Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1

Matsunaga, Toshiyuki; Kamase, Kyoko; Takasawa, Hiroaki; Yamaji, Yukiko; Endo, Shunsuke; El‐Kabbani, Ossama; Ikari, Akira

doi:10.1016/j.cbi.2017.10.028

Cited by 7 publications

(4 citation statements)

References 60 publications

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“…Thus, natural 8-hydroxy-2-methoxy-1,4-naphthoquinone and 5-hydroxy-2-methoxy-1,4naphthoquinone from plant Juglans sinensis and series of synthetic 1,4-NQs derivatives exhibited significant cytotoxicity against human SH-SY5Y and mouse Neuro-2a neuroblastoma cells [21,35]. Exposure to some 1,2-NQs и 1,4-NQs provokes human neuroblastoma cell lines SK-N-SH apoptosis in a ROS-dependent pathway, including DNA damage, mitochondrial dysfunction, and resultant caspase 3 and 9 activation together with GSH decrease, proteasome inactivation and NQO1 upregulation [36]. Treatment of mouse hippocampal neuronal HT22 cells with 2,3-dimethoxy-1,4-naphthoquinone increased cytosolic and mitochondrial ROS and apoptosis, involving CHOP/GADD153 upregulation, JNK and p38 MAPK activation, Bak/Bax activation, mitochondrial membrane potential loss, caspase-9 and caspase-3 activation, PARP cleavage, nucleosomal DNA fragmentation, and intracellular GSH reduction [37].…”

Section: Discussionmentioning

confidence: 99%

Protection Activity of 1,4-Naphthoquinones in Rotenone-Induced Models of Neurotoxicity

Agafonova,

Chingizova,

Chaikina

et al. 2024

Marine Drugs

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The MTS cell viability test was used to screen a mini library of natural and synthetic 1,4-naphthoquinone derivatives (1,4-NQs) from marine sources. This screening identified two highly effective compounds, U-443 and U-573, which showed potential in protecting Neuro-2a neuroblastoma cells from the toxic effects of rotenone in an in vitro model of neurotoxicity. The selected 1,4-NQs demonstrated the capability to reduce oxidative stress by decreasing the levels of reactive oxygen species (ROS) and nitric oxide (NO) in Neuro-2a neuroblastoma cells and RAW 264.7 macrophage cells and displayed significant antioxidant properties in mouse brain homogenate. Normal mitochondrial function was restored and the mitochondrial membrane potential was also regained by 1,4-NQs after exposure to neurotoxins. Furthermore, at low concentrations, these compounds were found to significantly reduce levels of proinflammatory cytokines TNF and IL-1β and notably inhibit the activity of cyclooxygenase-2 (COX-2) in RAW 264.7 macrophages. The results of docking studies showed that the 1,4-NQs were bound to the active site of COX-2, analogically to a known inhibitor of this enzyme, SC-558. Both substances significantly improved the behavioral changes in female CD1 mice with rotenone-induced early stage of Parkinson’s disease (PD) in vivo. It is proposed that the 1,4-NQs, U-443 and U-573, can protect neurons and microglia through their potent anti-ROS and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 99%

Protection Activity of 1,4-Naphthoquinones in Rotenone-Induced Models of Neurotoxicity

Agafonova,

Chingizova,

Chaikina

et al. 2024

Marine Drugs

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“…Many studies demonstrated that PQ can cause toxicity in vivo and in vitro biological system via the redox cycling for the generation of ROS [ 42 , 46 , 47 , 50 , 72 , 78 , 82 ]. Excessive ROS is known to cause DNA damage resulting in gene mutation [ 99 – 103 ].…”

Section: 910-pq and Cellular Toxicitymentioning

confidence: 99%

“…Previous studies demonstrated that 9,10-PQ can elicit adverse cardiovascular effects such as alterations in vascular reactivity [ 48 , 72 , 82 , 145 – 147 ] and aortic ring relaxation [ 53 ]. Exposure to diesel exhaust containing 9,10-PQ was found to diminish humans forearm blood flow through endothelium-dependent and -independent mechanisms [ 148 ].…”

Section: The Role Of 910-pq In Cardiovascular Diseasementioning

confidence: 99%

“…NO production was also suppressed by phenanthraquinone in membrane fraction of BAECs with a concentration-dependent manner by measuring citrulline formation from L-arginine [ 149 ]. Thus, these in vitro and in vivo studies demonstrated that 9,10-PQ can cause an impairment of endothelium-dependent vasorelaxation and are associated with cardiopulmonary-related diseases and mortality ( Table 1 ) [ 48 , 72 , 82 , 147 ].…”

Section: The Role Of 910-pq In Cardiovascular Diseasementioning

confidence: 99%

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Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling

Yang

Ahmed

et al. 2018

BioMed Research International

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Atmospheric pollution has been a principal topic recently in the scientific and political community due to its role and impact on human and ecological health. 9,10-phenanthrenequinone (9,10-PQ) is a quinone molecule found in air pollution abundantly in the diesel exhaust particles (DEP). This compound has studied extensively and has been shown to develop cytotoxic effects both in vitro and in vivo. 9, 10-PQ has been proposed to play a critical role in the development of cytotoxicity via generation of reactive oxygen species (ROS) through redox cycling. This compound also reduces expression of glutathione (GSH), which is critical in Phase II detoxification reactions. Understanding the underlying cellular mechanisms involved in cytotoxicity can allow for the development of therapeutics designed to target specific molecules significantly involved in the 9,10-PQ-induced ROS toxicity. This review highlights the developments in the understanding of the cytotoxic effects of 9, 10-PQ with special emphasis on the possible mechanisms involved.

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Differences in epithelial-mesenchymal-transition in paraquat-induced pulmonary fibrosis in BALB/C and BALB/C (nu/nu) nude mice

Qian

Sun

et al. 2021

Biomedicine & Pharmacotherapy

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Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1

Cited by 7 publications

References 60 publications

Protection Activity of 1,4-Naphthoquinones in Rotenone-Induced Models of Neurotoxicity

Protection Activity of 1,4-Naphthoquinones in Rotenone-Induced Models of Neurotoxicity

Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling

Differences in epithelial-mesenchymal-transition in paraquat-induced pulmonary fibrosis in BALB/C and BALB/C (nu/nu) nude mice

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