Facilitation of L-Type Ca<sup>2+</sup>Channels in Dendritic Spines by Activation of β<sub>2</sub>Adrenergic Receptors

Hoogland, Tycho M.; Saggau, Peter

doi:10.1523/jneurosci.1677-04.2004

Cited by 103 publications

(107 citation statements)

References 84 publications

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“…To identify steps in signal transduction downstream of GAB-A B R and mGluRIII, we imaged calcium spikes in the presence of antagonists of PKA or PKC, because these kinases are tar- gets of GABA B R and mGluRIII (Olianas and Onali, 1999;Shen and Slaughter, 1999;Catsicas and Mobbs, 2001;Evans et al, 2001;Couve et al, 2002;Martin et al, 2004) and modulate the properties of calcium and potassium channels (Taylor et al, 2000;Park et al, 2003;Zhang et al, 2003;Hoogland and Saggau, 2004;Mathie, 2007). PKC and PKA could inhibit tandem pore domain potassium channels that set the membrane potential or engage lowvoltage-and high-voltage-activated calcium currents and potassium currents involved in generating calcium spikes in these neurons (Gu and Spitzer, 1993).…”

Section: Gaba B and Mgluriii Activate Pka And Pkcmentioning

confidence: 99%

Embryonically Expressed GABA and Glutamate Drive Electrical Activity Regulating Neurotransmitter Specification

Root

Velazquez-Ulloa²,

Monsalve³

et al. 2008

J. Neurosci.

106

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Neurotransmitter signaling in the mature nervous system is well understood, but the functions of transmitters in the immature nervous system are less clear. Although transmitters released during embryogenesis regulate neuronal proliferation and migration, little is known about their role in regulating early neuronal differentiation. Here, we show that GABA and glutamate drive calcium-dependent embryonic electrical activity that regulates transmitter specification. The number of neurons expressing different transmitters changes when GABA or glutamate signaling is blocked chronically, either using morpholinos to knock down transmitter-synthetic enzymes or applying pharmacological receptor antagonists during a sensitive period of development. We find that calcium spikes are triggered by metabotropic GABA and glutamate receptors, which engage protein kinases A and C. The results reveal a novel role for embryonically expressed neurotransmitters.

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Section: Gaba B and Mgluriii Activate Pka And Pkcmentioning

confidence: 99%

Embryonically Expressed GABA and Glutamate Drive Electrical Activity Regulating Neurotransmitter Specification

Root

Velazquez-Ulloa²,

Monsalve³

et al. 2008

J. Neurosci.

106

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“…Although there is a considerable literature on the role of ␤1AR activation in modulating synaptic activity, much less is known about the role of NA acting via ␤2AR receptors. Activation of ␤2R in CA1 pyramidal cells has been shown to increase L-type calcium channel activity (Hoogland and Saggau, 2004), but what the functional consequences are of NA acting via ␤2AR on this subset of interneurons remains to be determined.…”

Section: ␤2ar Expression Predominates In Cholecystokinin-containing Imentioning

confidence: 99%

β‐adrenergic receptors are differentially expressed in distinct interneuron subtypes in the rat hippocampus

Cox

Racca

LeBeau

2008

J of Comparative Neurology

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Noradrenaline (NA) acting via ␤-adrenergic receptors (␤ARs) plays an important role in the modulation of memory in the hippocampus. ␤ARs have been shown to be expressed in principal cells, but their distribution across different interneuron classes is unknown. We have used specific interneuron markers including calcium binding proteins (parvalbumin, calbindin, and calretinin) and neuropeptides (somatostatin, neuropeptide Y, and cholecystokinin) together with either ␤1AR or ␤2AR to determine the distribution of these receptors in all major subfields of the hippocampus. We found that ␤1AR-expressing interneurons were more prevalent in the CA3 and CA1 regions of the hippocampus than in the dentate gyrus, where they were relatively sparse. ␤2AR-expressing interneurons were more uniformly distributed between all three regions of the hippocampus. A high proportion of neuropeptide Y-containing interneurons in the dentate gyrus co-expressed ␤2AR. ␤1AR labeling was common in interneurons expressing somatostatin and parvalbumin in the CA3 and CA1 regions, particularly in the stratum oriens of these regions. ␤2AR labeling was more likely to be found than ␤1AR labeling in cholecystokinin-expressing interneurons. In contrast, calretinin-containing interneurons were virtually devoid of ␤1AR or ␤2AR labeling. These regional and interneuron type-specific differences suggest functionally distinct roles for NA in modulating hippocampal activity via activation of ␤ARs.

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“…Therefore, it is likely that the role of L-type channels in supporting fast Ca 2ϩ signals has been underestimated thus far (Yasuda et al, 2003;Hoogland and Saggau, 2004) because of the ineffectiveness of dihydropyridines in contrasting L-type channel activation on rapid time scales. Our experiments show that L-type channels produce most of SLINC and of the Ca 2ϩ influx at depolarized potentials.…”

Section: Identity Of the Slowly Inactivating Calcium Currentsmentioning

confidence: 99%

T-Type and L-Type Ca²⁺Conductances Define and Encode the Bimodal Firing Pattern of Vestibulocerebellar Unipolar Brush Cells

Diana¹,

Otsu²,

Maton³

et al. 2007

J. Neurosci.

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Cerebellar unipolar brush cells (UBCs) are glutamatergic interneurons that receive direct input from vestibular afferents in the form of a unique excitatory synapse on their dendritic brush. UBCs constitute independent relay lines for vestibular signals, and their inherent properties most likely determine how vestibular activity is encoded by the cerebellar cortex. We now demonstrate that UBCs are bimodal cells; they can either fire high-frequency bursts of action potentials when stimulated from hyperpolarized potentials or discharge tonically during sustained depolarizations. The two functional states can be triggered by physiological-like activity of the excitatory input and are encoded by distinct Ca 2ϩ -signaling systems. By combining complementary strategies, consisting of molecular and electrophysiological analysis and of ultrafast acousto-optical deflector-based two-photon imaging, we unraveled the identity and the subcellular localization of the Ca 2ϩ conductances activating in each mode. Fast inactivating T-type Ca 2ϩ channels produce low-threshold spikes, which trigger the high-frequency bursts and generate powerful Ca 2ϩ transients in the brush and, to a much lesser extent, in the soma. The tonic firing mode is encoded by a signalization system principally composed of L-type channels. Ca 2ϩ influx during tonic firing produces a linear representation of the spike rate of the cell in the form of a widespread and sustained Ca 2ϩ concentration increase and regulates cellular excitability via BK potassium channels. The bimodal firing pattern of UBCs may underlie different coding strategies of the vestibular input by the cerebellum, thus likely increasing the computational power of this structure.

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Facilitation of L-Type Ca²⁺Channels in Dendritic Spines by Activation of β₂Adrenergic Receptors

Cited by 103 publications

References 84 publications

Embryonically Expressed GABA and Glutamate Drive Electrical Activity Regulating Neurotransmitter Specification

Embryonically Expressed GABA and Glutamate Drive Electrical Activity Regulating Neurotransmitter Specification

β‐adrenergic receptors are differentially expressed in distinct interneuron subtypes in the rat hippocampus

T-Type and L-Type Ca²⁺Conductances Define and Encode the Bimodal Firing Pattern of Vestibulocerebellar Unipolar Brush Cells

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Facilitation of L-Type Ca2+Channels in Dendritic Spines by Activation of β2Adrenergic Receptors

Cited by 103 publications

References 84 publications

Embryonically Expressed GABA and Glutamate Drive Electrical Activity Regulating Neurotransmitter Specification

Embryonically Expressed GABA and Glutamate Drive Electrical Activity Regulating Neurotransmitter Specification

β‐adrenergic receptors are differentially expressed in distinct interneuron subtypes in the rat hippocampus

T-Type and L-Type Ca2+Conductances Define and Encode the Bimodal Firing Pattern of Vestibulocerebellar Unipolar Brush Cells

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Product

Resources

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Facilitation of L-Type Ca²⁺Channels in Dendritic Spines by Activation of β₂Adrenergic Receptors

T-Type and L-Type Ca²⁺Conductances Define and Encode the Bimodal Firing Pattern of Vestibulocerebellar Unipolar Brush Cells