Introduction:
Antiretroviral Therapy has markedly improved survival of people living with human Immune virus. Yet, the full potential benefits of the therapy depend on understanding of predictors of mortality among PLWHA. The aim of this study was to assess predictors of mortality among adult PLWHA in Jimma Zone Public Hospitals.
Methods
A retrospective cohort study was conducted among 676 adult PLWHA who enrolled to ART clinic from September 1st, 2012 - August 30, 2016. Multivariable Cox Regression analysis was used to identify predictors of mortality using 95% confidence interval (CI) and at P value ≤ 0.05 cut of point.
Results
The total person-time contributed was 28,209 person-months with an overall mortality incidence rate of 11 per 1000 person-months observation. The cumulative mortality incidence among females over the study period was 16.8% (64/382). The predictors of mortality were found severe Undernourishment (AHR: 3.7; 95% CI: 1.6, 6.7) and moderate malnutrition (AHR: 2.5; 95% CI: 1.7, 7.5) at base line, younger age (AHR:2.1; 95% CI: 1.7, 3.3), female (AHR: 2.8; 95% CI: 2.1,4.6), single (AHR: 2.6; 95% CI: 1.8, 3.8), divorced (AHR: 2.4; 95% CI: 1.3,3.9) Illiterate (AHR: 2.5; 95% CI: 1.9, 4.8), lack of disclosure (AHR: 3.6; 95%: 1.7, 9.5), WHO clinical stage IV (AHR: 3.7; 95% CI: 1.7, 5.3), seeking treatment out of catchment area (AHR:3.6; 95% CI: 1.5,5.4), rural residence (AHR:2.1; 95% CI:1.4, 3.3), and immunological failure (AHR:1.7; 95% CI: 1.3, 2.7).
Conclusions
Poor nutritional status at baseline, advanced HIV disease, occurrence of treatment failure, female sex, substance use disorders, lack of social support, immunological failures, clinical failures, and younger age, low level of education and poor physical access to healthcare facility were found to be important predictors of mortality. Intervening, those factors as routine and part of “appointment spacing model care” can improve survival of PLWHA.