Facilitation of Discriminated Rearing-Avoidance in Rats with Hippocampal Lesions

Saito, Satoshi; Ohki, Yuji

doi:10.2466/pms.1980.50.1.56

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…An interpretational difficulty of the above study is that the hippocampus is not necessary for learning of the active-avoidance task; in fact, hippocampal lesions or NMDA-receptor antagonists can facilitate active-or passive-avoidance learning, respectively (Mondadori et al 1989, Nadel 1968, Ohki 1982, Shimai & Ohki 1980. Thus increases observed in perforant-path responses that parallel learning may reflect ancillary learning of other aspects of the CS, such as context .…”

Section: Does Learning Produce Ltp-like Changes?mentioning

confidence: 93%

Long-Term Potentiation and Learning

Martinez

Derrick

1996

Annu. Rev. Psychol.

184

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Long-term potentiation (LTP), a relatively long-lived increase in synaptic strength, remains the mot popular model for the cellular process that may underlie information storage within neural systems. The strongest arguments for a role of LTP in memory are theoretical and involve Hebb's Postulate, Marr's theory of hippocampal function, and neural network theory. Considering LTP research as a whole, few studies have addressed the essential question: Is LTP a process involved in learning and memory? The present manuscript reviews research that attempts to link LTP with learning and memory, focusing on studies utilizing electrophysiological, pharmacological, and molecular biological methodologies. Most evidence firmly supports a role for LTP in learning memory. However, an unequivocal experimental demonstration of a contribution of LTP to memory is hampered by our lack of knowledge of the biological basis of memory and of the ways in which memories are represented in ensembles of neurons, the existence of a variety of cellular forms of LTP, and the likely resistance of distributed memory stores to degradation by treatments that incompletely disrupt LTP.

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Section: Does Learning Produce Ltp-like Changes?mentioning

confidence: 93%

Long-Term Potentiation and Learning

Martinez

Derrick

1996

Annu. Rev. Psychol.

184

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“…Hippocumpal Lesions: Facilitation of' Avoidance Beliavior Shimai and Ohki (1980) state that because of the paucity of variation in situations used in avoidance conditioning with the rat, it is difficult to find conclusive support for any hypothesis regarding the effects of hippocampal lesions upon avoidance conditioning. For example, they mention that some authors (Lovely, 1975;Schmaltz & Giulian, 1972) have found that hippocampal lesions facilitate the performance of two-way active escape and lever-press avoidance tasks, in the rat, while the same lesions cause an impairment in passive avoidance and one-way avoidance tasks (de Castro & Hall, 1975;Klein, Murphy, & Freeman, 1975).…”

mentioning

confidence: 99%

“…For example, they mention that some authors (Lovely, 1975;Schmaltz & Giulian, 1972) have found that hippocampal lesions facilitate the performance of two-way active escape and lever-press avoidance tasks, in the rat, while the same lesions cause an impairment in passive avoidance and one-way avoidance tasks (de Castro & Hall, 1975;Klein, Murphy, & Freeman, 1975). In order to investigate the nature of hippocampal function, Shimai and Ohki (1980) studied the effects of bilateral hippocampal lesions upon a discriminated, rearing avoidance task, in the rat.…”

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confidence: 99%

The Behavioral Effects of Lesions of the Hippocampus: A Review

Chozick¹

1983

International Journal of Neuroscience

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Activity of rabbit neocortex and hippocampus neurons in orientational-investigative behavior and freezing

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Vanetsian

2008

Neurosci Behav Physi

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Autocorrelation histograms were used to study the nature of spike activity in neurons recorded bilaterally from the visual and parietal areas of the cortex and hippocampal field CA1 in rabbits in free behavior during exposure to emotionally significant stimuli. Active movement orientational-investigative reactions to stimuli were associated with grouping of discharges and periodicity in the spike activity of most neurons in the cortex and hippocampus, this being dominated by the theta frequency (predominantly 4-5 Hz in the cortex and 4-5 and 6-7 Hz in the hippocampus). As compared with active movement reactions, freezing in response to stimulation was associated with increased numbers of neurons with uniform discharge distributions, while the spike activity of neurons with discharge periodicity showed increases in the intensity of the delta frequency (predominantly from 2 to 4 Hz), while theta intensity decreased. The number of neurons with periodic frequency in the delta range was greater in freezing than in the baseline state of calmly sitting rabbits.

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Facilitation of Discriminated Rearing-Avoidance in Rats with Hippocampal Lesions

Cited by 7 publications

References 11 publications

Long-Term Potentiation and Learning

Long-Term Potentiation and Learning

The Behavioral Effects of Lesions of the Hippocampus: A Review

Activity of rabbit neocortex and hippocampus neurons in orientational-investigative behavior and freezing

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