Facilitation of the HPA Axis to a Novel Acute Stress Following Chronic Stress Exposure Modulates Histone Acetylation and the ERK/MAPK Pathway in the Dentate Gyrus of Male Rats

Ferland, Chantelle L.; Harris, Erin P.; Lam, Mai T.; Schrader, Laura A.

doi:10.1210/en.2013-1918

Cited by 30 publications

(30 citation statements)

References 48 publications

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“…Lack of responsivity has physiological underpinnings. Exposure to unremitting stress results in known suppression of primary sensory pathways, deficits in multi-modal sensory integration (Girotti et al, 2006) and dampened neural activity in the dyntate gyrus of the hippocampus, perhaps due to large increases in HSP70 expression (Filipovic, Zlatkovic, Gass, & Inta, 2013), activation of extracellular signalregulated kinase (ERK) or decreased histone acetylation (Ferland, Harris, Lam, & Schrader, 2014). With chronic stress exposure changes also occur to the prefrontal cortex, which alter one's ability to selectively attend to stimuli (Arnsten, 2009).…”

Section: Discussionmentioning

confidence: 99%

Higher chronic psychological stress is associated with blunted affective responses to strenuous resistance exercise: RPE, pleasure, pain

Stults‐Kolehmainen

Ciccolo

et al. 2016

Psychology of Sport and Exercise

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Section: Discussionmentioning

confidence: 99%

Higher chronic psychological stress is associated with blunted affective responses to strenuous resistance exercise: RPE, pleasure, pain

Stults‐Kolehmainen

Ciccolo

et al. 2016

Psychology of Sport and Exercise

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“…GRF1 may regulate the HPA axis through its known ability to couple NMDA and calcium-permeable glutamate receptors to both the Erk, p38 Map kinases, since various stress paradigms have been observed to alter the activities of these kinases (Cole et al, 2000; Ferland et al, 2014; Revest et al, 2005). However, to date these findings are just correlative and they were detected in adult males.…”

Section: Discussionmentioning

confidence: 99%

RasGRF1 regulates the hypothalamic–pituitary–adrenal axis specifically in early-adolescent female mice

Uzturk

Jin

Rubin

et al. 2015

Journal of Endocrinology

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Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the induction and prolongation of a variety of psychiatric disorders. As such, much effort has been made to understand the molecular mechanisms involved in its control. However, the vast majority of the studies on the HPA axis have used adult animals, and among these the majority has used males. Here we show that in knockout mice lacking the guanine nucleotide exchange factor, RasGRF1, habituation to 30 minutes a day of restraint stress is markedly accelerated, such that these mice do not display elevated corticosterone levels or enhanced locomotion after 7 days of stress exposure, like WT mice do. Strikingly, this phenotype is present in early-adolescent female RasGRF1 knockout mice, but not in their early-adolescent male, mid-adolescent female, adult female or adult male counterparts. Moreover, not only is there a clear response to restraint stress in early-adolescent female RasGRF1 knockout mice, their response after 1, 3, and 5 exposures is magnified ~3-fold compared to WT mice. These findings imply that distinct mechanisms exist to regulate the HPA axis in early-adolescent females that involves RasGRF1. A full understanding of how RasGRF1 controls the HPA axis response to stress may be required to design effective strategies to combat stress-associated psychiatric disorders initiated in young females.

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“…43,44) The HPA sensitization after chronic stress including SART stress may be associated with a reduced efficacy of negative glucocorticoid feedback 45) and involve neurochemical alterations including extracellular signal-regulated kinase (ERK) activation in the hippocampus. 46) In conclusion, our data suggest that SART stress enhances the acute restraint stress-induced, β 3 -adrenocepor-dependent thermogenesis in mice, which is independent of endogenous prostanoids, glucocortigoids or increased anxiety levels.…”

Section: Discussionmentioning

confidence: 58%

Repeated Cold Stress Enhances the Acute Restraint Stress-Induced Hyperthermia in Mice

Miyamoto

Funakami

Kawashita

et al. 2017

Biological & Pharmaceutical Bulletin

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The rodents exposed to repeated cold stress according to a specific schedule, known as specific alternation of rhythm in temperature (SART), exhibit autonomic imbalance, and is now used as an experimental model of fibromyalgia. To explore the susceptibility of SART-stressed animals to novel acute stress, we tested whether exposure of mice to SART stress for 1 week alters the extent of acute restraint stress-induced hyperthermia. Mice were subjected to 7-d SART stress sessions; i.e., the mice were alternately exposed to 24 and 4°C at 1-h intervals during the daytime (09:00-16:00) and kept at 4°C overnight (16:00-09:00). SARTstressed and unstressed mice were exposed to acute restraint stress for 20-60 min, during which rectal temperature was monitored. Serum corticosterone levels were measured before and after 60-min exposure to restraint stress. SART stress itself did not alter the body temperature or serum corticosterone levels in mice. Acute restraint stress increased the body temperature and serum corticosterone levels, both responses being greater in SART-stressed mice than unstressed mice. The enhanced hyperthermic responses to acute restraint stress in SART-stressed mice were significantly attenuated by SR59230A, a β 3 adrenoceptor antagonist, but unaffected by diazepam, an anxiolytic, mifepristone, a glucocorticoid receptor antagonist, or indomethacin, a cyclooxygenase inhibitor. These results suggest that SART stress enhances the susceptibility of mice to acute restraint stress, characterized by increased hyperthermia and corticosterone secretion, and that the increased hyperthermic responses to acute stress might involve accelerated activation of sympathetic β 3 adrenoceptors, known to regulate non-shivering thermogenesis in the brown adipose tissue.

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Facilitation of the HPA Axis to a Novel Acute Stress Following Chronic Stress Exposure Modulates Histone Acetylation and the ERK/MAPK Pathway in the Dentate Gyrus of Male Rats

Cited by 30 publications

References 48 publications

Higher chronic psychological stress is associated with blunted affective responses to strenuous resistance exercise: RPE, pleasure, pain

Higher chronic psychological stress is associated with blunted affective responses to strenuous resistance exercise: RPE, pleasure, pain

RasGRF1 regulates the hypothalamic–pituitary–adrenal axis specifically in early-adolescent female mice

Repeated Cold Stress Enhances the Acute Restraint Stress-Induced Hyperthermia in Mice

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