Facteurs associés à la dissociation immunovirologique chez les patients infectés par le VIH-1 sous traitement antirétroviral hautement actif au Centre de Traitement Ambulatoire (CTA) de Dakar

Kà, Daye; Manga, N.M.; Ngom-Guéye, Ndéye Fatou; Ndiaga, Diop; Diop, Moustapha; Cisse-Diallo, Viviane Marie Pierre; Diallo-Mbaye, Khardiata; Lakhe, Ndèye Aïssatou; Fortes-Déguénonvo, L.; Ndour, Cheikh Tidiane; Diop-Nyafouna, Sylvie A; Seydi, Moussa

doi:10.11604/pamj.2017.27.16.9811

Cited by 3 publications

(5 citation statements)

References 19 publications

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“…20 This implies that these participants are at risk of developing an advanced disease based on the WHO definition for advanced HIV disease. This finding, however, differs from that obtained in Benin, 68.8% 24 and in Togo 73.8%. 14 The differences may be due to the fact that these studies were done in 2004 and 2011, respectively, when the HIV/AIDS treatment initiation rates were even lower.…”

Section: Discussioncontrasting

confidence: 94%

Epidemiology of Opportunistic Infections in HIV Infected Patients on Treatment in Accredited HIV Treatment Centers in Cameroon

Kouanfack

Billong

et al. 2019

Int J MCH AIDS

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Background: The African continent accounts for over 70% of people infected with Human Immunodeficiency Virus (HIV). The HIV sero-prevalence rate in Africa is estimated at 4.3%. In developed countries, such as France, pneumocystis is indicative of AIDS in 30% of patients; however, in Africa, pulmonary tuberculosis (TB) is the most-documented opportunistic infection (OI) and the leading cause of death in HIV-infected patients. In 2016, Cameroon had 32,000 new cases of OI and 29,000 deaths as a result of these infections. However, there is little existing data on the epidemiological profile of OIs in Cameroon, which is why we conducted this study in accredited HIV treatment centers and care/ treatment units in the two cities of Douala and Yaounde, Cameroon. Methods: This was a retrospective descriptive and analytical study carried out in 12 accredited HIV treatment centers in the cities of Yaound

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Section: Discussioncontrasting

confidence: 94%

Epidemiology of Opportunistic Infections in HIV Infected Patients on Treatment in Accredited HIV Treatment Centers in Cameroon

Kouanfack

Billong

et al. 2019

Int J MCH AIDS

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“…Previous studies have shown that the absence or cessation of ARV treatment can lead to a deterioration in clinical condition, a drop in immunity and an increase in viral load in patients who are off treatment. This contributes to an increase in morbidity and mortality related to HIV infection and to the development of resistance to antiretroviral drugs (ARVs) [6,7].…”

Section: Ofmentioning

confidence: 99%

Incidence and Predictors of Loss to Follow Up among Patients Living with HIV under Dolutegravir in Bunia, Democratic Republic of Congo: A Prospective Cohort Study

Buju¹,

Akilimali

Kamangu

et al. 2022

IJERPH

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This study aimed to examine the incidence and predictors of loss to follow up (LTFU) in the context of ongoing atrocities caused by armed conflict, where HIV treatment programs and HIV-infected patients may face unique challenges in terms of ART adherence and retention in care. We conducted an observational prospective cohort study of 468 patients living with HIV (PLWHIV) under dolutegravir (DTG) in all health facilities in Bunia between July 2019 and July 2021. Kaplan–Meier plots were used to determine the probability of LTFU as a function of time as inclusive of the cohort. The main outcome variable was LTFU, defined as not taking an ART refill for a period of 3 months or longer from the last attendance for refill, and not yet classified as ‘dead’ or ‘transferred-out.’ The log-rank test was used to compare survival curves based on predictors. Cox proportional hazard modeling was used to measure predictors of LTFU from the baseline until 31 July 2021 (the endpoint). A total of 3435.22 person-months (p-m) were involved in follow up, with an overall incidence rate of 33.48 LTFU per 1000 p-m. Patients who had less experience with ART at enrolment and the ethnically Sudanese, had a higher hazard of being LTFU compared to their reference groups. This study reports a high LTFU rate in this conflict setting. An ART program in such a setting should pay more attention to naive patients and other particularly vulnerable patients such as Sudanese during the pre-ART phase. The study implies the implementation of innovative strategies to address this high risk of being LTFU, reducing either the cost or the distance to the health facility.

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“…However, Ka D et al in Senegal observed a male predominance of IVD (29.7%) [13]. This female predominance could be explained by the fact that women more frequently attend healthcare services and, on the other hand, constitute a vulnerable group [13].…”

Section: Discussionmentioning

confidence: 96%

“…Male gender, CD4+ T-Cell count (<200 cells/mm 3 ), Pruritus was associated with IVD. or equal to 43 years, initial CD4 count < 100 cells/mm 3 , and male gender were associated with IVD [13]. These results may be explained by the fact that some patients were initiated on ART late with a VL > 100,000 copies/mL, severe immunosuppression (CD4 < 200), which are among the factors influencing the immunovirological response in PLHIV under ART [28].…”

Section: Discussionmentioning

confidence: 99%

“…These factors are related to late diagnosis, low CD4+ T-cell count at initiation, advanced age, and male gender [8] [9] [10]. In addition, other biological and clinical factors such as immune activation [11], the number of CD4+ T-cells at the initiation of treatment [12], co-infection, poor adherence [13], and the treatment regimen [2] [7] [14] have been associated with the occurrence of IVD.…”

Section: Introductionmentioning

confidence: 99%

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Immunovirological Discordance and Associated Factors among People Living with HIV under Antiretroviral Treatment at H&#244;pital de Jour de Donka, Guinea

Diallo,

Kaba,

Delicat

et al. 2024

OJMM

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The antiretroviral treatment (ART) has significantly reduced the number of new HIV/AIDS infections and related deaths. However, cases of immunovirological discordance (IVD) are found in various locations. The objective of this study was to determine the profile of People living with HIV (PLHIV) with IVD and to identify associated factors. We conducted a cross-sectional study based on the records of PLHIV under ART for at least 6 months, followed at Hôpital de Jour Donka from 2015 to 2017, and having both viral load (CV) and CD4+ T-cell count. Prevalence of IVD was 34.57%, with 23.87% for immunological discordance (ID) and 10.7% for virological discordance (VD). Females were predominant (66.26%), and male gender influenced IVD with a statistically significant difference (p = 0.006) and was associated with VD (p = 0.007). The average age was 38.77 ± 11.30 years. PLHIV were classified at WHO stages 3 and 4 (86.01%). The median initial haemoglobin level was 11.5 g/L [3.2 -12]. The mean initial CD4+ T-cell count was 272.84 cells/mm 3 ± 201.6. The median initial viral load (VL) was 147,337 copies/mL [1092 -31,675,000]. The initial CD4+ T-cell count < 200 cells/mm 3

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Facteurs associés à la dissociation immunovirologique chez les patients infectés par le VIH-1 sous traitement antirétroviral hautement actif au Centre de Traitement Ambulatoire (CTA) de Dakar

Cited by 3 publications

References 19 publications

Epidemiology of Opportunistic Infections in HIV Infected Patients on Treatment in Accredited HIV Treatment Centers in Cameroon

Epidemiology of Opportunistic Infections in HIV Infected Patients on Treatment in Accredited HIV Treatment Centers in Cameroon

Incidence and Predictors of Loss to Follow Up among Patients Living with HIV under Dolutegravir in Bunia, Democratic Republic of Congo: A Prospective Cohort Study

Immunovirological Discordance and Associated Factors among People Living with HIV under Antiretroviral Treatment at H&#244;pital de Jour de Donka, Guinea

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Facteurs associés à la dissociation immunovirologique chez les patients infectés par le VIH-1 sous traitement antirétroviral hautement actif au Centre de Traitement Ambulatoire (CTA) de Dakar

Cited by 3 publications

References 19 publications

Epidemiology of Opportunistic Infections in HIV Infected Patients on Treatment in Accredited HIV Treatment Centers in Cameroon

Epidemiology of Opportunistic Infections in HIV Infected Patients on Treatment in Accredited HIV Treatment Centers in Cameroon

Incidence and Predictors of Loss to Follow Up among Patients Living with HIV under Dolutegravir in Bunia, Democratic Republic of Congo: A Prospective Cohort Study

Immunovirological Discordance and Associated Factors among People Living with HIV under Antiretroviral Treatment at H&amp;#244;pital de Jour de Donka, Guinea

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Immunovirological Discordance and Associated Factors among People Living with HIV under Antiretroviral Treatment at Hôpital de Jour de Donka, Guinea