Individuals who experience mental disorders certainly experience changes, both changes from the cognitive, affective, social, and spiritual dimensions. Spirituality is closely related to mental health, which affects psychological strength and well-being, so that it will increase acceptance of the problems faced. Spirituality therapy approaches must be carried out in managing care, which is integral to nursing services, including bio, psycho, socio, and spiritual. This review aims to collect and analyze articles related to therapy with a spiritual approach in dealing with mental health disorders, which is a spiritual treatment that is an essential aspect in the management of mental disorders, therefore it is necessary to conduct a study to determine the effect of spiritual therapy in the management of mental disorders. The research design used 6 (six) article databases as search results, such as Pub Med, Google Scholar, Crossref, and Scopus, with the keywords Mental illness OR mental disorder AND spirituality OR spiritual therapies. The criteria for the articles used are those published in 2016 -2021. This research found that spiritual therapy is needed to manage patients with mental disorders. This is because the Spiritual Therapy approach helps encourage others to increase positive emotions, improving mental health and reducing anxiety and depression in patients with mental disorders.