Antiseptics are widely used in wound management to prevent or treat wound infections, and have been shown to have antibiofilm efficacy. The objective of this study was to assess the effectiveness of a polyhexamethylene biguanide (PHMB)-containing wound cleansing and irrigation solution on model biofilm of pathogens known to cause wound infections compared with a number of other antimicrobial wound cleansing and irrigation solutions. Method: Staphylococcus aureus and Pseudomonas aeruginosa single-species biofilms were cultured using microtitre plate and Centers for Disease Control and Prevention (CDC) biofilm reactor methods. Following a 24-hour incubation period, the biofilms were rinsed to remove planktonic microorganisms and then challenged with wound cleansing and irrigation solutions. Following incubation of the biofilms with a variety of concentrations of the test solutions (50%, 75% or 100%) for 20, 30, 40, 50 or 60 minutes, remaining viable organisms from the treated biofilms were quantified. Results: The six antimicrobial wound cleansing and irrigation solutions used were all effective in eradicating Staphylococcus aureus biofilm bacteria in both test models. However, the results were more variable for the more tolerant Pseudomonas aeruginosa biofilm. Only one of the six solutions (sea salt and oxychlorite/NaOCl-containing solution) was able to eradicate Pseudomonas aeruginosa biofilm using the microtitre plate assay. Of the six solutions, three (a solution containing PHMB and poloxamer 188 surfactant, a solution containing hypochlorous acid (HOCl) and a solution containing NaOCl/HOCl) showed increasing levels of eradication of Pseudomonas aeruginosa biofilm microorganisms with increasing concentration and exposure time. Using the CDC biofilm reactor model, all six cleansing and irrigation solutions, except for the solution containing HOCl, were able to eradicate Pseudomonas aeruginosa biofilms such that no viable microorganisms were recovered. Conclusion: This study demonstrated that a PHMB-containing wound cleansing and irrigation solution was as effective as other antimicrobial wound irrigation solutions for antibiofilm efficacy. Together with the low toxicity, good safety profile and absence of any reported acquisition of bacterial resistance to PHMB, the antibiofilm effectiveness data support the alignment of this cleansing and irrigation solution with antimicrobial stewardship (AMS) strategies.

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Facilitating wound bed preparation: properties and clinical efficacy of octenidine and octenidine-based products in modern wound management

Abstract: S3 Octenidine dihydrochloride: chemical characteristics and antimicrobial properties S7 Wound cleansing: a key player in the implementation of the TIME paradigm

Cited by 6 publications

References 35 publications

The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains

The Antibacterial Activity of Lavender Essential Oil Alone and In Combination with Octenidine Dihydrochloride against MRSA Strains

Antiseptic-Loaded Casein Hydrogels for Wound Dressings

Effectiveness of a polyhexamethylene biguanide-containing wound cleansing solution using experimental biofilm models

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