Facteurs associés à la non observance thérapeutique des sujets adultes infectés par le VIH sous antirétroviraux dans un hôpital de référence à Douala

Essomba, Emmanuel Noel; Adiogo, Dieudonné; Koum, Danielle Christiane Kedy; Amang, Baudouin; Lehman, Léopold Gustave; Coppieters, Yves

doi:10.11604/pamj.2015.20.412.5678

Cited by 15 publications

(13 citation statements)

References 21 publications

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“…In the present study, half of participants were aged between 35 and 45 years. This is similar to some previous studies in which 49.2 and 27.5% aged between 30-44 and 35-44 years, respectively were found (Mbanya et al, 2002;Essomba et al, 2015). These results show that 35 to 45 years are the hardest hit ages as far as HIV infection is concerned in Cameroon.…”

Section: Discussionsupporting

confidence: 91%

“…In the present study, the majority of participants were female (70.8%). This result is in line with a previous study carried out in the Laquintinie Hospital in which 64.6% were women, with a sex ratio of 0.54 in favor of women (Ramjee and Daniels, 2013;Essomba et al, 2015). This feminization of the pandemics might be due to the biological, epidemiological and sociocultural factors that characterize women's vulnerability as far as HIV infection is concerned in sub-Saharan Africa.…”

Section: Discussionsupporting

confidence: 91%

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Serum protein electrophoresis as an added value for disease control among HIV patients in a hospital setting in Cameroon

Marceline¹,

Justin²,

Luther³

et al. 2018

J. AIDS HIV Res.

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In the resource-limited countries, CD4 count and viral load (VL) determination are not always systematic, due to the low follow-up coverage and/or limited access to optimal hospital facilities. The present study aimed at evaluating the clinical role of Serum Protein Electrophoresis (SPE) in HIV health care and disease control. An analytic study was conducted in a Cameroon reference's hospital, in HIV patients on antiretroviral treatment. Blood sample was collected to perform CD4 count, viral load, total proteins, and SPE through clinical capillary electrophoresis. SPE data were correlated to other results. ANOVA, Mann-Whitney test and Pearson's correlation were performed, at the threshold P<0.05. A total of 72 patients: 51 (70.8%) women and 21 (29.1%) men were included, with a mean age of 41.22±8.48 years. The electrophoretic profile showed that the majority of patients have hyperproteinemia (70.9%) and hyper-γ-globulinemia (89%). All the enrolled patients had low albumin/globulin ratio. A negative and significant correlation was observed between CD4 count and total proteins (r=-0.5, P<0.0001), and γglobulin (r=-0.6, P<0.0001). The correlation was positive and significant with the albumin/globulin ratio (r=0.6, P<0.0001). Patients with VL≥250 Cp/mL, had a high total proteins and different fractions of globulins, compared to those with VL<250 Cp/mL. The perturbation of CD4 count and VL were associated with SPE data variations, which better describes patient's clinical status. SPE could be combined to the existing analyses to improve AIDS health care.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Serum protein electrophoresis as an added value for disease control among HIV patients in a hospital setting in Cameroon

Marceline¹,

Justin²,

Luther³

et al. 2018

J. AIDS HIV Res.

View full text Add to dashboard Cite

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“…Three studies were published in French [116,137,149] and a fluent French speaker was utilized to extract the data and translate into English. The remaining studies were published in English.…”

Section: Resultsmentioning

confidence: 99%

Patient-reported barriers and facilitators to antiretroviral adherence in sub-Saharan Africa

Croome

Ahluwalia²,

Hughes³

et al. 2017

Aids

138

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Objective:The aim of this study was to identify the range and frequency of patient-reported barriers and facilitators to antiretroviral treatment (ART) adherence in sub-Saharan Africa (SSA).Design:Studies from 2005 to 2016 were identified by searching 10 electronic databases and through additional hand and web-searching.Methods:Inclusion criteria were HIV-positive adults taking ART based in any SSA country, qualitative study or quantitative survey and included at least one patient-reported barrier or facilitator to ART adherence. Exclusion criteria were only including data from treatment-naive patients initiating ART, only single-dose treatment, participants residing outside of SSA and reviews.Results:After screening 11 283 records, 154 studies (161 papers) were included in this review. Forty-three barriers and 30 facilitators were reported across 24 SSA countries. The most frequently identified barriers across studies were forgetting (n = 76), lack of access to adequate food (n = 72), stigma and discrimination (n = 68), side effects (n = 67) and being outside the house or travelling (n = 60). The most frequently identified facilitators across studies were social support (n = 60), reminders (n = 55), feeling better or healthier after taking ART (n = 35), disclosing their HIV status (n = 26) and having a good relationship with a health provider (n = 22).Conclusion:This review addresses the gap in knowledge by collating all the patient-reported barriers and facilitators to ART adherence in SSA. Current barriers measures need to be adapted or new tools developed to include the wide variety of factors identified. The factors that have the greatest impact need to be isolated so interventions are developed that reduce the barriers and enhance the facilitators.

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“…Another study showed that 32.9% of the subjects presented forgetfulness as the main cause of non-compliance. (23) A study conducted in South Korea between 2006 and 2015 found that 30% of the participants stopped taking antiretroviral drugs more than once month due to forgetfulness. (24) In addition to the difficulties identified, the consequence of irregular compliance stand out, such as the drop in defense cells and the hospitalizations due to the worsening of the health condition.…”

Section: Discussionmentioning

confidence: 99%

Terapia com antirretrovirais: grau de adesão e a percepção dos indivíduos com HIV/Aids

et al. 2018

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Resumo Objetivo Apreender os aspectos relacionados ao grau de adesão de pessoas vivendo com HIV/aids aos antirretrovirais. Métodos Estudo com abordagem qualitativa desenvolvido em duas unidades de internação de um hospital universitário do interior paulista. A produção dos dados ocorreu no período de outubro de 2017 a abril de 2018 com 40 participantes entrevistados, cujo material produzido foi gravado e posteriormente transcrito. A análise e o processamento dos dados foram realizados com apoio na técnica da Classificação Hierárquica Descendente e base fundamentada no Discurso do Sujeito Coletivo. Resultados Após análise e processamento, obtiveram-se cinco classes de palavras: 1. Questões sócio-econômicas como motivos fundamentais da não adesão aos antirretrovirais; 2. O apoio familiar para o enfrentamento da condição e estímulo para a adesão ao tratamento; 3. Consequências do grau de adesão aos antirretrovirais; 4. Dificuldades de adesão à terapia antirretroviral relacionadas aos efeitos adversos e apresentação medicamentosa; e 5. Possíveis mudanças para melhorar a adesão ao tratamento do HIV. Conclusão As principais dificuldades enfrentadas por pessoas vivendo com HIV/aids hospitalizadas e que estão em adesão irregular são questões sócio-econômicas, apoio familiar e efeitos adversos.

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Facteurs associés à la non observance thérapeutique des sujets adultes infectés par le VIH sous antirétroviraux dans un hôpital de référence à Douala

Cited by 15 publications

References 21 publications

Serum protein electrophoresis as an added value for disease control among HIV patients in a hospital setting in Cameroon

Serum protein electrophoresis as an added value for disease control among HIV patients in a hospital setting in Cameroon

Patient-reported barriers and facilitators to antiretroviral adherence in sub-Saharan Africa

Terapia com antirretrovirais: grau de adesão e a percepção dos indivíduos com HIV/Aids

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