Facilitation of picture naming after repetitive transcranial magnetic stimulation

Mottaghy, Felix M.; Hungs, Marcel; Brügmann, M.; Sparing, Roland; Boroojerdi, Babak; Foltys, Henrik; Huber, Walter; Töpper, Rudolf

doi:10.1212/wnl.53.8.1806

Cited by 143 publications

(77 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the motor system, this is seen as a change in the size of MEPs in the targeted muscle. In non-motor regions, rTMS can result in changes in behavioral measures such as task performance or reaction times (e.g., Mottaghy et al, 1999;Ahn et al, 2013). Stimulation can either enhance or inhibit local neural activity (Stefan et al, 2000;Huang et al, 2005).…”

Section: Transcranial Magnetic Stimulationmentioning

confidence: 99%

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Sale¹,

Mattingley²,

Zalesky³

et al. 2015

Neuroscience & Biobehavioral Reviews

127

View full text Add to dashboard Cite

show abstract

Section: Transcranial Magnetic Stimulationmentioning

confidence: 99%

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Sale¹,

Mattingley²,

Zalesky³

et al. 2015

Neuroscience & Biobehavioral Reviews

127

View full text Add to dashboard Cite

show abstract

“…van der Linde, Bastiaanse, & Gilbers, 1998; Nickels, 1997;Goodglass & Kaplan, 1983). Functional brain imaging studies have suggested the importance of the left inferior parietal lobe in encoding and retrieval of episodic information (e.g., Mottaghy et al, 1999), in repeating number sequences (Cowell, Egan, Code, Harasty, & Watson, 2000), and in spatial coding of letters ( Jordan, Heinze, Lutz, Kanowski, & Jancke, 2001). Furthermore, recent functional brain imaging studies have strongly suggested that the left inferior parietal lobe has a crucial role in verbal working memory, namely phonological storage and encoding (Becker, MacAndrew, & Fiez, 1999;Paulesu, Frith, & Frackowiak, 1993).…”

Section: Training-specific Changes In Brain Responsesmentioning

confidence: 99%

Adult Brain Plasticity Elicited by Anomia Treatment

Cornelissen¹,

Laine

Tarkiainen³

et al. 2003

Journal of Cognitive Neuroscience

151

View full text Add to dashboard Cite

Abstract& We describe a study where a specific treatment method for word-finding difficulty (so-called contextual priming technique, which combines massive repetition priming with semantic priming) was applied with three chronic left hemispheredamaged aphasics. Both before and after treatment, which focused on naming of a series of pictures, naming-related brain activity was measured by magnetoencephalography (MEG). Due to its excellent temporal resolution and good spatial resolution, we were able to track treatment-induced changes in cortical activity. All three subjects showed improved naming of the trained items. In all subjects, a single source area, located in the left inferior parietal lobe, close to the lesioned area, displayed statistically significant training-induced changes. This effect was of long latency as it started 300 -600 msec after picture presentation. The change in activation was specific to training, as it could not be accounted for by variation of cortical dynamics associated with increased proportion of correct answers. Our interpretation is that the training effect reflects more effective phonological encoding and storage of the trained items through the engagement of a left hemispheric word-learning system. This is in line with recent functional imaging studies, which have linked left inferior parietal lobe activity to the phonological storage component of the verbal working memory, as well as with theoretical arguments stating that the primary role of the phonological loop is to acquire new words. Finally, the MEG results showed no evidence of increased right hemisphere participation following training, supporting the view that restoration of language-related networks in the damaged left hemisphere is crucial for anomia recovery. &

show abstract

“…Other studies have utilised transcranial magnetic stimulation (TMS) to transiently disrupt neural processing, thereby effectuating a quantifiable change in behavioural performance when it is applied to an area functionally involved in the task at question (Pascual-Leone et al, 2000). These studies have contributed to the understanding of the functional relevance of language-related brain areas to the behavioural execution of various language tasks (Andoh et al, 2006;Devlin et al, 2003;Mottaghy et al, 1999Mottaghy et al, , 2006Naeser et al, 2005;Nixon et al, 2004;Sakai et al, 2002;Shapiro et al, 2001). However, only few of these TMS studies employed the advantage of event-related TMS to track the exact time point of functionally relevant neural activity during language production.…”

Section: Introductionmentioning

confidence: 99%

The temporal characteristics of functional activation in Broca's area during overt picture naming

Schuhmann

Schiller

Goebel

et al. 2009

Cortex

View full text Add to dashboard Cite

Picture namingBroca's area Language production Speech production a b s t r a c tThe opercular and triangular sections of the inferior frontal gyrus, also known as Broca's area, have been shown to be involved in various language tasks. In the current study we investigated both the functional role, as well as the precise temporal involvement of Broca's area during picture naming. We applied online event-related transcranial magnetic stimulation (TMS) to Broca's area at five different time points after picture presentation, aiming to cover the complete language production process. Applying real TMS at 300 msec after picture presentation led to an increase in picture naming latency, whereas sham stimulation and real stimulation at earlier and later time windows did not result in any changes in reaction time (RT). Our methodological approach enabled us to get insight into the temporal characteristics of the involvement of this brain area during picture naming.Making use of this information and directly relating it to psycholinguistic models, we conclude that Broca's area may be involved in the process of syllabification during overt speech production. ª 2008 Elsevier Srl. All rights reserved. IntroductionOur ability to communicate and comprehend verbal language represents one of the most crucial and complex human cognitive skills. By employing single case lesion studies, Broca (1861) and Wernicke (1874) were pioneers in the attempt to directly relate different aspects of language processing to the proper functioning of distinct regions of the cerebral cortex. With the advent of modern functional brain imaging techniques, a systematic non-invasive investigation of the neural correlates of language also became available in healthy volunteers. Until today, a vast amount of studies have continued to reveal detailed insights into the exact functional neuroanatomy underlying speech production using electrophysiological [magnetoencephalography (MEG) (Salmelin, 2007) and electroencephalography (EEG) (Schiller et al., 2003;Schmitt et al., 2000)] and metabolic brain imaging techniques (see for example Gernsbacher and Kaschak, 2003;Binder et al., 1997). Other studies have utilised transcranial magnetic stimulation (TMS) to transiently disrupt neural processing, thereby effectuating a quantifiable change in behavioural performance when it is applied to an area functionally involved in the task at question (Pascual-Leone et al., 2000).

show abstract

Facilitation of picture naming after repetitive transcranial magnetic stimulation

Abstract: Repetitive transcranial magnetic stimulation over Wernicke's area leads to a brief facilitation of picture naming by shortening linguistic processing time.

Cited by 143 publications

References 33 publications

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Adult Brain Plasticity Elicited by Anomia Treatment

The temporal characteristics of functional activation in Broca's area during overt picture naming

Contact Info

Product

Resources

About