First, do no harm. Clearly, this is one of the tenets of medicine and the allied health professions and is expressed in one of our core ethical principles: nonmaleficence. If we see a patient in pain and we are unable to relieve it, then, at the very least, we should not contribute further to that patient's suffering. This standard has direct ethical implications in the practice of pain management, since the medications used in this endeavor are, in large part, potentially addictive and habit-forming substances [1][2][3].
Pendulum Swings in Pain ManagementOpioids have been available in one form or another for thousands of years, and yet they have been avoided, and pain has gone undertreated [4]. The fear of creating or worsening addiction has been one of the main reasons for this irrational avoidance of an effective but admittedly "blunt instrument" in the treatment of pain. For many decades, the exaggerated fear that exposure to these medications brought about addiction-and the intent to prevent that consequence-amounted to nonmaleficence gone awry. Paired with, perhaps, an underestimation of the benefits of simply relieving pain (as opposed to being able to correct its underlying etiology), the need to avoid addiction at all costs has led to tremendous, unnecessary patient suffering.A paradigm shift that has affected the way opioids are used, however, has been occurring for the past 20 years in the U.S. and several other countries. Fueled by the observation that people with cancer seem to be able to take these medications and enjoy good outcomes (analgesia, enhanced activity, tolerable adverse effects, and minimal or no aberrant drug-taking) the thinking about opioid use changed. Implicit in the change is the obvious assertion that having cancer itself did not bestow protection against addiction [5][6][7].As this revolution occurred, the clinical practice and rhetoric of aggressive pain management moved faster than the clinical trials, and, when groups of patients who were considerably more diverse than those with cancer were tested, the results were mixed. Unfortunately, the claims of diminished harm from drug use tended to trivialize addiction to the point where it was commonplace to hear that the risk of taking the medications was virtually nonexistent [8]. Thus, beneficence dictated that opioids could not be ethically withheld in many clinical circumstances. Under this new model, the worst thing a physician could do-ethically speaking-was to deny