Facteurs cliniques et échographiques influençant le succès du misoprostol pour grossesse arrêtée au premier trimestre

Ménager, N.; Loundou, D.-A.; Chau, C.; Cravello, L.; Gamerre, M.; Agostini, Aubert

doi:10.1016/j.gyobfe.2011.07.047

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Not statistical signi cant but as well there seems to be more frequent secondary curettages with only one cycle of Misoprostol administered (exact value two-sided 0.057 at p < 0.05) meaning premature termination of therapy as wished by the patients. Our ndings are in line with the conclusions from an observational 10 year study [22] which found out that there is a signi cant decrease in successful treatment with misoprostol depending on previous cesarean sections (p = 0.002) and parity (p = 0.048) of the women. The history of one or more cesarean sections led to signi cantly more failure in medical treatment (p = 0.001).…”

Section: Page 4/6supporting

confidence: 91%

Medical treatment of miscarriage using Misoprostol - a retrospective study

Meister,

Künnemann,

Fettke

et al. 2024

Preprint

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Purpose The treatment of early miscarriage with medication is effective and low in side effects. Nevertheless, no uniform dosage regimen has yet been established, nor has it been possible to determine whether previous pregnancies and births with their respective modes of delivery play a role in the effectiveness of Misoprostol. This study aimed to find predictive parameters for successful treatment with Misoprostol in early miscarriage. Methods In a retrospective study at the OVG University Women's Hospital, records of patients with early miscarriage and medical treatment using Misoprostol from 2018-2021 were reviewed for this purpose. The need for a curettage subsequent to treatment was scored as a parameter of failure. The data was analyzed using Statistical Package for the Social Science Version 28.0 (SPSS). The significance level was set to 0.050. Results We found that successful therapy with misoprostol was seen in 86% (n=114). 14% (n=20) of the patients had curettage after taking Misoprostol as advised. Out of 156 women, 19% (n=30) reported mild side effects, with nausea as the leading one (12.2% (n=19)). Significance was found comparing the measurement of double endometrial stripe thickness after the second cycle of Misoprostol in women with and without curettage after medical treatment (exact value two-sided 0.012 at p<0.05). Conclusion Our results indicate that treatment of early miscarriage in the first trimester with Misoprostol is effective and has few side effects. The measurement of the endometrial stripe thickness after the second cycle of Misoprostol via transvaginal ultrasound could present a predictive marker during therapy.

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Section: Page 4/6supporting

confidence: 91%

Medical treatment of miscarriage using Misoprostol - a retrospective study

Meister,

Künnemann,

Fettke

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Previous investigations have reported comparable efficacy of early TOP with the mifepristone–misoprostol combination protocol in women with a scarred and those with an unscarred uterus. However, several studies have indicated that women with previous Cesarean delivery have a higher chance of requiring curettage to complete the TOP than do those with no prior uterine incisions. Moreover, cases of uterine perforation following surgical intervention after failed early TOP have been reported in women with prior Cesarean section.…”

Section: Discussionmentioning

confidence: 99%

“…However, no uterine ruptures occurred in a case series of 392 women with previous Cesarean section undergoing TOP with mifepristone and oral misoprostol, methotrexate and vaginal misoprostol or vaginal misoprostol alone. In contrast, several studies have demonstrated that previous Cesarean delivery might increase the risk of retained products of conception after early TOP. Whether the passage of uterine contents is hampered by CSD during early TOP remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Association between ultrasonographic parameters of Cesarean scar defect and outcome of early termination of pregnancy

Liu

Tzeng

et al. 2016

Ultrasound in Obstet & Gyne

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Medical treatment of miscarriage using misoprostol—a retrospective study

Meister,

Künnemann,

Fettke

et al. 2024

Arch Gynecol Obstet

View full text Add to dashboard Cite

Purpose The treatment of early miscarriage with medication is effective and low in side effects. Nevertheless, no uniform dosage regimen has yet been established, nor has it been possible to determine whether previous pregnancies and births with their respective modes of delivery play a role in the effectiveness of Misoprostol. This study aimed to find predictive parameters for successful treatment with Misoprostol in early miscarriage. Methods In a retrospective study at the Otto von Guericke University Women’s Hospital, records of patients with early miscarriage and medical treatment using Misoprostol from 2018 to 2021 were reviewed for this purpose. The need for a curettage subsequent to treatment was scored as a parameter of failure. The data were analyzed using Statistical Package for the Social Science Version 28.0. The significance level was set to 0.050. Results We found that successful therapy with misoprostol was seen in 86% (n = 114). 14% (n = 20) of the patients had curettage after taking Misoprostol as advised. Out of 134 women, 16% (n = 21) reported mild side effects, with nausea as the leading one (9.2% (n = 12)). Significance was found comparing the measurement of double endometrial stripe thickness after the second cycle of Misoprostol in women with and without curettage after medical treatment (exact value two-sided 0.035 at p < 0.05). A cutoff value at 8.8 mm was calculated using ROC Analysis. Conclusions Our results indicate that the treatment of early miscarriage in the first trimester with Misoprostol is effective and has few side effects. The measurement of the endometrial stripe thickness after the second cycle of Misoprostol via transvaginal ultrasound could present a predictive marker during therapy.

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Facteurs cliniques et échographiques influençant le succès du misoprostol pour grossesse arrêtée au premier trimestre

Cited by 4 publications

References 17 publications

Medical treatment of miscarriage using Misoprostol - a retrospective study

Medical treatment of miscarriage using Misoprostol - a retrospective study

Association between ultrasonographic parameters of Cesarean scar defect and outcome of early termination of pregnancy

Medical treatment of miscarriage using misoprostol—a retrospective study

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